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Utilizing rat kidney gene co-expression networks to enhance safety assessment biomarker identification and human translation.

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Title: Utilizing rat kidney gene co-expression networks to enhance safety assessment biomarker identification and human translation.
Authors: Kunnen SJ; Leiden University, Leiden Academic Centre for Drug Research (LACDR), Division of Cell Systems and Drug Safety, Leiden, the Netherlands., Callegaro G; Leiden University, Leiden Academic Centre for Drug Research (LACDR), Division of Cell Systems and Drug Safety, Leiden, the Netherlands., Sutherland JJ; Vesalius Therapeutics, Cambridge, MA, USA., Trairatphisan P; Sanofi, R&D Preclinical Safety, Industriepark Hoechst, Frankfurt am Main, Germany.; Heidelberg University, Faculty of Medicine, Institute for Computational Biomedicine, Heidelberg, Germany., van Kessel HW; Leiden University, Leiden Academic Centre for Drug Research (LACDR), Division of Cell Systems and Drug Safety, Leiden, the Netherlands., Wijaya LS; Leiden University, Leiden Academic Centre for Drug Research (LACDR), Division of Cell Systems and Drug Safety, Leiden, the Netherlands., Chung G; Newcells Biotech, Newcastle, UK., Pye K; Newcells Biotech, Newcastle, UK., Goldstein KM; Lilly Research Laboratories, Eli Lilly and Company Ltd, Indianapolis, IN, USA., Teague CR; GSK, Clinical Pharmacology and Experimental Medicine, Stevenage, UK., Fisher CP; GSK, Target and Systems Safety, Nonclinical Safety, Stevenage, UK., Saez-Rodriguez J; Heidelberg University, Faculty of Medicine, Institute for Computational Biomedicine, Heidelberg, Germany., Brown C; Newcells Biotech, Newcastle, UK., Elmore SA; ElmorePathology, LLC, Chapel Hill, NC, USA., Heinz-Taheny KM; Lilly Research Laboratories, Eli Lilly and Company Ltd, Indianapolis, IN, USA., Stevens JL; Leiden University, Leiden Academic Centre for Drug Research (LACDR), Division of Cell Systems and Drug Safety, Leiden, the Netherlands., van de Water B; Leiden University, Leiden Academic Centre for Drug Research (LACDR), Division of Cell Systems and Drug Safety, Leiden, the Netherlands.
Source: IScience [iScience] 2025 Jun 21; Vol. 28 (7), pp. 112978. Date of Electronic Publication: 2025 Jun 21 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101724038 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-0042 (Electronic) Linking ISSN: 25890042 NLM ISO Abbreviation: iScience Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Kunnen+SJ%22">Kunnen SJ</searchLink>; Leiden University, Leiden Academic Centre for Drug Research (LACDR), Division of Cell Systems and Drug Safety, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Callegaro+G%22">Callegaro G</searchLink>; Leiden University, Leiden Academic Centre for Drug Research (LACDR), Division of Cell Systems and Drug Safety, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Sutherland+JJ%22">Sutherland JJ</searchLink>; Vesalius Therapeutics, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Trairatphisan+P%22">Trairatphisan P</searchLink>; Sanofi, R&D Preclinical Safety, Industriepark Hoechst, Frankfurt am Main, Germany.; Heidelberg University, Faculty of Medicine, Institute for Computational Biomedicine, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22van+Kessel+HW%22">van Kessel HW</searchLink>; Leiden University, Leiden Academic Centre for Drug Research (LACDR), Division of Cell Systems and Drug Safety, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Wijaya+LS%22">Wijaya LS</searchLink>; Leiden University, Leiden Academic Centre for Drug Research (LACDR), Division of Cell Systems and Drug Safety, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Chung+G%22">Chung G</searchLink>; Newcells Biotech, Newcastle, UK.<br /><searchLink fieldCode="AU" term="%22Pye+K%22">Pye K</searchLink>; Newcells Biotech, Newcastle, UK.<br /><searchLink fieldCode="AU" term="%22Goldstein+KM%22">Goldstein KM</searchLink>; Lilly Research Laboratories, Eli Lilly and Company Ltd, Indianapolis, IN, USA.<br /><searchLink fieldCode="AU" term="%22Teague+CR%22">Teague CR</searchLink>; GSK, Clinical Pharmacology and Experimental Medicine, Stevenage, UK.<br /><searchLink fieldCode="AU" term="%22Fisher+CP%22">Fisher CP</searchLink>; GSK, Target and Systems Safety, Nonclinical Safety, Stevenage, UK.<br /><searchLink fieldCode="AU" term="%22Saez-Rodriguez+J%22">Saez-Rodriguez J</searchLink>; Heidelberg University, Faculty of Medicine, Institute for Computational Biomedicine, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Brown+C%22">Brown C</searchLink>; Newcells Biotech, Newcastle, UK.<br /><searchLink fieldCode="AU" term="%22Elmore+SA%22">Elmore SA</searchLink>; ElmorePathology, LLC, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Heinz-Taheny+KM%22">Heinz-Taheny KM</searchLink>; Lilly Research Laboratories, Eli Lilly and Company Ltd, Indianapolis, IN, USA.<br /><searchLink fieldCode="AU" term="%22Stevens+JL%22">Stevens JL</searchLink>; Leiden University, Leiden Academic Centre for Drug Research (LACDR), Division of Cell Systems and Drug Safety, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+de+Water+B%22">van de Water B</searchLink>; Leiden University, Leiden Academic Centre for Drug Research (LACDR), Division of Cell Systems and Drug Safety, Leiden, the Netherlands.
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