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The diabetes gene Tcf7l2 organizes gene expression in the liver and regulates amino acid metabolism.

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Title: The diabetes gene Tcf7l2 organizes gene expression in the liver and regulates amino acid metabolism.
Authors: Krawczyk J; Division of Endocrinology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., O'Connor W; Division of Endocrinology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Vendramini P; Division of Endocrinology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Schell M; Division of Endocrinology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Biddinger KJ; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA; Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Kanke M; Department of Biomedical Sciences, Cornell University, Ithaca, NY, USA., Pengo G; Division of Endocrinology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Semova I; Division of Endocrinology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Fougeray T; Division of Endocrinology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Haigis M; Department of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA., Aragam KG; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA; Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Lamers WH; Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, University of Amsterdam, Meibergdreef 69-71, 1105 BK, Amsterdam, the Netherlands., Tsai LT; Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA, USA; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Sethupathy P; Department of Biomedical Sciences, Cornell University, Ithaca, NY, USA., Biddinger SB; Division of Endocrinology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA; Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA, USA; Broad Institute of Harvard and MIT, Cambridge, MA, USA; Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, MA, USA. Electronic address: sudha.biddinger@childrens.harvard.edu.
Source: Molecular metabolism [Mol Metab] 2025 Sep; Vol. 99, pp. 102208. Date of Electronic Publication: 2025 Jul 15.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier GmbH Country of Publication: Germany NLM ID: 101605730 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2212-8778 (Electronic) Linking ISSN: 22128778 NLM ISO Abbreviation: Mol Metab Subsets: MEDLINE
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  Data: The diabetes gene Tcf7l2 organizes gene expression in the liver and regulates amino acid metabolism.
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  Data: <searchLink fieldCode="AU" term="%22Krawczyk+J%22">Krawczyk J</searchLink>; Division of Endocrinology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22O'Connor+W%22">O'Connor W</searchLink>; Division of Endocrinology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Vendramini+P%22">Vendramini P</searchLink>; Division of Endocrinology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Schell+M%22">Schell M</searchLink>; Division of Endocrinology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Biddinger+KJ%22">Biddinger KJ</searchLink>; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA; Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Kanke+M%22">Kanke M</searchLink>; Department of Biomedical Sciences, Cornell University, Ithaca, NY, USA.<br /><searchLink fieldCode="AU" term="%22Pengo+G%22">Pengo G</searchLink>; Division of Endocrinology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Semova+I%22">Semova I</searchLink>; Division of Endocrinology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Fougeray+T%22">Fougeray T</searchLink>; Division of Endocrinology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Haigis+M%22">Haigis M</searchLink>; Department of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Aragam+KG%22">Aragam KG</searchLink>; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA; Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Lamers+WH%22">Lamers WH</searchLink>; Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, University of Amsterdam, Meibergdreef 69-71, 1105 BK, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Tsai+LT%22">Tsai LT</searchLink>; Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA, USA; Broad Institute of Harvard and MIT, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Sethupathy+P%22">Sethupathy P</searchLink>; Department of Biomedical Sciences, Cornell University, Ithaca, NY, USA.<br /><searchLink fieldCode="AU" term="%22Biddinger+SB%22">Biddinger SB</searchLink>; Division of Endocrinology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA; Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA, USA; Broad Institute of Harvard and MIT, Cambridge, MA, USA; Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, MA, USA. Electronic address: sudha.biddinger@childrens.harvard.edu.
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  Data: <searchLink fieldCode="JN" term="%22101605730%22">Molecular metabolism</searchLink> [Mol Metab] 2025 Sep; Vol. 99, pp. 102208. <i>Date of Electronic Publication: </i>2025 Jul 15.
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