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TDP-43 pathology induces CD8+ T cell activation through cryptic epitope recognition.

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Title: TDP-43 pathology induces CD8+ T cell activation through cryptic epitope recognition.
Authors: Chizari S; Department of Bioengineering, University of Pennsylvania, Philadelphia, USA., Zanovello M; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, UK., Kong S; Department of Bioengineering, University of Pennsylvania, Philadelphia, USA., Saigal V; Department of Bioengineering, University of Pennsylvania, Philadelphia, USA., Brown AL; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, UK., Turchetti V; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, UK., Zampedri L; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, UK., Skorupinska I; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, UK., Minicuci GM; Padua Neuroscience Centre, University of Padua, Italy., Paron F; International Centre for Genetic Engineering and Biotechnology., Tonin P; Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Italy., Marchetto G; Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Italy., Li Z; Center for Alzheimer's and Related Dementias, NIH., Colón-Mercado JM; National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, USA., Dattilo D; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, UK., Barattucci S; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, UK., Gatt A; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, UK., Qi A; Center for Alzheimer's and Related Dementias, NIH., Hanna M; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, UK., Ward M; Center for Alzheimer's and Related Dementias, NIH.; National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, USA., Petrucelli L; Mayo Clinic College of Medicine and Science, Mayo Clinic, USA., Romano M; Department of Life Sciences, University of Trieste, Italy., Vattemi G; Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Italy., Buratti E; International Centre for Genetic Engineering and Biotechnology., Malapsina A; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, UK., Merve A; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, UK., Machado PM; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, UK.; NIHR University College London Hospitals Biomedical Research Centre., Soraru G; Padua Neuroscience Centre, University of Padua, Italy., Fratta P; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, UK.; The Francis Crick Institute, London, UK., Jiang N; Department of Bioengineering, University of Pennsylvania, Philadelphia, USA.; Penn Institute for Immunology and Immune Health, University of Pennsylvania, Philadelphia.; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia.; Abramson Cancer Center, University of Pennsylvania, Philadelphia.; Institute for RNA Innovation, University of Pennsylvania, Philadelphia.; Penn Center for Precision Engineering for Health, University of Pennsylvania, Philadelphia, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Jul 14. Date of Electronic Publication: 2025 Jul 14.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: TDP-43 pathology induces CD8<superscript>+</superscript> T cell activation through cryptic epitope recognition.
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  Data: <searchLink fieldCode="AU" term="%22Chizari+S%22">Chizari S</searchLink>; Department of Bioengineering, University of Pennsylvania, Philadelphia, USA.<br /><searchLink fieldCode="AU" term="%22Zanovello+M%22">Zanovello M</searchLink>; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, UK.<br /><searchLink fieldCode="AU" term="%22Kong+S%22">Kong S</searchLink>; Department of Bioengineering, University of Pennsylvania, Philadelphia, USA.<br /><searchLink fieldCode="AU" term="%22Saigal+V%22">Saigal V</searchLink>; Department of Bioengineering, University of Pennsylvania, Philadelphia, USA.<br /><searchLink fieldCode="AU" term="%22Brown+AL%22">Brown AL</searchLink>; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, UK.<br /><searchLink fieldCode="AU" term="%22Turchetti+V%22">Turchetti V</searchLink>; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, UK.<br /><searchLink fieldCode="AU" term="%22Zampedri+L%22">Zampedri L</searchLink>; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, UK.<br /><searchLink fieldCode="AU" term="%22Skorupinska+I%22">Skorupinska I</searchLink>; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, UK.<br /><searchLink fieldCode="AU" term="%22Minicuci+GM%22">Minicuci GM</searchLink>; Padua Neuroscience Centre, University of Padua, Italy.<br /><searchLink fieldCode="AU" term="%22Paron+F%22">Paron F</searchLink>; International Centre for Genetic Engineering and Biotechnology.<br /><searchLink fieldCode="AU" term="%22Tonin+P%22">Tonin P</searchLink>; Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Italy.<br /><searchLink fieldCode="AU" term="%22Marchetto+G%22">Marchetto G</searchLink>; Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Italy.<br /><searchLink fieldCode="AU" term="%22Li+Z%22">Li Z</searchLink>; Center for Alzheimer's and Related Dementias, NIH.<br /><searchLink fieldCode="AU" term="%22Colón-Mercado+JM%22">Colón-Mercado JM</searchLink>; National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Dattilo+D%22">Dattilo D</searchLink>; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, UK.<br /><searchLink fieldCode="AU" term="%22Barattucci+S%22">Barattucci S</searchLink>; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, UK.<br /><searchLink fieldCode="AU" term="%22Gatt+A%22">Gatt A</searchLink>; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, UK.<br /><searchLink fieldCode="AU" term="%22Qi+A%22">Qi A</searchLink>; Center for Alzheimer's and Related Dementias, NIH.<br /><searchLink fieldCode="AU" term="%22Hanna+M%22">Hanna M</searchLink>; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, UK.<br /><searchLink fieldCode="AU" term="%22Ward+M%22">Ward M</searchLink>; Center for Alzheimer's and Related Dementias, NIH.; National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Petrucelli+L%22">Petrucelli L</searchLink>; Mayo Clinic College of Medicine and Science, Mayo Clinic, USA.<br /><searchLink fieldCode="AU" term="%22Romano+M%22">Romano M</searchLink>; Department of Life Sciences, University of Trieste, Italy.<br /><searchLink fieldCode="AU" term="%22Vattemi+G%22">Vattemi G</searchLink>; Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Italy.<br /><searchLink fieldCode="AU" term="%22Buratti+E%22">Buratti E</searchLink>; International Centre for Genetic Engineering and Biotechnology.<br /><searchLink fieldCode="AU" term="%22Malapsina+A%22">Malapsina A</searchLink>; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, UK.<br /><searchLink fieldCode="AU" term="%22Merve+A%22">Merve A</searchLink>; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, UK.<br /><searchLink fieldCode="AU" term="%22Machado+PM%22">Machado PM</searchLink>; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, UK.; NIHR University College London Hospitals Biomedical Research Centre.<br /><searchLink fieldCode="AU" term="%22Soraru+G%22">Soraru G</searchLink>; Padua Neuroscience Centre, University of Padua, Italy.<br /><searchLink fieldCode="AU" term="%22Fratta+P%22">Fratta P</searchLink>; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, UK.; The Francis Crick Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Jiang+N%22">Jiang N</searchLink>; Department of Bioengineering, University of Pennsylvania, Philadelphia, USA.; Penn Institute for Immunology and Immune Health, University of Pennsylvania, Philadelphia.; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia.; Abramson Cancer Center, University of Pennsylvania, Philadelphia.; Institute for RNA Innovation, University of Pennsylvania, Philadelphia.; Penn Center for Precision Engineering for Health, University of Pennsylvania, Philadelphia, USA.
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