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Design of intrinsically disordered region binding proteins.

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Title: Design of intrinsically disordered region binding proteins.
Authors: Wu K; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.; Biological Physics, Structure and Design Graduate Program, University of Washington, Seattle, WA, USA., Jiang H; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.; Department of Electrical Engineering and Computer Science, University of California, Berkeley, CA, USA., Hicks DR; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Liu C; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Muratspahić E; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Ramelot TA; Department of Chemistry and Chemical Biology, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, USA., Liu Y; Department of Chemistry, University of Washington, Seattle, WA, USA., McNally K; MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK., Kenny S; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Mihut A; MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK., Gaur A; Department of Chemistry and Chemical Biology, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, USA., Coventry B; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA., Chen W; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Bera AK; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Kang A; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Gerben S; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Lamb MY; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Murray A; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Li X; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Kennedy MA; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Yang W; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Song Z; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Schober G; Visceral Pain Research Group, Hopwood Centre for Neurobiology, Lifelong Health Theme, South Australian Health and Medical Research Institute (SAHMRI), North Terrace, Adelaide, South Australia, Australia.; Faculty of Health and Medical Sciences, University of Adelaide, North Terrace, Adelaide, South Australia, Australia., Brierley SM; Visceral Pain Research Group, Hopwood Centre for Neurobiology, Lifelong Health Theme, South Australian Health and Medical Research Institute (SAHMRI), North Terrace, Adelaide, South Australia, Australia.; Faculty of Health and Medical Sciences, University of Adelaide, North Terrace, Adelaide, South Australia, Australia., O'Neill J; MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK., Gelb MH; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Department of Chemistry, University of Washington, Seattle, WA, USA., Montelione GT; Department of Chemistry and Chemical Biology, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, USA., Derivery E; MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK., Baker D; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA.
Source: Science (New York, N.Y.) [Science] 2025 Jul 17; Vol. 389 (6757), pp. eadr8063. Date of Electronic Publication: 2025 Jul 17.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Wu+K%22">Wu K</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.; Biological Physics, Structure and Design Graduate Program, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Jiang+H%22">Jiang H</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.; Department of Electrical Engineering and Computer Science, University of California, Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22Hicks+DR%22">Hicks DR</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Liu+C%22">Liu C</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Muratspahić+E%22">Muratspahić E</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Ramelot+TA%22">Ramelot TA</searchLink>; Department of Chemistry and Chemical Biology, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, USA.<br /><searchLink fieldCode="AU" term="%22Liu+Y%22">Liu Y</searchLink>; Department of Chemistry, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22McNally+K%22">McNally K</searchLink>; MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK.<br /><searchLink fieldCode="AU" term="%22Kenny+S%22">Kenny S</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Mihut+A%22">Mihut A</searchLink>; MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK.<br /><searchLink fieldCode="AU" term="%22Gaur+A%22">Gaur A</searchLink>; Department of Chemistry and Chemical Biology, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, USA.<br /><searchLink fieldCode="AU" term="%22Coventry+B%22">Coventry B</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Chen+W%22">Chen W</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Bera+AK%22">Bera AK</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Kang+A%22">Kang A</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Gerben+S%22">Gerben S</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Lamb+MY%22">Lamb MY</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Murray+A%22">Murray A</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Li+X%22">Li X</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Kennedy+MA%22">Kennedy MA</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Yang+W%22">Yang W</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Song+Z%22">Song Z</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Schober+G%22">Schober G</searchLink>; Visceral Pain Research Group, Hopwood Centre for Neurobiology, Lifelong Health Theme, South Australian Health and Medical Research Institute (SAHMRI), North Terrace, Adelaide, South Australia, Australia.; Faculty of Health and Medical Sciences, University of Adelaide, North Terrace, Adelaide, South Australia, Australia.<br /><searchLink fieldCode="AU" term="%22Brierley+SM%22">Brierley SM</searchLink>; Visceral Pain Research Group, Hopwood Centre for Neurobiology, Lifelong Health Theme, South Australian Health and Medical Research Institute (SAHMRI), North Terrace, Adelaide, South Australia, Australia.; Faculty of Health and Medical Sciences, University of Adelaide, North Terrace, Adelaide, South Australia, Australia.<br /><searchLink fieldCode="AU" term="%22O'Neill+J%22">O'Neill J</searchLink>; MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK.<br /><searchLink fieldCode="AU" term="%22Gelb+MH%22">Gelb MH</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Department of Chemistry, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Montelione+GT%22">Montelione GT</searchLink>; Department of Chemistry and Chemical Biology, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, USA.<br /><searchLink fieldCode="AU" term="%22Derivery+E%22">Derivery E</searchLink>; MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK.<br /><searchLink fieldCode="AU" term="%22Baker+D%22">Baker D</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA.
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