Human fetal kidney organoids model early human nephrogenesis and Notch-driven cell fate.

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Title: Human fetal kidney organoids model early human nephrogenesis and Notch-driven cell fate.
Authors: Namestnikov M; The Pediatric Stem Cell Research Institute and Pediatric Nephrology Division, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel HaShomer, Israel.; Gray Faculty of Medical & Health Sciences, Tel Aviv University, Ramat Aviv, Tel Aviv, 69978, Israel.; Sagol Center for Regenerative Medicine (SCRM), Tel Aviv University, Ramat Aviv, Tel Aviv, Israel., Cohen-Zontag O; The Pediatric Stem Cell Research Institute and Pediatric Nephrology Division, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel HaShomer, Israel.; Sagol Center for Regenerative Medicine (SCRM), Tel Aviv University, Ramat Aviv, Tel Aviv, Israel., Omer D; The Pediatric Stem Cell Research Institute and Pediatric Nephrology Division, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel HaShomer, Israel., Gnatek Y; The Pediatric Stem Cell Research Institute and Pediatric Nephrology Division, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel HaShomer, Israel., Goldberg S; The Pediatric Stem Cell Research Institute and Pediatric Nephrology Division, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel HaShomer, Israel., Vincent T; Department of Medicine, Division of Nephrology, Institute for Stem Cells and Regenerative Medicine, and Kidney Research Institute, University of Washington, Seattle, WA, USA., Singh S; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, 7610001, Israel., Shiber Y; Department of Obstetrics and Gynecology, Assaf Harofeh Medical Center, Zerifin, Israel., Rafaeli Yehudai T; Department of Obstetrics and Gynecology, Assaf Harofeh Medical Center, Zerifin, Israel., Volkov H; The Edmond J. Safra Center for Bioinformatics, Tel-Aviv University, Tel Aviv, Israel., Folkman Genet D; The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel., Urbach A; The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel., Polak-Charcon S; Pathology Department, Sheba Medical Center, Tel HaShomer, Israel., Grinberg I; Pathology Department, Sheba Medical Center, Tel HaShomer, Israel., Pode-Shakked N; Gray Faculty of Medical & Health Sciences, Tel Aviv University, Ramat Aviv, Tel Aviv, 69978, Israel.; Pediatric Nephrology Unit, Dana Dwek Children's Hospital, Tel Aviv Medical Center, Tel Aviv, Israel., Weisz B; Gray Faculty of Medical & Health Sciences, Tel Aviv University, Ramat Aviv, Tel Aviv, 69978, Israel.; Institute of Obstetrical and Gynecological Imaging, Department of Obstetrics and Gynecology, Sheba Medical Center, Tel HaShomer, Israel., Vaknin Z; Department of Obstetrics and Gynecology, Assaf Harofeh Medical Center, Zerifin, Israel., Freedman BS; Department of Medicine, Division of Nephrology, Institute for Stem Cells and Regenerative Medicine, and Kidney Research Institute, University of Washington, Seattle, WA, USA., Dekel B; The Pediatric Stem Cell Research Institute and Pediatric Nephrology Division, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel HaShomer, Israel. binyamin.dekel@sheba.health.gov.il.; Gray Faculty of Medical & Health Sciences, Tel Aviv University, Ramat Aviv, Tel Aviv, 69978, Israel. binyamin.dekel@sheba.health.gov.il.; Sagol Center for Regenerative Medicine (SCRM), Tel Aviv University, Ramat Aviv, Tel Aviv, Israel. binyamin.dekel@sheba.health.gov.il.
Source: The EMBO journal [EMBO J] 2025 Sep; Vol. 44 (17), pp. 4681-4719. Date of Electronic Publication: 2025 Jul 21.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1460-2075
DOI:10.1038/s44318-025-00504-2