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Riboflavin drives nucleotide biosynthesis and iron-sulfur metabolism to promote acute myeloid leukemia.

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Title: Riboflavin drives nucleotide biosynthesis and iron-sulfur metabolism to promote acute myeloid leukemia.
Authors: Bjelosevic S; Department of Pediatric Oncology, Dana-Farber Cancer Institute; Division of Hematology/Oncology, Boston Children's Hospital; Harvard Medical School, Boston, MA, 02215 USA.; Broad Institute of MIT and Harvard, Cambridge, MA, 02142 USA., Fauth R; Department of Pediatric Oncology, Dana-Farber Cancer Institute; Division of Hematology/Oncology, Boston Children's Hospital; Harvard Medical School, Boston, MA, 02215 USA.; Broad Institute of MIT and Harvard, Cambridge, MA, 02142 USA., Do BT; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02142 USA.; Harvard-MIT Health Sciences and Technology, Cambridge, MA, 02142 USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02142 USA., Alexe G; Department of Pediatric Oncology, Dana-Farber Cancer Institute; Division of Hematology/Oncology, Boston Children's Hospital; Harvard Medical School, Boston, MA, 02215 USA.; Broad Institute of MIT and Harvard, Cambridge, MA, 02142 USA., Merickel LA; Department of Pediatric Oncology, Dana-Farber Cancer Institute; Division of Hematology/Oncology, Boston Children's Hospital; Harvard Medical School, Boston, MA, 02215 USA.; Broad Institute of MIT and Harvard, Cambridge, MA, 02142 USA., Jackson TD; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, 02215 USA.; Department of Cell Biology, Harvard Medical School, Boston, MA, 02215 USA., Basanthakumar AT; Department of Pediatric Oncology, Dana-Farber Cancer Institute; Division of Hematology/Oncology, Boston Children's Hospital; Harvard Medical School, Boston, MA, 02215 USA.; Broad Institute of MIT and Harvard, Cambridge, MA, 02142 USA., Taillon A; Department of Pediatric Oncology, Dana-Farber Cancer Institute; Division of Hematology/Oncology, Boston Children's Hospital; Harvard Medical School, Boston, MA, 02215 USA.; Broad Institute of MIT and Harvard, Cambridge, MA, 02142 USA., Salhotra S; Department of Pediatric Oncology, Dana-Farber Cancer Institute; Division of Hematology/Oncology, Boston Children's Hospital; Harvard Medical School, Boston, MA, 02215 USA.; Broad Institute of MIT and Harvard, Cambridge, MA, 02142 USA., Ryback B; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, 02215 USA., Schneider C; Department of Pediatric Oncology, Dana-Farber Cancer Institute; Division of Hematology/Oncology, Boston Children's Hospital; Harvard Medical School, Boston, MA, 02215 USA.; Broad Institute of MIT and Harvard, Cambridge, MA, 02142 USA., DiGiovanni G; Department of Pediatric Oncology, Dana-Farber Cancer Institute; Division of Hematology/Oncology, Boston Children's Hospital; Harvard Medical School, Boston, MA, 02215 USA.; Broad Institute of MIT and Harvard, Cambridge, MA, 02142 USA., Elbashir R; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02142 USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02142 USA., Burger N; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, 02215 USA.; Department of Cell Biology, Harvard Medical School, Boston, MA, 02215 USA., Bin Munim M; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02142 USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02142 USA., Lin S; Department of Pediatric Oncology, Dana-Farber Cancer Institute; Division of Hematology/Oncology, Boston Children's Hospital; Harvard Medical School, Boston, MA, 02215 USA.; Broad Institute of MIT and Harvard, Cambridge, MA, 02142 USA., Puigserver P; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, 02215 USA.; Department of Cell Biology, Harvard Medical School, Boston, MA, 02215 USA., Root DE; Broad Institute of MIT and Harvard, Cambridge, MA, 02142 USA., Vander Heiden MG; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02142 USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02142 USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, 02215 USA., Stegmaier K; Department of Pediatric Oncology, Dana-Farber Cancer Institute; Division of Hematology/Oncology, Boston Children's Hospital; Harvard Medical School, Boston, MA, 02215 USA.; Broad Institute of MIT and Harvard, Cambridge, MA, 02142 USA.; Lead contact.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Jun 29. Date of Electronic Publication: 2025 Jun 29.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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DbLabel: MEDLINE Ultimate
An: 40666848
AccessLevel: 2
PubType: Academic Journal
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  Data: Riboflavin drives nucleotide biosynthesis and iron-sulfur metabolism to promote acute myeloid leukemia.
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  Data: <searchLink fieldCode="AU" term="%22Bjelosevic+S%22">Bjelosevic S</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer Institute; Division of Hematology/Oncology, Boston Children's Hospital; Harvard Medical School, Boston, MA, 02215 USA.; Broad Institute of MIT and Harvard, Cambridge, MA, 02142 USA.<br /><searchLink fieldCode="AU" term="%22Fauth+R%22">Fauth R</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer Institute; Division of Hematology/Oncology, Boston Children's Hospital; Harvard Medical School, Boston, MA, 02215 USA.; Broad Institute of MIT and Harvard, Cambridge, MA, 02142 USA.<br /><searchLink fieldCode="AU" term="%22Do+BT%22">Do BT</searchLink>; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02142 USA.; Harvard-MIT Health Sciences and Technology, Cambridge, MA, 02142 USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02142 USA.<br /><searchLink fieldCode="AU" term="%22Alexe+G%22">Alexe G</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer Institute; Division of Hematology/Oncology, Boston Children's Hospital; Harvard Medical School, Boston, MA, 02215 USA.; Broad Institute of MIT and Harvard, Cambridge, MA, 02142 USA.<br /><searchLink fieldCode="AU" term="%22Merickel+LA%22">Merickel LA</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer Institute; Division of Hematology/Oncology, Boston Children's Hospital; Harvard Medical School, Boston, MA, 02215 USA.; Broad Institute of MIT and Harvard, Cambridge, MA, 02142 USA.<br /><searchLink fieldCode="AU" term="%22Jackson+TD%22">Jackson TD</searchLink>; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, 02215 USA.; Department of Cell Biology, Harvard Medical School, Boston, MA, 02215 USA.<br /><searchLink fieldCode="AU" term="%22Basanthakumar+AT%22">Basanthakumar AT</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer Institute; Division of Hematology/Oncology, Boston Children's Hospital; Harvard Medical School, Boston, MA, 02215 USA.; Broad Institute of MIT and Harvard, Cambridge, MA, 02142 USA.<br /><searchLink fieldCode="AU" term="%22Taillon+A%22">Taillon A</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer Institute; Division of Hematology/Oncology, Boston Children's Hospital; Harvard Medical School, Boston, MA, 02215 USA.; Broad Institute of MIT and Harvard, Cambridge, MA, 02142 USA.<br /><searchLink fieldCode="AU" term="%22Salhotra+S%22">Salhotra S</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer Institute; Division of Hematology/Oncology, Boston Children's Hospital; Harvard Medical School, Boston, MA, 02215 USA.; Broad Institute of MIT and Harvard, Cambridge, MA, 02142 USA.<br /><searchLink fieldCode="AU" term="%22Ryback+B%22">Ryback B</searchLink>; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, 02215 USA.<br /><searchLink fieldCode="AU" term="%22Schneider+C%22">Schneider C</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer Institute; Division of Hematology/Oncology, Boston Children's Hospital; Harvard Medical School, Boston, MA, 02215 USA.; Broad Institute of MIT and Harvard, Cambridge, MA, 02142 USA.<br /><searchLink fieldCode="AU" term="%22DiGiovanni+G%22">DiGiovanni G</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer Institute; Division of Hematology/Oncology, Boston Children's Hospital; Harvard Medical School, Boston, MA, 02215 USA.; Broad Institute of MIT and Harvard, Cambridge, MA, 02142 USA.<br /><searchLink fieldCode="AU" term="%22Elbashir+R%22">Elbashir R</searchLink>; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02142 USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02142 USA.<br /><searchLink fieldCode="AU" term="%22Burger+N%22">Burger N</searchLink>; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, 02215 USA.; Department of Cell Biology, Harvard Medical School, Boston, MA, 02215 USA.<br /><searchLink fieldCode="AU" term="%22Bin+Munim+M%22">Bin Munim M</searchLink>; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02142 USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02142 USA.<br /><searchLink fieldCode="AU" term="%22Lin+S%22">Lin S</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer Institute; Division of Hematology/Oncology, Boston Children's Hospital; Harvard Medical School, Boston, MA, 02215 USA.; Broad Institute of MIT and Harvard, Cambridge, MA, 02142 USA.<br /><searchLink fieldCode="AU" term="%22Puigserver+P%22">Puigserver P</searchLink>; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, 02215 USA.; Department of Cell Biology, Harvard Medical School, Boston, MA, 02215 USA.<br /><searchLink fieldCode="AU" term="%22Root+DE%22">Root DE</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, 02142 USA.<br /><searchLink fieldCode="AU" term="%22Vander+Heiden+MG%22">Vander Heiden MG</searchLink>; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02142 USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02142 USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, 02215 USA.<br /><searchLink fieldCode="AU" term="%22Stegmaier+K%22">Stegmaier K</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer Institute; Division of Hematology/Oncology, Boston Children's Hospital; Harvard Medical School, Boston, MA, 02215 USA.; Broad Institute of MIT and Harvard, Cambridge, MA, 02142 USA.; Lead contact.
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