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Phase I first-in-human dose escalation study of the oral casein kinase 1α and cyclin dependent kinase 7/9 inhibitor BTX A51 in advanced MDS and AML.

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Title: Phase I first-in-human dose escalation study of the oral casein kinase 1α and cyclin dependent kinase 7/9 inhibitor BTX A51 in advanced MDS and AML.
Authors: Ball BJ; Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA, USA. brball@coh.org., Xiao W; Memorial Sloan Kettering Cancer Center, New York, NY, USA., Borthakur G; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Nguyen LXT; Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA, USA., Valerio M; Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA, USA., Venkatachalam A; The Lautenberg Center for Immunology and Cancer Research, Institute of Medical Research Israel-Canada, Hebrew University-Hadassah Medical School, Jerusalem, Israel., Marcucci G; Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA, USA., Stein AS; Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA, USA., Thai DL; Edgewood Oncology, Brookline, MA, USA., Cook DN; Edgewood Oncology, Brookline, MA, USA., Chan K; BioTheryx, San Diego, CA, USA., Persaud S; Memorial Sloan Kettering Cancer Center, New York, NY, USA., Levine RL; Memorial Sloan Kettering Cancer Center, New York, NY, USA., Abdel-Wahab O; Memorial Sloan Kettering Cancer Center, New York, NY, USA., Ben-Neriah Y; The Lautenberg Center for Immunology and Cancer Research, Institute of Medical Research Israel-Canada, Hebrew University-Hadassah Medical School, Jerusalem, Israel., Stein EM; Memorial Sloan Kettering Cancer Center, New York, NY, USA. steine@mskcc.org.
Source: Journal of hematology & oncology [J Hematol Oncol] 2025 Jul 15; Vol. 18 (1), pp. 73. Date of Electronic Publication: 2025 Jul 15.
Publication Type: Journal Article; Clinical Trial, Phase I; Research Support, N.I.H., Extramural
Journal Info: Publisher: Biomed Central Country of Publication: England NLM ID: 101468937 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-8722 (Electronic) Linking ISSN: 17568722 NLM ISO Abbreviation: J Hematol Oncol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Phase I first-in-human dose escalation study of the oral casein kinase 1α and cyclin dependent kinase 7/9 inhibitor BTX A51 in advanced MDS and AML.
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  Data: <searchLink fieldCode="AU" term="%22Ball+BJ%22">Ball BJ</searchLink>; Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA, USA. brball@coh.org.<br /><searchLink fieldCode="AU" term="%22Xiao+W%22">Xiao W</searchLink>; Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Borthakur+G%22">Borthakur G</searchLink>; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Nguyen+LXT%22">Nguyen LXT</searchLink>; Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA, USA.<br /><searchLink fieldCode="AU" term="%22Valerio+M%22">Valerio M</searchLink>; Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA, USA.<br /><searchLink fieldCode="AU" term="%22Venkatachalam+A%22">Venkatachalam A</searchLink>; The Lautenberg Center for Immunology and Cancer Research, Institute of Medical Research Israel-Canada, Hebrew University-Hadassah Medical School, Jerusalem, Israel.<br /><searchLink fieldCode="AU" term="%22Marcucci+G%22">Marcucci G</searchLink>; Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA, USA.<br /><searchLink fieldCode="AU" term="%22Stein+AS%22">Stein AS</searchLink>; Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA, USA.<br /><searchLink fieldCode="AU" term="%22Thai+DL%22">Thai DL</searchLink>; Edgewood Oncology, Brookline, MA, USA.<br /><searchLink fieldCode="AU" term="%22Cook+DN%22">Cook DN</searchLink>; Edgewood Oncology, Brookline, MA, USA.<br /><searchLink fieldCode="AU" term="%22Chan+K%22">Chan K</searchLink>; BioTheryx, San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22Persaud+S%22">Persaud S</searchLink>; Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Levine+RL%22">Levine RL</searchLink>; Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Abdel-Wahab+O%22">Abdel-Wahab O</searchLink>; Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Ben-Neriah+Y%22">Ben-Neriah Y</searchLink>; The Lautenberg Center for Immunology and Cancer Research, Institute of Medical Research Israel-Canada, Hebrew University-Hadassah Medical School, Jerusalem, Israel.<br /><searchLink fieldCode="AU" term="%22Stein+EM%22">Stein EM</searchLink>; Memorial Sloan Kettering Cancer Center, New York, NY, USA. steine@mskcc.org.
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  Data: <searchLink fieldCode="JN" term="%22101468937%22">Journal of hematology & oncology</searchLink> [J Hematol Oncol] 2025 Jul 15; Vol. 18 (1), pp. 73. <i>Date of Electronic Publication: </i>2025 Jul 15.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Biomed+Central%22">Biomed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101468937 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1756-8722 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2217568722%22">17568722 </searchLink><i>NLM ISO Abbreviation: </i>J Hematol Oncol <i>Subsets: </i>MEDLINE
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              Text: 2025 Jul 15
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