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Iodine-promoted oxidative cross-coupling for the synthesis of (E)-2-(3-oxo-3-phenylprop-1-en-1-yl)-3-phenylquinazolin-4(3H)-one via C-H activation: development of synthetic TLX agonists.

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Title: Iodine-promoted oxidative cross-coupling for the synthesis of (E)-2-(3-oxo-3-phenylprop-1-en-1-yl)-3-phenylquinazolin-4(3H)-one via C-H activation: development of synthetic TLX agonists.
Authors: Maram L; Department of Anesthesiology, Washington University in St Louis, St Louis, MO, USA. belgendy@wustl.edu.; Center for Clinical Pharmacology, Washington University School of Medicine and University of Health Sciences and Pharmacy, St Louis, MO 63110, USA.; Department of Pharmaceutical and Administrative Sciences, University of Health Sciences and Pharmacy, St Louis, MO 63110, USA., Zhao P; Department of Anesthesiology, Washington University in St Louis, St Louis, MO, USA. belgendy@wustl.edu.; Center for Clinical Pharmacology, Washington University School of Medicine and University of Health Sciences and Pharmacy, St Louis, MO 63110, USA.; Department of Pharmaceutical and Administrative Sciences, University of Health Sciences and Pharmacy, St Louis, MO 63110, USA., Koelblen T; University of Florida Genetics Institute, University of Florida School of Medicine, Gainesville, FL, USA.; University of Florida College of Pharmacy, Department of Cellular and Systems Pharmacology, Gainesville, FL, USA., Hegazy L; Center for Clinical Pharmacology, Washington University School of Medicine and University of Health Sciences and Pharmacy, St Louis, MO 63110, USA.; Department of Pharmaceutical and Administrative Sciences, University of Health Sciences and Pharmacy, St Louis, MO 63110, USA., Burris TP; University of Florida Genetics Institute, University of Florida School of Medicine, Gainesville, FL, USA.; University of Florida College of Pharmacy, Department of Cellular and Systems Pharmacology, Gainesville, FL, USA., Elgendy B; Department of Anesthesiology, Washington University in St Louis, St Louis, MO, USA. belgendy@wustl.edu.; Center for Clinical Pharmacology, Washington University School of Medicine and University of Health Sciences and Pharmacy, St Louis, MO 63110, USA.; Department of Pharmaceutical and Administrative Sciences, University of Health Sciences and Pharmacy, St Louis, MO 63110, USA.
Source: Organic & biomolecular chemistry [Org Biomol Chem] 2025 Aug 06; Vol. 23 (31), pp. 7298-7313. Date of Electronic Publication: 2025 Aug 06.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101154995 Publication Model: Electronic Cited Medium: Internet ISSN: 1477-0539 (Electronic) Linking ISSN: 14770520 NLM ISO Abbreviation: Org Biomol Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Iodine-promoted oxidative cross-coupling for the synthesis of (E)-2-(3-oxo-3-phenylprop-1-en-1-yl)-3-phenylquinazolin-4(3H)-one via C-H activation: development of synthetic TLX agonists.
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  Data: <searchLink fieldCode="AU" term="%22Maram+L%22">Maram L</searchLink>; Department of Anesthesiology, Washington University in St Louis, St Louis, MO, USA. belgendy@wustl.edu.; Center for Clinical Pharmacology, Washington University School of Medicine and University of Health Sciences and Pharmacy, St Louis, MO 63110, USA.; Department of Pharmaceutical and Administrative Sciences, University of Health Sciences and Pharmacy, St Louis, MO 63110, USA.<br /><searchLink fieldCode="AU" term="%22Zhao+P%22">Zhao P</searchLink>; Department of Anesthesiology, Washington University in St Louis, St Louis, MO, USA. belgendy@wustl.edu.; Center for Clinical Pharmacology, Washington University School of Medicine and University of Health Sciences and Pharmacy, St Louis, MO 63110, USA.; Department of Pharmaceutical and Administrative Sciences, University of Health Sciences and Pharmacy, St Louis, MO 63110, USA.<br /><searchLink fieldCode="AU" term="%22Koelblen+T%22">Koelblen T</searchLink>; University of Florida Genetics Institute, University of Florida School of Medicine, Gainesville, FL, USA.; University of Florida College of Pharmacy, Department of Cellular and Systems Pharmacology, Gainesville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Hegazy+L%22">Hegazy L</searchLink>; Center for Clinical Pharmacology, Washington University School of Medicine and University of Health Sciences and Pharmacy, St Louis, MO 63110, USA.; Department of Pharmaceutical and Administrative Sciences, University of Health Sciences and Pharmacy, St Louis, MO 63110, USA.<br /><searchLink fieldCode="AU" term="%22Burris+TP%22">Burris TP</searchLink>; University of Florida Genetics Institute, University of Florida School of Medicine, Gainesville, FL, USA.; University of Florida College of Pharmacy, Department of Cellular and Systems Pharmacology, Gainesville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Elgendy+B%22">Elgendy B</searchLink>; Department of Anesthesiology, Washington University in St Louis, St Louis, MO, USA. belgendy@wustl.edu.; Center for Clinical Pharmacology, Washington University School of Medicine and University of Health Sciences and Pharmacy, St Louis, MO 63110, USA.; Department of Pharmaceutical and Administrative Sciences, University of Health Sciences and Pharmacy, St Louis, MO 63110, USA.
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  Data: <searchLink fieldCode="JN" term="%22101154995%22">Organic & biomolecular chemistry</searchLink> [Org Biomol Chem] 2025 Aug 06; Vol. 23 (31), pp. 7298-7313. <i>Date of Electronic Publication: </i>2025 Aug 06.
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        Value: 10.1039/d5ob00672d
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              Text: 2025 Aug 06
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