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Combining Machine Learning and Multiplexed, In Situ Profiling to Engineer Cell Type and Behavioral Specificity.

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Title: Combining Machine Learning and Multiplexed, In Situ Profiling to Engineer Cell Type and Behavioral Specificity.
Authors: Leone MJ; Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, United States.; Medical Scientist Training Program, University of Pittsburgh, Pittsburgh, United States., van de Weerd R; Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, United States.; Neuroscience Institute, Carnegie Mellon University, Pittsburgh, United States., Brown AR; Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, United States.; Neuroscience Institute, Carnegie Mellon University, Pittsburgh, United States., Noh MC; Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, United States.; Pittsburgh Center for Pain Research, University of Pittsburgh School of Medicine, Pittsburgh, United States., Phan BN; Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, United States.; Medical Scientist Training Program, University of Pittsburgh, Pittsburgh, United States.; Neuroscience Institute, Carnegie Mellon University, Pittsburgh, United States., Wang AZ; Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, United States., Corrigan KA; Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, United States.; Pittsburgh Center for Pain Research, University of Pittsburgh School of Medicine, Pittsburgh, United States., Yeramosu D; Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, United States., Sestili HH; Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, United States.; Neuroscience Institute, Carnegie Mellon University, Pittsburgh, United States., Arokiaraj CM; Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, United States.; Pittsburgh Center for Pain Research, University of Pittsburgh School of Medicine, Pittsburgh, United States., Lopes BC; Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, United States.; Pittsburgh Center for Pain Research, University of Pittsburgh School of Medicine, Pittsburgh, United States., Cherupally VK; Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, United States.; Neuroscience Institute, Carnegie Mellon University, Pittsburgh, United States., Fields D; Department of Neurosurgery, University of Pittsburgh School of Medicine, Pittsburgh, United States., Babu S; Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, United States., Srinivasan C; Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, United States.; Neuroscience Institute, Carnegie Mellon University, Pittsburgh, United States., Podder R; Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, United States., Gadey L; Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, United States.; Neuroscience Institute, Carnegie Mellon University, Pittsburgh, United States., Headrick D; Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, United States.; Pittsburgh Center for Pain Research, University of Pittsburgh School of Medicine, Pittsburgh, United States., Chen Z; Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, United States.; Neuroscience Institute, Carnegie Mellon University, Pittsburgh, United States.; Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, United States., Franusich ME; Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, United States., Dum R; Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, United States., Lewis DA; Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, United States., Mathys H; Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, United States., Stauffer WR; Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, United States., Seal RP; Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, United States.; Pittsburgh Center for Pain Research, University of Pittsburgh School of Medicine, Pittsburgh, United States.; Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, United States., Pfenning AR; Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, United States.; Neuroscience Institute, Carnegie Mellon University, Pittsburgh, United States.; Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, United States.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Jun 21. Date of Electronic Publication: 2025 Jun 21.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
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Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, United States.; Neuroscience Institute, Carnegie Mellon University, Pittsburgh, United States.<br /><searchLink fieldCode="AU" term="%22Fields+D%22">Fields D</searchLink>; Department of Neurosurgery, University of Pittsburgh School of Medicine, Pittsburgh, United States.<br /><searchLink fieldCode="AU" term="%22Babu+S%22">Babu S</searchLink>; Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, United States.<br /><searchLink fieldCode="AU" term="%22Srinivasan+C%22">Srinivasan C</searchLink>; Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, United States.; Neuroscience Institute, Carnegie Mellon University, Pittsburgh, United States.<br /><searchLink fieldCode="AU" term="%22Podder+R%22">Podder R</searchLink>; Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, United States.<br /><searchLink fieldCode="AU" term="%22Gadey+L%22">Gadey L</searchLink>; Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, United States.; Neuroscience Institute, Carnegie Mellon University, Pittsburgh, United States.<br /><searchLink fieldCode="AU" term="%22Headrick+D%22">Headrick D</searchLink>; Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, United States.; Pittsburgh Center for Pain Research, University of Pittsburgh School of Medicine, Pittsburgh, United States.<br /><searchLink fieldCode="AU" term="%22Chen+Z%22">Chen Z</searchLink>; Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, United States.; Neuroscience Institute, Carnegie Mellon University, Pittsburgh, United States.; Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, United States.<br /><searchLink fieldCode="AU" term="%22Franusich+ME%22">Franusich ME</searchLink>; Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, United States.<br /><searchLink fieldCode="AU" term="%22Dum+R%22">Dum R</searchLink>; 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Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, United States.; Neuroscience Institute, Carnegie Mellon University, Pittsburgh, United States.; Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, United States.
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