View in EDS

Cell-resolved high-dimensional imaging analysis, therapeutic modeling, and a Phase Ib clinical study establish BCL-2 as a target across heterogeneous CRPC subtypes.

Saved in:
Bibliographic Details
Title: Cell-resolved high-dimensional imaging analysis, therapeutic modeling, and a Phase Ib clinical study establish BCL-2 as a target across heterogeneous CRPC subtypes.
Authors: Jamroze A; Department of Pharmacology & Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA., Liu X; Department of Pharmacology & Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA., Hou S; Department of Biostatistics & Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA., Li WJ; Department of Pharmacology & Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA.; Experimental Therapeutics (ET) Graduate Program, Roswell Park Comprehensive Cancer Center and the University at Buffalo, Buffalo, NY 14263, USA., Yu H; Department of Biostatistics & Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA., Tracz A; Department of Pharmacology & Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA., Li Q; Department of Pharmacology & Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA., Nastiuk K; Departments of Cancer Genetics and Urology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA., Chen X; Department of Pharmacology & Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA., Huang J; Department of Pathology, Duke University School of Medicine, Durham, NC 27710 USA., Lin K; Department of Epigenetics and Molecular Carcinogenesis, the University of Texas M.D Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA., Lu Y; Department of Epigenetics and Molecular Carcinogenesis, the University of Texas M.D Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA., Puzanov I; Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA., Kirk JS; Department of Pharmacology & Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA., Chatta G; Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA., Tang DG; Department of Pharmacology & Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA.; Experimental Therapeutics (ET) Graduate Program, Roswell Park Comprehensive Cancer Center and the University at Buffalo, Buffalo, NY 14263, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Jul 23. Date of Electronic Publication: 2025 Jul 23.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 40672185
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Cell-resolved high-dimensional imaging analysis, therapeutic modeling, and a Phase Ib clinical study establish BCL-2 as a target across heterogeneous CRPC subtypes.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Jamroze+A%22">Jamroze A</searchLink>; Department of Pharmacology & Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA.<br /><searchLink fieldCode="AU" term="%22Liu+X%22">Liu X</searchLink>; Department of Pharmacology & Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA.<br /><searchLink fieldCode="AU" term="%22Hou+S%22">Hou S</searchLink>; Department of Biostatistics & Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA.<br /><searchLink fieldCode="AU" term="%22Li+WJ%22">Li WJ</searchLink>; Department of Pharmacology & Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA.; Experimental Therapeutics (ET) Graduate Program, Roswell Park Comprehensive Cancer Center and the University at Buffalo, Buffalo, NY 14263, USA.<br /><searchLink fieldCode="AU" term="%22Yu+H%22">Yu H</searchLink>; Department of Biostatistics & Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA.<br /><searchLink fieldCode="AU" term="%22Tracz+A%22">Tracz A</searchLink>; Department of Pharmacology & Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA.<br /><searchLink fieldCode="AU" term="%22Li+Q%22">Li Q</searchLink>; Department of Pharmacology & Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA.<br /><searchLink fieldCode="AU" term="%22Nastiuk+K%22">Nastiuk K</searchLink>; Departments of Cancer Genetics and Urology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA.<br /><searchLink fieldCode="AU" term="%22Chen+X%22">Chen X</searchLink>; Department of Pharmacology & Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA.<br /><searchLink fieldCode="AU" term="%22Huang+J%22">Huang J</searchLink>; Department of Pathology, Duke University School of Medicine, Durham, NC 27710 USA.<br /><searchLink fieldCode="AU" term="%22Lin+K%22">Lin K</searchLink>; Department of Epigenetics and Molecular Carcinogenesis, the University of Texas M.D Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Lu+Y%22">Lu Y</searchLink>; Department of Epigenetics and Molecular Carcinogenesis, the University of Texas M.D Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Puzanov+I%22">Puzanov I</searchLink>; Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA.<br /><searchLink fieldCode="AU" term="%22Kirk+JS%22">Kirk JS</searchLink>; Department of Pharmacology & Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA.<br /><searchLink fieldCode="AU" term="%22Chatta+G%22">Chatta G</searchLink>; Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA.<br /><searchLink fieldCode="AU" term="%22Tang+DG%22">Tang DG</searchLink>; Department of Pharmacology & Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA.; Experimental Therapeutics (ET) Graduate Program, Roswell Park Comprehensive Cancer Center and the University at Buffalo, Buffalo, NY 14263, USA.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22101680187%22">BioRxiv : the preprint server for biology</searchLink> [bioRxiv] 2025 Jul 23. <i>Date of Electronic Publication: </i>2025 Jul 23.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article; Preprint
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Country of Publication: </i>United States <i>NLM ID: </i>101680187 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2692-8205 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2226928205%22">26928205 </searchLink><i>NLM ISO Abbreviation: </i>bioRxiv <i>Subsets: </i>PubMed not MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=40672185
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1101/2025.07.08.663739
    Languages:
      – Code: eng
        Text: English
    Titles:
      – TitleFull: Cell-resolved high-dimensional imaging analysis, therapeutic modeling, and a Phase Ib clinical study establish BCL-2 as a target across heterogeneous CRPC subtypes.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Jamroze A
      – PersonEntity:
          Name:
            NameFull: Liu X
      – PersonEntity:
          Name:
            NameFull: Hou S
      – PersonEntity:
          Name:
            NameFull: Li WJ
      – PersonEntity:
          Name:
            NameFull: Yu H
      – PersonEntity:
          Name:
            NameFull: Tracz A
      – PersonEntity:
          Name:
            NameFull: Li Q
      – PersonEntity:
          Name:
            NameFull: Nastiuk K
      – PersonEntity:
          Name:
            NameFull: Chen X
      – PersonEntity:
          Name:
            NameFull: Huang J
      – PersonEntity:
          Name:
            NameFull: Lin K
      – PersonEntity:
          Name:
            NameFull: Lu Y
      – PersonEntity:
          Name:
            NameFull: Puzanov I
      – PersonEntity:
          Name:
            NameFull: Kirk JS
      – PersonEntity:
          Name:
            NameFull: Chatta G
      – PersonEntity:
          Name:
            NameFull: Tang DG
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 23
              M: 07
              Text: 2025 Jul 23
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-electronic
              Value: 2692-8205
          Titles:
            – TitleFull: BioRxiv : the preprint server for biology
              Type: main
ResultId 1