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Physiologically based pharmacokinetic modeling of aldehyde oxidase drug-drug interactions mediated by erlotinib.

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Title: Physiologically based pharmacokinetic modeling of aldehyde oxidase drug-drug interactions mediated by erlotinib.
Authors: Heikkinen AT; Certara Predictive Technologies, Sheffield, United Kingdom., De Sousa Mendes M; Certara Predictive Technologies, Sheffield, United Kingdom., West MA; Pharmacokinetics, Dynamics, and Metabolism, Pfizer Inc., Groton, Connecticut., Yee SW; Pharmacokinetics, Dynamics, and Metabolism, Pfizer Inc., Groton, Connecticut., Gardner I; Certara Predictive Technologies, Sheffield, United Kingdom., Tang LWT; Pharmacokinetics, Dynamics, and Metabolism, Pfizer Inc., Groton, Connecticut. Electronic address: lloydweitat.tang@pfizer.com.
Source: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2025 Aug; Vol. 53 (8), pp. 100113. Date of Electronic Publication: 2025 Jun 23.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9421550 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-009X (Electronic) Linking ISSN: 00909556 NLM ISO Abbreviation: Drug Metab Dispos Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: <searchLink fieldCode="AU" term="%22Heikkinen+AT%22">Heikkinen AT</searchLink>; Certara Predictive Technologies, Sheffield, United Kingdom.<br /><searchLink fieldCode="AU" term="%22De+Sousa+Mendes+M%22">De Sousa Mendes M</searchLink>; Certara Predictive Technologies, Sheffield, United Kingdom.<br /><searchLink fieldCode="AU" term="%22West+MA%22">West MA</searchLink>; Pharmacokinetics, Dynamics, and Metabolism, Pfizer Inc., Groton, Connecticut.<br /><searchLink fieldCode="AU" term="%22Yee+SW%22">Yee SW</searchLink>; Pharmacokinetics, Dynamics, and Metabolism, Pfizer Inc., Groton, Connecticut.<br /><searchLink fieldCode="AU" term="%22Gardner+I%22">Gardner I</searchLink>; Certara Predictive Technologies, Sheffield, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Tang+LWT%22">Tang LWT</searchLink>; Pharmacokinetics, Dynamics, and Metabolism, Pfizer Inc., Groton, Connecticut. Electronic address: lloydweitat.tang@pfizer.com.
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        Value: 10.1016/j.dmd.2025.100113
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        Text: English
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              Text: 2025 Aug
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