Structural mechanisms behind the neutralisation of long-chain α-neurotoxins by broadly neutralising VHHs discovered using a consensus antigen.

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Title: Structural mechanisms behind the neutralisation of long-chain α-neurotoxins by broadly neutralising VHHs discovered using a consensus antigen.
Authors: Damsbo A; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark.; Bactolife A/S, Copenhagen, Denmark., Burlet NJ; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark., Fernández-Quintero ML; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark.; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Benard-Valle M; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark., Overath MD; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark., Guadarrama-Martínez A; Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, México., Vlamynck A; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark., Bisbo I; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark., Villalobos C; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark., Tulika T; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark., Alagón A; Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, México., Loeffler JR; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Ward AB; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Boddum K; Sophion Bioscience A/S, Ballerup, Denmark., Morth JP; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark., Rivera-de-Torre E; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark. erdto@dtu.dk., Laustsen AH; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark. ahola@bio.dtu.dk.
Source: Communications chemistry [Commun Chem] 2025 Jul 19; Vol. 8 (1), pp. 209. Date of Electronic Publication: 2025 Jul 19.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: England NLM ID: 101725670 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3669 (Electronic) Linking ISSN: 23993669 NLM ISO Abbreviation: Commun Chem Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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ISSN:2399-3669
DOI:10.1038/s42004-025-01600-4