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DNA hypomethylation traits define human regulatory T cells in cutaneous tissue and identify their blood recirculating counterparts.

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Title: DNA hypomethylation traits define human regulatory T cells in cutaneous tissue and identify their blood recirculating counterparts.
Authors: Beumer N; Institute of Immunology, University Medical Center Mainz, Mainz, Germany.; Research Center for Immunotherapy, University Medical Center Mainz, Mainz, Germany.; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany., Imbusch CD; Institute of Immunology, University Medical Center Mainz, Mainz, Germany.; Research Center for Immunotherapy, University Medical Center Mainz, Mainz, Germany.; Division of Applied Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany., Kaufmann T; Institute of Immunology, University Medical Center Mainz, Mainz, Germany.; Research Center for Immunotherapy, University Medical Center Mainz, Mainz, Germany., Schmidleithner L; Leibniz Institute for Immunotherapy, Regensburg, Germany.; Chair for Immunology, University Regensburg, Regensburg, Germany., Gütter K; Leibniz Institute for Immunotherapy, Regensburg, Germany.; Chair for Immunology, University Regensburg, Regensburg, Germany., Stüve P; Leibniz Institute for Immunotherapy, Regensburg, Germany.; Chair for Immunology, University Regensburg, Regensburg, Germany., Marchel H; Leibniz Institute for Immunotherapy, Regensburg, Germany.; Chair for Immunology, University Regensburg, Regensburg, Germany., Weichenhan D; Division of Cancer Epigenomics, German Cancer Research Center (DKFZ), Heidelberg, Germany., Bähr M; Division of Cancer Epigenomics, German Cancer Research Center (DKFZ), Heidelberg, Germany., Ruhland B; Leibniz Institute for Immunotherapy, Regensburg, Germany.; Chair for Immunology, University Regensburg, Regensburg, Germany., Marini F; Research Center for Immunotherapy, University Medical Center Mainz, Mainz, Germany.; Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center Mainz, Mainz, Germany., Sanderink L; Leibniz Institute for Immunotherapy, Regensburg, Germany.; Chair for Immunology, University Regensburg, Regensburg, Germany., Ritter U; Leibniz Institute for Immunotherapy, Regensburg, Germany.; Chair for Immunology, University Regensburg, Regensburg, Germany., Simon M; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany.; Division of Applied Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Leibniz Institute for Immunotherapy, Regensburg, Germany.; Evotec SE, Hamburg, Germany., Braband KL; Institute of Immunology, University Medical Center Mainz, Mainz, Germany.; Research Center for Immunotherapy, University Medical Center Mainz, Mainz, Germany., Voss MM; Institute of Immunology, University Medical Center Mainz, Mainz, Germany.; Research Center for Immunotherapy, University Medical Center Mainz, Mainz, Germany., Helbich SS; Institute of Immunology, University Medical Center Mainz, Mainz, Germany.; Research Center for Immunotherapy, University Medical Center Mainz, Mainz, Germany., Mihoc DM; Institute of Immunology, University Medical Center Mainz, Mainz, Germany.; Research Center for Immunotherapy, University Medical Center Mainz, Mainz, Germany., Hotz-Wagenblatt A; Core Facility Omics IT and Data Management (ODCF), German Cancer Research Center (DKFZ), Heidelberg, Germany., Nassabi H; Department of Dermatology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany., Eigenberger A; Department of Plastic, Hand and Reconstructive Surgery, University Hospital Regensburg, Regensburg, Germany., Prantl L; Department of Plastic, Hand and Reconstructive Surgery, University Hospital Regensburg, Regensburg, Germany., Gebhard C; Leibniz Institute for Immunotherapy, Regensburg, Germany., Rehli M; Leibniz Institute for Immunotherapy, Regensburg, Germany.; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany., Strieder N; Leibniz Institute for Immunotherapy, Regensburg, Germany., Singh K; Institute of Computational Biology, Helmholtz Munich, Munich, Germany., Schmidl C; Leibniz Institute for Immunotherapy, Regensburg, Germany., Plass C; Division of Cancer Epigenomics, German Cancer Research Center (DKFZ), Heidelberg, Germany., Huehn J; Department of Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany.; RESIST, Cluster of Excellence 2155, Hannover Medical School, Hannover, Germany., Hehlgans T; Leibniz Institute for Immunotherapy, Regensburg, Germany.; Chair for Immunology, University Regensburg, Regensburg, Germany., Polansky JK; Immuno-Epigenetics, Berlin Institute of Health Center for Regenerative Therapies at Charité Universitätsmedizin Berlin, Berlin, Germany.; Immuno-Epigenetics, German Rheumatism Research Centre, Berlin, Germany., Brors B; Division of Applied Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT), Heidelberg, Germany.; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.; Medical Faculty Heidelberg and Faculty of Biosciences, Heidelberg University, Heidelberg, Germany., Delacher M; Institute of Immunology, University Medical Center Mainz, Mainz, Germany. delacher@uni-mainz.de.; Research Center for Immunotherapy, University Medical Center Mainz, Mainz, Germany. delacher@uni-mainz.de., Feuerer M; Leibniz Institute for Immunotherapy, Regensburg, Germany. markus.feuerer@ukr.de.; Chair for Immunology, University Regensburg, Regensburg, Germany. markus.feuerer@ukr.de.
Source: Nature immunology [Nat Immunol] 2025 Aug; Vol. 26 (8), pp. 1315-1328. Date of Electronic Publication: 2025 Jul 16.
Publication Type: Journal Article
Journal Info: Publisher: Nature America Inc Country of Publication: United States NLM ID: 100941354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1529-2916 (Electronic) Linking ISSN: 15292908 NLM ISO Abbreviation: Nat Immunol Subsets: MEDLINE
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  Data: DNA hypomethylation traits define human regulatory T cells in cutaneous tissue and identify their blood recirculating counterparts.
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Leibniz Institute for Immunotherapy, Regensburg, Germany.; Evotec SE, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Braband+KL%22">Braband KL</searchLink>; Institute of Immunology, University Medical Center Mainz, Mainz, Germany.; Research Center for Immunotherapy, University Medical Center Mainz, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Voss+MM%22">Voss MM</searchLink>; Institute of Immunology, University Medical Center Mainz, Mainz, Germany.; Research Center for Immunotherapy, University Medical Center Mainz, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Helbich+SS%22">Helbich SS</searchLink>; Institute of Immunology, University Medical Center Mainz, Mainz, Germany.; Research Center for Immunotherapy, University Medical Center Mainz, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Mihoc+DM%22">Mihoc DM</searchLink>; Institute of Immunology, University Medical Center Mainz, Mainz, Germany.; Research Center for Immunotherapy, University Medical Center Mainz, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Hotz-Wagenblatt+A%22">Hotz-Wagenblatt A</searchLink>; Core Facility Omics IT and Data Management (ODCF), German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Nassabi+H%22">Nassabi H</searchLink>; Department of Dermatology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Eigenberger+A%22">Eigenberger A</searchLink>; Department of Plastic, Hand and Reconstructive Surgery, University Hospital Regensburg, Regensburg, Germany.<br /><searchLink fieldCode="AU" term="%22Prantl+L%22">Prantl L</searchLink>; Department of Plastic, Hand and Reconstructive Surgery, University Hospital Regensburg, Regensburg, Germany.<br /><searchLink fieldCode="AU" term="%22Gebhard+C%22">Gebhard C</searchLink>; Leibniz Institute for Immunotherapy, Regensburg, Germany.<br /><searchLink fieldCode="AU" term="%22Rehli+M%22">Rehli M</searchLink>; Leibniz Institute for Immunotherapy, Regensburg, Germany.; Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany.<br /><searchLink fieldCode="AU" term="%22Strieder+N%22">Strieder N</searchLink>; Leibniz Institute for Immunotherapy, Regensburg, Germany.<br /><searchLink fieldCode="AU" term="%22Singh+K%22">Singh K</searchLink>; Institute of Computational Biology, Helmholtz Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Schmidl+C%22">Schmidl C</searchLink>; Leibniz Institute for Immunotherapy, Regensburg, Germany.<br /><searchLink fieldCode="AU" term="%22Plass+C%22">Plass C</searchLink>; Division of Cancer Epigenomics, German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Huehn+J%22">Huehn J</searchLink>; Department of Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany.; RESIST, Cluster of Excellence 2155, Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Hehlgans+T%22">Hehlgans T</searchLink>; Leibniz Institute for Immunotherapy, Regensburg, Germany.; Chair for Immunology, University Regensburg, Regensburg, Germany.<br /><searchLink fieldCode="AU" term="%22Polansky+JK%22">Polansky JK</searchLink>; Immuno-Epigenetics, Berlin Institute of Health Center for Regenerative Therapies at Charité Universitätsmedizin Berlin, Berlin, Germany.; Immuno-Epigenetics, German Rheumatism Research Centre, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Brors+B%22">Brors B</searchLink>; Division of Applied Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT), Heidelberg, Germany.; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.; Medical Faculty Heidelberg and Faculty of Biosciences, Heidelberg University, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Delacher+M%22">Delacher M</searchLink>; Institute of Immunology, University Medical Center Mainz, Mainz, Germany. delacher@uni-mainz.de.; Research Center for Immunotherapy, University Medical Center Mainz, Mainz, Germany. delacher@uni-mainz.de.<br /><searchLink fieldCode="AU" term="%22Feuerer+M%22">Feuerer M</searchLink>; Leibniz Institute for Immunotherapy, Regensburg, Germany. markus.feuerer@ukr.de.; Chair for Immunology, University Regensburg, Regensburg, Germany. markus.feuerer@ukr.de.
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