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BRAFV600E maintains the CpG island methylator phenotype, and DNA methylation of PRC2 targets genes in colon cancer.

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Title: BRAFV600E maintains the CpG island methylator phenotype, and DNA methylation of PRC2 targets genes in colon cancer.
Authors: El Bouazzaoui L; Division of Imaging and Cancer, Laboratory Translational Oncology, UMC Utrecht, Utrecht, the Netherlands.; Oncode Institute and Center for Molecular Medicine, UMC Utrecht, Utrecht, the Netherlands.; Utrecht Platform for Organoid Technology, Utrecht University, Utrecht, the Netherlands., Bugter JM; Oncode Institute and Center for Molecular Medicine, UMC Utrecht, Utrecht, the Netherlands., Küçükköse E; Division of Imaging and Cancer, Laboratory Translational Oncology, UMC Utrecht, Utrecht, the Netherlands., Verheem A; Division of Imaging and Cancer, Laboratory Translational Oncology, UMC Utrecht, Utrecht, the Netherlands., Post JB; Oncode Institute and Center for Molecular Medicine, UMC Utrecht, Utrecht, the Netherlands., Fenderico N; Oncode Institute and Center for Molecular Medicine, UMC Utrecht, Utrecht, the Netherlands., Borel Rinkes IHM; Division of Imaging and Cancer, Laboratory Translational Oncology, UMC Utrecht, Utrecht, the Netherlands., Snippert HJG; Oncode Institute and Center for Molecular Medicine, UMC Utrecht, Utrecht, the Netherlands., Maurice MM; Oncode Institute and Center for Molecular Medicine, UMC Utrecht, Utrecht, the Netherlands.; Utrecht Platform for Organoid Technology, Utrecht University, Utrecht, the Netherlands., Kranenburg O; Division of Imaging and Cancer, Laboratory Translational Oncology, UMC Utrecht, Utrecht, the Netherlands.; Utrecht Platform for Organoid Technology, Utrecht University, Utrecht, the Netherlands.
Source: IScience [iScience] 2025 Jun 14; Vol. 28 (7), pp. 112905. Date of Electronic Publication: 2025 Jun 14 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101724038 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-0042 (Electronic) Linking ISSN: 25890042 NLM ISO Abbreviation: iScience Subsets: PubMed not MEDLINE
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  Data: BRAF<superscript>V600E</superscript> maintains the CpG island methylator phenotype, and DNA methylation of PRC2 targets genes in colon cancer.
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  Data: <searchLink fieldCode="AU" term="%22El+Bouazzaoui+L%22">El Bouazzaoui L</searchLink>; Division of Imaging and Cancer, Laboratory Translational Oncology, UMC Utrecht, Utrecht, the Netherlands.; Oncode Institute and Center for Molecular Medicine, UMC Utrecht, Utrecht, the Netherlands.; Utrecht Platform for Organoid Technology, Utrecht University, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Bugter+JM%22">Bugter JM</searchLink>; Oncode Institute and Center for Molecular Medicine, UMC Utrecht, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Küçükköse+E%22">Küçükköse E</searchLink>; Division of Imaging and Cancer, Laboratory Translational Oncology, UMC Utrecht, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Verheem+A%22">Verheem A</searchLink>; Division of Imaging and Cancer, Laboratory Translational Oncology, UMC Utrecht, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Post+JB%22">Post JB</searchLink>; Oncode Institute and Center for Molecular Medicine, UMC Utrecht, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Fenderico+N%22">Fenderico N</searchLink>; Oncode Institute and Center for Molecular Medicine, UMC Utrecht, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Borel+Rinkes+IHM%22">Borel Rinkes IHM</searchLink>; Division of Imaging and Cancer, Laboratory Translational Oncology, UMC Utrecht, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Snippert+HJG%22">Snippert HJG</searchLink>; Oncode Institute and Center for Molecular Medicine, UMC Utrecht, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Maurice+MM%22">Maurice MM</searchLink>; Oncode Institute and Center for Molecular Medicine, UMC Utrecht, Utrecht, the Netherlands.; Utrecht Platform for Organoid Technology, Utrecht University, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Kranenburg+O%22">Kranenburg O</searchLink>; Division of Imaging and Cancer, Laboratory Translational Oncology, UMC Utrecht, Utrecht, the Netherlands.; Utrecht Platform for Organoid Technology, Utrecht University, Utrecht, the Netherlands.
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  Data: <searchLink fieldCode="JN" term="%22101724038%22">IScience</searchLink> [iScience] 2025 Jun 14; Vol. 28 (7), pp. 112905. <i>Date of Electronic Publication: </i>2025 Jun 14 (<i>Print Publication: </i>2025).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Cell+Press%22">Cell Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101724038 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>2589-0042 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2225890042%22">25890042 </searchLink><i>NLM ISO Abbreviation: </i>iScience <i>Subsets: </i>PubMed not MEDLINE
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              Text: 2025 Jun 14
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