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Interpretable deep learning framework for understanding molecular changes in human brains with Alzheimer's disease: implications for microglia activation and sex differences.

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Title: Interpretable deep learning framework for understanding molecular changes in human brains with Alzheimer's disease: implications for microglia activation and sex differences.
Authors: Trivedi MR; School of Computing and Augmented Intelligence, Arizona State University, Tempe, AZ, USA.; ASU-Mayo Center for Innovative Imaging, Tempe, AZ, USA., Joshi AM; School of Computing and Augmented Intelligence, Arizona State University, Tempe, AZ, USA.; ASU-Mayo Center for Innovative Imaging, Tempe, AZ, USA., Shah J; School of Computing and Augmented Intelligence, Arizona State University, Tempe, AZ, USA.; ASU-Mayo Center for Innovative Imaging, Tempe, AZ, USA., Readhead BP; ASU-Banner Neurodegenerative Disease Research Center, Arizona State University, Tempe, AZ, USA., Wilson MA; School of Life Sciences, Arizona State University, Tempe, AZ, USA.; Center for Evolution and Medicine, Arizona State University, Tempe, USA.; The Biodesign Center for Mechanisms of Evolution, Arizona State University, Tempe, AZ, USA., Su Y; ASU-Mayo Center for Innovative Imaging, Tempe, AZ, USA.; Banner Alzheimer's Institute, Phoenix, AZ, USA., Reiman EM; Banner Alzheimer's Institute, Phoenix, AZ, USA., Wu T; School of Computing and Augmented Intelligence, Arizona State University, Tempe, AZ, USA.; ASU-Mayo Center for Innovative Imaging, Tempe, AZ, USA., Wang Q; ASU-Banner Neurodegenerative Disease Research Center, Arizona State University, Tempe, AZ, USA. Qi.Wang.10@asu.edu.
Source: Npj aging [NPJ Aging] 2025 Jul 16; Vol. 11 (1), pp. 66. Date of Electronic Publication: 2025 Jul 16.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: England NLM ID: 9918402285106676 Publication Model: Electronic Cited Medium: Internet ISSN: 2731-6068 (Electronic) Linking ISSN: 27316068 NLM ISO Abbreviation: NPJ Aging Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Interpretable deep learning framework for understanding molecular changes in human brains with Alzheimer's disease: implications for microglia activation and sex differences.
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  Data: <searchLink fieldCode="AU" term="%22Trivedi+MR%22">Trivedi MR</searchLink>; School of Computing and Augmented Intelligence, Arizona State University, Tempe, AZ, USA.; ASU-Mayo Center for Innovative Imaging, Tempe, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Joshi+AM%22">Joshi AM</searchLink>; School of Computing and Augmented Intelligence, Arizona State University, Tempe, AZ, USA.; ASU-Mayo Center for Innovative Imaging, Tempe, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Shah+J%22">Shah J</searchLink>; School of Computing and Augmented Intelligence, Arizona State University, Tempe, AZ, USA.; ASU-Mayo Center for Innovative Imaging, Tempe, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Readhead+BP%22">Readhead BP</searchLink>; ASU-Banner Neurodegenerative Disease Research Center, Arizona State University, Tempe, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Wilson+MA%22">Wilson MA</searchLink>; School of Life Sciences, Arizona State University, Tempe, AZ, USA.; Center for Evolution and Medicine, Arizona State University, Tempe, USA.; The Biodesign Center for Mechanisms of Evolution, Arizona State University, Tempe, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Su+Y%22">Su Y</searchLink>; ASU-Mayo Center for Innovative Imaging, Tempe, AZ, USA.; Banner Alzheimer's Institute, Phoenix, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Reiman+EM%22">Reiman EM</searchLink>; Banner Alzheimer's Institute, Phoenix, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Wu+T%22">Wu T</searchLink>; School of Computing and Augmented Intelligence, Arizona State University, Tempe, AZ, USA.; ASU-Mayo Center for Innovative Imaging, Tempe, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Wang+Q%22">Wang Q</searchLink>; ASU-Banner Neurodegenerative Disease Research Center, Arizona State University, Tempe, AZ, USA. Qi.Wang.10@asu.edu.
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  Data: <searchLink fieldCode="JN" term="%229918402285106676%22">Npj aging</searchLink> [NPJ Aging] 2025 Jul 16; Vol. 11 (1), pp. 66. <i>Date of Electronic Publication: </i>2025 Jul 16.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+Nature%22">Springer Nature </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9918402285106676 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2731-6068 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2227316068%22">27316068 </searchLink><i>NLM ISO Abbreviation: </i>NPJ Aging <i>Subsets: </i>PubMed not MEDLINE
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        Value: 10.1038/s41514-025-00258-5
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              Text: 2025 Jul 16
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