Extracellular vesicle-enriched secretome of adipose-derived stem cells upregulates clusterin to alleviate doxorubicin-induced apoptosis in cardiomyocytes.

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Title: Extracellular vesicle-enriched secretome of adipose-derived stem cells upregulates clusterin to alleviate doxorubicin-induced apoptosis in cardiomyocytes.
Authors: Hsu WT; School of Pharmacy, College of Medicine, National Taiwan University, 33 Linsen S. Rd., R201, Zhongzheng Dist, Taipei, 100025, Taiwan. wantsenghsu@ntu.edu.tw., Kobuchi S; Laboratory of Pharmacokinetics, Kyoto Pharmaceutical University, Kyoto, Japan., Chien TR; Graduate Institute of Clinical Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan., Chen IC; Department of Medical Oncology, National Taiwan University Cancer Center, Taipei, Taiwan.; Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan.; Graduate Institute of Oncology, College of Medicine, National Taiwan University, Taipei, Taiwan., Hamada S; Division of Pharmaceutical Sciences, Kanazawa University, Kanazawa, Japan., Tsujimoto M; Laboratory of Clinical Pharmacy, Kyoto Pharmaceutical University, Kyoto, Japan., Tsai IL; Department of Biochemistry and Molecular Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan., Wong YS; School of Pharmacy, College of Medicine, National Taiwan University, 33 Linsen S. Rd., R201, Zhongzheng Dist, Taipei, 100025, Taiwan., Tung KH; School of Pharmacy, College of Medicine, National Taiwan University, 33 Linsen S. Rd., R201, Zhongzheng Dist, Taipei, 100025, Taiwan., He YZ; School of Pharmacy, College of Medicine, National Taiwan University, 33 Linsen S. Rd., R201, Zhongzheng Dist, Taipei, 100025, Taiwan.
Source: Biology direct [Biol Direct] 2025 Jul 16; Vol. 20 (1), pp. 84. Date of Electronic Publication: 2025 Jul 16.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101258412 Publication Model: Electronic Cited Medium: Internet ISSN: 1745-6150 (Electronic) Linking ISSN: 17456150 NLM ISO Abbreviation: Biol Direct Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1745-6150
DOI:10.1186/s13062-025-00664-5