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The Global Landscape of Genetic Variation in Parkinson's disease: Multi-Ancestry Insights into Established Disease Genes and their Translational Relevance.

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Title: The Global Landscape of Genetic Variation in Parkinson's disease: Multi-Ancestry Insights into Established Disease Genes and their Translational Relevance.
Authors: Lange LM; Laboratory of Neurogenetics, National Institute on Aging, Bethesda, Maryland, USA.; Institute of Neurogenetics, University of Luebeck, Luebeck, Germany., Fang ZH; German Center for Neurodegenerative Diseases (DZNE), Tu bingen, Germany., Makarious MB; DataTecnica, Washington, DC, USA.; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Kuznetsov N; DataTecnica, Washington, DC, USA.; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Brolin KA; Translational Neurogenetics Unit, Department of Experimental Medical Science, Lund University, Lund, Sweden.; Centre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of London, London, United Kingdom., Ballard S; DataTecnica, Washington, DC, USA.; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Bardien S; Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University; South African Medical Research Council/Stellenbosch University Genomics of Brain Disorders Research Unit, Cape Town, South Africa., Doquenia ML; Department of Neuroscience and Brain Health, Metropolitan Medical Center, Manila, Philippines.; Department of Clinical Neurosciences, Mary Mediatrix Medical Center, Lipa, Batangas, Philippines.; Department of Anatomy, University of the East Ramon Magsaysay Memorial Medical Center, Quezon City, Philippines., Heutink P; The Global Parkinson's Genetics Program (GP2)., Houlden H; University College London, Institute of Neurology, Department of Neuromuscular Diseases, Queen Square, WC1N 3BG London, UK., Iwaki H; DataTecnica, Washington, DC, USA.; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Jasaityte S; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK., Jones L; DataTecnica, Washington, DC, USA.; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Junker J; University Hospital Schleswig Holstein, Campus Luebeck, Luebeck, Germany.; Center for Movement Disorders and Neuromodulation, University Hospital Duesseldorf, Duesseldorf, Germany., Kaiyrzhanov R; University College London, Institute of Neurology, Department of Neuromuscular Diseases, Queen Square, WC1N 3BG London, UK.; Department of Neurology, South Kazakhstan Medical Academy, 160019, Shymkent, Kazakhstan., Koretsky MJ; DataTecnica, Washington, DC, USA.; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Kumar KR; Neurology Department and Molecular Medicine Laboratory, Concord Repatriation General Hospital and University of Sydney, Concord, NSW, 2139.; Translational Neurogenomics Group, Genomics and Inherited Disease Program, The Garvan Institute of Medical Research, Darlinghurst, NSW, 2010, Australia.; Faculty of Medicine and Health, University of New South Wales, Sydney, NSW, Australia., Leonard HL; DataTecnica, Washington, DC, USA.; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Levine KS; DataTecnica, Washington, DC, USA.; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Lim SY; Division of Neurology, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia., Mencacci NE; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Mohamed WMY; Department of Basic Medical Sciences, Kulliyyah of Medicine, International Islamic University Malaysia (IIUM), Kuantan, Pahang, Malaysia.; Clinical Pharmacology Department, Menoufia Medical School, Menoufia University, Shebin El-Kom, Menoufia, Egypt., Nalls MA; DataTecnica, Washington, DC, USA.; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Noyce AJ; Centre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of London, London, United Kingdom., Ojha R; Department of Neurology, Tribhuvan University Teaching Hospital, Kathmandu, Nepal., Okubadejo NU; Neurology Unit, Department of Medicine, College of Medicine, University of Lagos, Lagos State, Nigeria., Rehman SU; Department of Biotechnology, University of science and Technology Bannu, Pakistan., Screven L; The Global Parkinson's Genetics Program (GP2)., Shashkin C; International Research Institute of Postgraduate Education, Department of Neurosurgery and Neurology, Almaty, Kazakhstan.; Shashkin Clinic, Almaty, Kazakhstan., Sopromadze S; Department of Neurology, Ivane Javakhishvili Tbilisi State University, Tbilisi, Georgia.; East European University (EEU), Tbilisi, Georgia., Stafford EJ; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK., Tan AH; Division of Neurology, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia., Tan M; Centre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of London, London, United Kingdom.; Department of Neurology, Oslo University Hospital, Oslo, Norway., Tavadyan Z; National Institute of Health, Yerevan, Armenia., Trinh J; Institute of Neurogenetics, University of Luebeck, Luebeck, Germany., Tserensodnom B; Department of Neurology, School of Medicine, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia., Valente EM; Department of Molecular Medicine, University of Pavia, Pavia, Italy.; Neurogenetics Research Center, IRCCS Mondino Foundation, Pavia, Italy., Vitale D; DataTecnica, Washington, DC, USA.; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Zharkinbekova N; Neurology Department and Molecular Medicine Laboratory, Concord Repatriation General Hospital and University of Sydney, Concord, NSW, 2139., Lohmann K; Institute of Neurogenetics, University of Luebeck, Luebeck, Germany., Bandres-Ciga S; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Blauwendraat C; The Global Parkinson's Genetics Program (GP2)., Singleton A; The Global Parkinson's Genetics Program (GP2)., Morris HR; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.; UCL Movement Disorders Centre, University College London, London, UK., Klein C; Institute of Neurogenetics, University of Luebeck, Luebeck, Germany.
Corporate Authors: Latin American Research Consortium on the Genetics of Parkinson's Disease (LARGE-PD), Global Parkinson’s Genetics Program (GP2)
Source: MedRxiv : the preprint server for health sciences [medRxiv] 2025 Jul 11. Date of Electronic Publication: 2025 Jul 11.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: The Global Landscape of Genetic Variation in Parkinson's disease: Multi-Ancestry Insights into Established Disease Genes and their Translational Relevance.
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  Data: <searchLink fieldCode="AU" term="%22Lange+LM%22">Lange LM</searchLink>; Laboratory of Neurogenetics, National Institute on Aging, Bethesda, Maryland, USA.; Institute of Neurogenetics, University of Luebeck, Luebeck, Germany.<br /><searchLink fieldCode="AU" term="%22Fang+ZH%22">Fang ZH</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Tu bingen, Germany.<br /><searchLink fieldCode="AU" term="%22Makarious+MB%22">Makarious MB</searchLink>; DataTecnica, Washington, DC, USA.; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Kuznetsov+N%22">Kuznetsov N</searchLink>; DataTecnica, Washington, DC, USA.; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Brolin+KA%22">Brolin KA</searchLink>; Translational Neurogenetics Unit, Department of Experimental Medical Science, Lund University, Lund, Sweden.; Centre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Ballard+S%22">Ballard S</searchLink>; DataTecnica, Washington, DC, USA.; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Bardien+S%22">Bardien S</searchLink>; Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University; South African Medical Research Council/Stellenbosch University Genomics of Brain Disorders Research Unit, Cape Town, South Africa.<br /><searchLink fieldCode="AU" term="%22Doquenia+ML%22">Doquenia ML</searchLink>; Department of Neuroscience and Brain Health, Metropolitan Medical Center, Manila, Philippines.; 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DataTecnica, Washington, DC, USA.; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Junker+J%22">Junker J</searchLink>; University Hospital Schleswig Holstein, Campus Luebeck, Luebeck, Germany.; Center for Movement Disorders and Neuromodulation, University Hospital Duesseldorf, Duesseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Kaiyrzhanov+R%22">Kaiyrzhanov R</searchLink>; University College London, Institute of Neurology, Department of Neuromuscular Diseases, Queen Square, WC1N 3BG London, UK.; Department of Neurology, South Kazakhstan Medical Academy, 160019, Shymkent, Kazakhstan.<br /><searchLink fieldCode="AU" term="%22Koretsky+MJ%22">Koretsky MJ</searchLink>; DataTecnica, Washington, DC, USA.; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Kumar+KR%22">Kumar KR</searchLink>; 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