Lung Single-Cell Transcriptomics Reveal Diverging Pathobiology and Opportunities for Precision Targeting in Scleroderma-Associated Versus Idiopathic Pulmonary Arterial Hypertension.
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| Title: | Lung Single-Cell Transcriptomics Reveal Diverging Pathobiology and Opportunities for Precision Targeting in Scleroderma-Associated Versus Idiopathic Pulmonary Arterial Hypertension. |
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| Authors: | Tuhy T; Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD (T.T., J.C.C., M.P., C.C., S.E.N., S.L.K., D.T.R., M.P.C., T.M.K., S.C.M., P.M.H., L.A.S., K.S., C.E.S.)., Coursen JC; Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD (T.T., J.C.C., M.P., C.C., S.E.N., S.L.K., D.T.R., M.P.C., T.M.K., S.C.M., P.M.H., L.A.S., K.S., C.E.S.)., Graves T; Division of Pulmonary Medicine, Indiana University, Indianapolis (T.G., M.A.A.)., Patatanian M; Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD (T.T., J.C.C., M.P., C.C., S.E.N., S.L.K., D.T.R., M.P.C., T.M.K., S.C.M., P.M.H., L.A.S., K.S., C.E.S.)., Cherry C; Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD (T.T., J.C.C., M.P., C.C., S.E.N., S.L.K., D.T.R., M.P.C., T.M.K., S.C.M., P.M.H., L.A.S., K.S., C.E.S.)., Niedermeyer SE; Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD (T.T., J.C.C., M.P., C.C., S.E.N., S.L.K., D.T.R., M.P.C., T.M.K., S.C.M., P.M.H., L.A.S., K.S., C.E.S.)., Khan SL; Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD (T.T., J.C.C., M.P., C.C., S.E.N., S.L.K., D.T.R., M.P.C., T.M.K., S.C.M., P.M.H., L.A.S., K.S., C.E.S.)., Rosen DT; Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD (T.T., J.C.C., M.P., C.C., S.E.N., S.L.K., D.T.R., M.P.C., T.M.K., S.C.M., P.M.H., L.A.S., K.S., C.E.S.)., Croglio MP; Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD (T.T., J.C.C., M.P., C.C., S.E.N., S.L.K., D.T.R., M.P.C., T.M.K., S.C.M., P.M.H., L.A.S., K.S., C.E.S.)., Elnashar M; Faculty of Medicine, Ain Shams University, Cairo, Egypt (M.E.)., Kolb TM; Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD (T.T., J.C.C., M.P., C.C., S.E.N., S.L.K., D.T.R., M.P.C., T.M.K., S.C.M., P.M.H., L.A.S., K.S., C.E.S.)., Mathai SC; Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD (T.T., J.C.C., M.P., C.C., S.E.N., S.L.K., D.T.R., M.P.C., T.M.K., S.C.M., P.M.H., L.A.S., K.S., C.E.S.)., Damico RL; Division of Pulmonary and Critical Care Medicine, University of Miami, FL (R.L.D.)., Hassoun PM; Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD (T.T., J.C.C., M.P., C.C., S.E.N., S.L.K., D.T.R., M.P.C., T.M.K., S.C.M., P.M.H., L.A.S., K.S., C.E.S.)., Shimoda LA; Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD (T.T., J.C.C., M.P., C.C., S.E.N., S.L.K., D.T.R., M.P.C., T.M.K., S.C.M., P.M.H., L.A.S., K.S., C.E.S.)., Suresh K; Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD (T.T., J.C.C., M.P., C.C., S.E.N., S.L.K., D.T.R., M.P.C., T.M.K., S.C.M., P.M.H., L.A.S., K.S., C.E.S.)., Aldred MA; Division of Pulmonary Medicine, Indiana University, Indianapolis (T.G., M.A.A.)., Simpson CE; Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD (T.T., J.C.C., M.P., C.C., S.E.N., S.L.K., D.T.R., M.P.C., T.M.K., S.C.M., P.M.H., L.A.S., K.S., C.E.S.). |
| Source: | Circulation. Genomic and precision medicine [Circ Genom Precis Med] 2025 Aug; Vol. 18 (4), pp. e004936. Date of Electronic Publication: 2025 Jul 21. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 101714113 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2574-8300 (Electronic) Linking ISSN: 25748300 NLM ISO Abbreviation: Circ Genom Precis Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 40686216 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Lung Single-Cell Transcriptomics Reveal Diverging Pathobiology and Opportunities for Precision Targeting in Scleroderma-Associated Versus Idiopathic Pulmonary Arterial Hypertension. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Tuhy+T%22">Tuhy T</searchLink>; Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD (T.T., J.C.C., M.P., C.C., S.E.N., S.L.K., D.T.R., M.P.C., T.M.K., S.C.M., P.M.H., L.A.S., K.S., C.E.S.).<br /><searchLink fieldCode="AU" term="%22Coursen+JC%22">Coursen JC</searchLink>; Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD (T.T., J.C.C., M.P., C.C., S.E.N., S.L.K., D.T.R., M.P.C., T.M.K., S.C.M., P.M.H., L.A.S., K.S., C.E.S.).<br /><searchLink fieldCode="AU" term="%22Graves+T%22">Graves T</searchLink>; Division of Pulmonary Medicine, Indiana University, Indianapolis (T.G., M.A.A.).<br /><searchLink fieldCode="AU" term="%22Patatanian+M%22">Patatanian M</searchLink>; Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD (T.T., J.C.C., M.P., C.C., S.E.N., S.L.K., D.T.R., M.P.C., T.M.K., S.C.M., P.M.H., L.A.S., K.S., C.E.S.).<br /><searchLink fieldCode="AU" term="%22Cherry+C%22">Cherry C</searchLink>; Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD (T.T., J.C.C., M.P., C.C., S.E.N., S.L.K., D.T.R., M.P.C., T.M.K., S.C.M., P.M.H., L.A.S., K.S., C.E.S.).<br /><searchLink fieldCode="AU" term="%22Niedermeyer+SE%22">Niedermeyer SE</searchLink>; Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD (T.T., J.C.C., M.P., C.C., S.E.N., S.L.K., D.T.R., M.P.C., T.M.K., S.C.M., P.M.H., L.A.S., K.S., C.E.S.).<br /><searchLink fieldCode="AU" term="%22Khan+SL%22">Khan SL</searchLink>; Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD (T.T., J.C.C., M.P., C.C., S.E.N., S.L.K., D.T.R., M.P.C., T.M.K., S.C.M., P.M.H., L.A.S., K.S., C.E.S.).<br /><searchLink fieldCode="AU" term="%22Rosen+DT%22">Rosen DT</searchLink>; Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD (T.T., J.C.C., M.P., C.C., S.E.N., S.L.K., D.T.R., M.P.C., T.M.K., S.C.M., P.M.H., L.A.S., K.S., C.E.S.).<br /><searchLink fieldCode="AU" term="%22Croglio+MP%22">Croglio MP</searchLink>; Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD (T.T., J.C.C., M.P., C.C., S.E.N., S.L.K., D.T.R., M.P.C., T.M.K., S.C.M., P.M.H., L.A.S., K.S., C.E.S.).<br /><searchLink fieldCode="AU" term="%22Elnashar+M%22">Elnashar M</searchLink>; Faculty of Medicine, Ain Shams University, Cairo, Egypt (M.E.).<br /><searchLink fieldCode="AU" term="%22Kolb+TM%22">Kolb TM</searchLink>; Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD (T.T., J.C.C., M.P., C.C., S.E.N., S.L.K., D.T.R., M.P.C., T.M.K., S.C.M., P.M.H., L.A.S., K.S., C.E.S.).<br /><searchLink fieldCode="AU" term="%22Mathai+SC%22">Mathai SC</searchLink>; Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD (T.T., J.C.C., M.P., C.C., S.E.N., S.L.K., D.T.R., M.P.C., T.M.K., S.C.M., P.M.H., L.A.S., K.S., C.E.S.).<br /><searchLink fieldCode="AU" term="%22Damico+RL%22">Damico RL</searchLink>; Division of Pulmonary and Critical Care Medicine, University of Miami, FL (R.L.D.).<br /><searchLink fieldCode="AU" term="%22Hassoun+PM%22">Hassoun PM</searchLink>; Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD (T.T., J.C.C., M.P., C.C., S.E.N., S.L.K., D.T.R., M.P.C., T.M.K., S.C.M., P.M.H., L.A.S., K.S., C.E.S.).<br /><searchLink fieldCode="AU" term="%22Shimoda+LA%22">Shimoda LA</searchLink>; Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD (T.T., J.C.C., M.P., C.C., S.E.N., S.L.K., D.T.R., M.P.C., T.M.K., S.C.M., P.M.H., L.A.S., K.S., C.E.S.).<br /><searchLink fieldCode="AU" term="%22Suresh+K%22">Suresh K</searchLink>; Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD (T.T., J.C.C., M.P., C.C., S.E.N., S.L.K., D.T.R., M.P.C., T.M.K., S.C.M., P.M.H., L.A.S., K.S., C.E.S.).<br /><searchLink fieldCode="AU" term="%22Aldred+MA%22">Aldred MA</searchLink>; Division of Pulmonary Medicine, Indiana University, Indianapolis (T.G., M.A.A.).<br /><searchLink fieldCode="AU" term="%22Simpson+CE%22">Simpson CE</searchLink>; Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD (T.T., J.C.C., M.P., C.C., S.E.N., S.L.K., D.T.R., M.P.C., T.M.K., S.C.M., P.M.H., L.A.S., K.S., C.E.S.). – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101714113%22">Circulation. Genomic and precision medicine</searchLink> [Circ Genom Precis Med] 2025 Aug; Vol. 18 (4), pp. e004936. <i>Date of Electronic Publication: </i>2025 Jul 21. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Lippincott+Williams+%26+Wilkins%22">Lippincott Williams & Wilkins </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101714113 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2574-8300 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2225748300%22">25748300 </searchLink><i>NLM ISO Abbreviation: </i>Circ Genom Precis Med <i>Subsets: </i>MEDLINE |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1161/CIRCGEN.124.004936 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: e004936 Titles: – TitleFull: Lung Single-Cell Transcriptomics Reveal Diverging Pathobiology and Opportunities for Precision Targeting in Scleroderma-Associated Versus Idiopathic Pulmonary Arterial Hypertension. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Tuhy T – PersonEntity: Name: NameFull: Coursen JC – PersonEntity: Name: NameFull: Graves T – PersonEntity: Name: NameFull: Patatanian M – PersonEntity: Name: NameFull: Cherry C – PersonEntity: Name: NameFull: Niedermeyer SE – PersonEntity: Name: NameFull: Khan SL – PersonEntity: Name: NameFull: Rosen DT – PersonEntity: Name: NameFull: Croglio MP – PersonEntity: Name: NameFull: Elnashar M – PersonEntity: Name: NameFull: Kolb TM – PersonEntity: Name: NameFull: Mathai SC – PersonEntity: Name: NameFull: Damico RL – PersonEntity: Name: NameFull: Hassoun PM – PersonEntity: Name: NameFull: Shimoda LA – PersonEntity: Name: NameFull: Suresh K – PersonEntity: Name: NameFull: Aldred MA – PersonEntity: Name: NameFull: Simpson CE IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 08 Text: 2025 Aug Type: published Y: 2025 Identifiers: – Type: issn-electronic Value: 2574-8300 Numbering: – Type: volume Value: 18 – Type: issue Value: 4 Titles: – TitleFull: Circulation. Genomic and precision medicine Type: main |
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