Structural mechanisms behind the neutralisation of long-chain α-neurotoxins by broadly neutralising VHHs discovered using a consensus antigen.

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Title: Structural mechanisms behind the neutralisation of long-chain α-neurotoxins by broadly neutralising VHHs discovered using a consensus antigen.
Authors: Damsbo A; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark.; Bactolife A/S, Copenhagen, Denmark., Burlet NJ; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark., Fernández-Quintero ML; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark.; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Benard-Valle M; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark., Overath MD; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark., Guadarrama-Martínez A; Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, México., Vlamynck A; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark., Bisbo I; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark., Villalobos C; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark., Tulika T; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark., Alagón A; Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, México., Loeffler JR; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Ward AB; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Boddum K; Sophion Bioscience A/S, Ballerup, Denmark., Morth JP; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark., Rivera-de-Torre E; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark. erdto@dtu.dk., Laustsen AH; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark. ahola@bio.dtu.dk.
Source: Communications chemistry [Commun Chem] 2025 Jul 19; Vol. 8 (1), pp. 209. Date of Electronic Publication: 2025 Jul 19.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: England NLM ID: 101725670 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3669 (Electronic) Linking ISSN: 23993669 NLM ISO Abbreviation: Commun Chem Subsets: PubMed not MEDLINE
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  Data: Structural mechanisms behind the neutralisation of long-chain α-neurotoxins by broadly neutralising V<subscript>H</subscript>Hs discovered using a consensus antigen.
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  Data: <searchLink fieldCode="AU" term="%22Damsbo+A%22">Damsbo A</searchLink>; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark.; Bactolife A/S, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Burlet+NJ%22">Burlet NJ</searchLink>; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark.<br /><searchLink fieldCode="AU" term="%22Fernández-Quintero+ML%22">Fernández-Quintero ML</searchLink>; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark.; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Benard-Valle+M%22">Benard-Valle M</searchLink>; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark.<br /><searchLink fieldCode="AU" term="%22Overath+MD%22">Overath MD</searchLink>; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark.<br /><searchLink fieldCode="AU" term="%22Guadarrama-Martínez+A%22">Guadarrama-Martínez A</searchLink>; Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, México.<br /><searchLink fieldCode="AU" term="%22Vlamynck+A%22">Vlamynck A</searchLink>; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark.<br /><searchLink fieldCode="AU" term="%22Bisbo+I%22">Bisbo I</searchLink>; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark.<br /><searchLink fieldCode="AU" term="%22Villalobos+C%22">Villalobos C</searchLink>; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark.<br /><searchLink fieldCode="AU" term="%22Tulika+T%22">Tulika T</searchLink>; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark.<br /><searchLink fieldCode="AU" term="%22Alagón+A%22">Alagón A</searchLink>; Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, México.<br /><searchLink fieldCode="AU" term="%22Loeffler+JR%22">Loeffler JR</searchLink>; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Ward+AB%22">Ward AB</searchLink>; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Boddum+K%22">Boddum K</searchLink>; Sophion Bioscience A/S, Ballerup, Denmark.<br /><searchLink fieldCode="AU" term="%22Morth+JP%22">Morth JP</searchLink>; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark.<br /><searchLink fieldCode="AU" term="%22Rivera-de-Torre+E%22">Rivera-de-Torre E</searchLink>; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark. erdto@dtu.dk.<br /><searchLink fieldCode="AU" term="%22Laustsen+AH%22">Laustsen AH</searchLink>; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark. ahola@bio.dtu.dk.
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  Data: <searchLink fieldCode="JN" term="%22101725670%22">Communications chemistry</searchLink> [Commun Chem] 2025 Jul 19; Vol. 8 (1), pp. 209. <i>Date of Electronic Publication: </i>2025 Jul 19.
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