ADMET, docking, anticancer evaluations, design and synthesis of pyrazolo[1,5-a]pyrimidines substituted with furan and phenyldiazene as dual EGFRT790M and VEGFR-2 inhibitors.
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| Title: | ADMET, docking, anticancer evaluations, design and synthesis of pyrazolo[1,5-a]pyrimidines substituted with furan and phenyldiazene as dual EGFRT790M and VEGFR-2 inhibitors. |
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| Authors: | Alsulaimany M; Department of Pharmacognosy and Pharmaceutical Chemistry, College of Pharmacy, Taibah University, Madinah, Saudi Arabia., Athary Abdulhaleem M F; Department of Biology, Faculty of Science, Umm Al-Qura University, 21955 Makkah, Saudi Arabia., Alghamdi R; Department of Pharmacognosy and Pharmaceutical Chemistry, College of Pharmacy, Taibah University, Madinah, Saudi Arabia., Abd El-Sattar NEA; Department of Chemistry, Faculty of Science, Ain Shams University, Abbassia, Cairo, Egypt; Basic & Medical Sciences Department, Faculty of Dentistry, Alryada University for Science & Technology, Egypt., Almadani SA; Department of Pharmacology and Toxicology, College of Pharmacy, Taibah University, Madinah, Saudi Arabia., Samman WA; Department of Pharmacology and Toxicology, College of Pharmacy, Taibah University, Madinah, Saudi Arabia., Alharbi HY; Department of Chemistry, College of Science, Taibah University, Madinah, Saudi Arabia., Aljohani MS; Department of Chemistry, College of Science, Taibah University, Madinah, Saudi Arabia., Tayeb SM; Department of Pharmaceutical Science, College of Pharmacy, Umm Al-Qura University, Makkah 24381, Saudi Arabia., Nasr T; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Helwan University, Ain-Helwan, Cairo 11795, Egypt; Medicinal Chemistry Department, Faculty of Pharmacy, Egypt-Japan University of Science and Technology (E-JUST), P.O. 21934, Alexandria, Egypt., El-Adl K; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Heliopolis University for Sustainable Development, Cairo, Egypt; Pharmaceutical Medicinal Chemistry and Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, 11884 Cairo, Egypt. Electronic address: khaled.eladl@hu.edu.eg., Anwer KE; Department of Chemistry, Faculty of Science, Ain Shams University, Abbassia, Cairo, Egypt. |
| Source: | Bioorganic chemistry [Bioorg Chem] 2025 Aug; Vol. 163, pp. 108746. Date of Electronic Publication: 2025 Jul 14. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 40680557 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: ADMET, docking, anticancer evaluations, design and synthesis of pyrazolo[1,5-a]pyrimidines substituted with furan and phenyldiazene as dual EGFR<superscript>T790M</superscript> and VEGFR-2 inhibitors. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Alsulaimany+M%22">Alsulaimany M</searchLink>; Department of Pharmacognosy and Pharmaceutical Chemistry, College of Pharmacy, Taibah University, Madinah, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Athary+Abdulhaleem+M+F%22">Athary Abdulhaleem M F</searchLink>; Department of Biology, Faculty of Science, Umm Al-Qura University, 21955 Makkah, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Alghamdi+R%22">Alghamdi R</searchLink>; Department of Pharmacognosy and Pharmaceutical Chemistry, College of Pharmacy, Taibah University, Madinah, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Abd+El-Sattar+NEA%22">Abd El-Sattar NEA</searchLink>; Department of Chemistry, Faculty of Science, Ain Shams University, Abbassia, Cairo, Egypt; Basic & Medical Sciences Department, Faculty of Dentistry, Alryada University for Science & Technology, Egypt.<br /><searchLink fieldCode="AU" term="%22Almadani+SA%22">Almadani SA</searchLink>; Department of Pharmacology and Toxicology, College of Pharmacy, Taibah University, Madinah, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Samman+WA%22">Samman WA</searchLink>; Department of Pharmacology and Toxicology, College of Pharmacy, Taibah University, Madinah, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Alharbi+HY%22">Alharbi HY</searchLink>; Department of Chemistry, College of Science, Taibah University, Madinah, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Aljohani+MS%22">Aljohani MS</searchLink>; Department of Chemistry, College of Science, Taibah University, Madinah, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Tayeb+SM%22">Tayeb SM</searchLink>; Department of Pharmaceutical Science, College of Pharmacy, Umm Al-Qura University, Makkah 24381, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Nasr+T%22">Nasr T</searchLink>; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Helwan University, Ain-Helwan, Cairo 11795, Egypt; Medicinal Chemistry Department, Faculty of Pharmacy, Egypt-Japan University of Science and Technology (E-JUST), P.O. 21934, Alexandria, Egypt.<br /><searchLink fieldCode="AU" term="%22El-Adl+K%22">El-Adl K</searchLink>; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Heliopolis University for Sustainable Development, Cairo, Egypt; Pharmaceutical Medicinal Chemistry and Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, 11884 Cairo, Egypt. Electronic address: khaled.eladl@hu.edu.eg.<br /><searchLink fieldCode="AU" term="%22Anwer+KE%22">Anwer KE</searchLink>; Department of Chemistry, Faculty of Science, Ain Shams University, Abbassia, Cairo, Egypt. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%221303703%22">Bioorganic chemistry</searchLink> [Bioorg Chem] 2025 Aug; Vol. 163, pp. 108746. <i>Date of Electronic Publication: </i>2025 Jul 14. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>1303703 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1090-2120 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200452068%22">00452068 </searchLink><i>NLM ISO Abbreviation: </i>Bioorg Chem <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=40680557 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.bioorg.2025.108746 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 108746 Titles: – TitleFull: ADMET, docking, anticancer evaluations, design and synthesis of pyrazolo[1,5-a]pyrimidines substituted with furan and phenyldiazene as dual EGFRT790M and VEGFR-2 inhibitors. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Alsulaimany M – PersonEntity: Name: NameFull: Athary Abdulhaleem M F – PersonEntity: Name: NameFull: Alghamdi R – PersonEntity: Name: NameFull: Abd El-Sattar NEA – PersonEntity: Name: NameFull: Almadani SA – PersonEntity: Name: NameFull: Samman WA – PersonEntity: Name: NameFull: Alharbi HY – PersonEntity: Name: NameFull: Aljohani MS – PersonEntity: Name: NameFull: Tayeb SM – PersonEntity: Name: NameFull: Nasr T – PersonEntity: Name: NameFull: El-Adl K – PersonEntity: Name: NameFull: Anwer KE IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 08 Text: 2025 Aug Type: published Y: 2025 Identifiers: – Type: issn-electronic Value: 1090-2120 Numbering: – Type: volume Value: 163 Titles: – TitleFull: Bioorganic chemistry Type: main |
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