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Human fetal kidney organoids model early human nephrogenesis and Notch-driven cell fate.

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Title: Human fetal kidney organoids model early human nephrogenesis and Notch-driven cell fate.
Authors: Namestnikov M; The Pediatric Stem Cell Research Institute and Pediatric Nephrology Division, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel HaShomer, Israel.; Gray Faculty of Medical & Health Sciences, Tel Aviv University, Ramat Aviv, Tel Aviv, 69978, Israel.; Sagol Center for Regenerative Medicine (SCRM), Tel Aviv University, Ramat Aviv, Tel Aviv, Israel., Cohen-Zontag O; The Pediatric Stem Cell Research Institute and Pediatric Nephrology Division, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel HaShomer, Israel.; Sagol Center for Regenerative Medicine (SCRM), Tel Aviv University, Ramat Aviv, Tel Aviv, Israel., Omer D; The Pediatric Stem Cell Research Institute and Pediatric Nephrology Division, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel HaShomer, Israel., Gnatek Y; The Pediatric Stem Cell Research Institute and Pediatric Nephrology Division, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel HaShomer, Israel., Goldberg S; The Pediatric Stem Cell Research Institute and Pediatric Nephrology Division, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel HaShomer, Israel., Vincent T; Department of Medicine, Division of Nephrology, Institute for Stem Cells and Regenerative Medicine, and Kidney Research Institute, University of Washington, Seattle, WA, USA., Singh S; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, 7610001, Israel., Shiber Y; Department of Obstetrics and Gynecology, Assaf Harofeh Medical Center, Zerifin, Israel., Rafaeli Yehudai T; Department of Obstetrics and Gynecology, Assaf Harofeh Medical Center, Zerifin, Israel., Volkov H; The Edmond J. Safra Center for Bioinformatics, Tel-Aviv University, Tel Aviv, Israel., Folkman Genet D; The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel., Urbach A; The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel., Polak-Charcon S; Pathology Department, Sheba Medical Center, Tel HaShomer, Israel., Grinberg I; Pathology Department, Sheba Medical Center, Tel HaShomer, Israel., Pode-Shakked N; Gray Faculty of Medical & Health Sciences, Tel Aviv University, Ramat Aviv, Tel Aviv, 69978, Israel.; Pediatric Nephrology Unit, Dana Dwek Children's Hospital, Tel Aviv Medical Center, Tel Aviv, Israel., Weisz B; Gray Faculty of Medical & Health Sciences, Tel Aviv University, Ramat Aviv, Tel Aviv, 69978, Israel.; Institute of Obstetrical and Gynecological Imaging, Department of Obstetrics and Gynecology, Sheba Medical Center, Tel HaShomer, Israel., Vaknin Z; Department of Obstetrics and Gynecology, Assaf Harofeh Medical Center, Zerifin, Israel., Freedman BS; Department of Medicine, Division of Nephrology, Institute for Stem Cells and Regenerative Medicine, and Kidney Research Institute, University of Washington, Seattle, WA, USA., Dekel B; The Pediatric Stem Cell Research Institute and Pediatric Nephrology Division, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel HaShomer, Israel. binyamin.dekel@sheba.health.gov.il.; Gray Faculty of Medical & Health Sciences, Tel Aviv University, Ramat Aviv, Tel Aviv, 69978, Israel. binyamin.dekel@sheba.health.gov.il.; Sagol Center for Regenerative Medicine (SCRM), Tel Aviv University, Ramat Aviv, Tel Aviv, Israel. binyamin.dekel@sheba.health.gov.il.
Source: The EMBO journal [EMBO J] 2025 Sep; Vol. 44 (17), pp. 4681-4719. Date of Electronic Publication: 2025 Jul 21.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Human fetal kidney organoids model early human nephrogenesis and Notch-driven cell fate.
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  Data: <searchLink fieldCode="AU" term="%22Namestnikov+M%22">Namestnikov M</searchLink>; The Pediatric Stem Cell Research Institute and Pediatric Nephrology Division, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel HaShomer, Israel.; Gray Faculty of Medical & Health Sciences, Tel Aviv University, Ramat Aviv, Tel Aviv, 69978, Israel.; Sagol Center for Regenerative Medicine (SCRM), Tel Aviv University, Ramat Aviv, Tel Aviv, Israel.<br /><searchLink fieldCode="AU" term="%22Cohen-Zontag+O%22">Cohen-Zontag O</searchLink>; The Pediatric Stem Cell Research Institute and Pediatric Nephrology Division, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel HaShomer, Israel.; Sagol Center for Regenerative Medicine (SCRM), Tel Aviv University, Ramat Aviv, Tel Aviv, Israel.<br /><searchLink fieldCode="AU" term="%22Omer+D%22">Omer D</searchLink>; The Pediatric Stem Cell Research Institute and Pediatric Nephrology Division, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel HaShomer, Israel.<br /><searchLink fieldCode="AU" term="%22Gnatek+Y%22">Gnatek Y</searchLink>; The Pediatric Stem Cell Research Institute and Pediatric Nephrology Division, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel HaShomer, Israel.<br /><searchLink fieldCode="AU" term="%22Goldberg+S%22">Goldberg S</searchLink>; The Pediatric Stem Cell Research Institute and Pediatric Nephrology Division, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel HaShomer, Israel.<br /><searchLink fieldCode="AU" term="%22Vincent+T%22">Vincent T</searchLink>; Department of Medicine, Division of Nephrology, Institute for Stem Cells and Regenerative Medicine, and Kidney Research Institute, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Singh+S%22">Singh S</searchLink>; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, 7610001, Israel.<br /><searchLink fieldCode="AU" term="%22Shiber+Y%22">Shiber Y</searchLink>; Department of Obstetrics and Gynecology, Assaf Harofeh Medical Center, Zerifin, Israel.<br /><searchLink fieldCode="AU" term="%22Rafaeli+Yehudai+T%22">Rafaeli Yehudai T</searchLink>; Department of Obstetrics and Gynecology, Assaf Harofeh Medical Center, Zerifin, Israel.<br /><searchLink fieldCode="AU" term="%22Volkov+H%22">Volkov H</searchLink>; The Edmond J. Safra Center for Bioinformatics, Tel-Aviv University, Tel Aviv, Israel.<br /><searchLink fieldCode="AU" term="%22Folkman+Genet+D%22">Folkman Genet D</searchLink>; The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel.<br /><searchLink fieldCode="AU" term="%22Urbach+A%22">Urbach A</searchLink>; The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel.<br /><searchLink fieldCode="AU" term="%22Polak-Charcon+S%22">Polak-Charcon S</searchLink>; Pathology Department, Sheba Medical Center, Tel HaShomer, Israel.<br /><searchLink fieldCode="AU" term="%22Grinberg+I%22">Grinberg I</searchLink>; Pathology Department, Sheba Medical Center, Tel HaShomer, Israel.<br /><searchLink fieldCode="AU" term="%22Pode-Shakked+N%22">Pode-Shakked N</searchLink>; Gray Faculty of Medical & Health Sciences, Tel Aviv University, Ramat Aviv, Tel Aviv, 69978, Israel.; Pediatric Nephrology Unit, Dana Dwek Children's Hospital, Tel Aviv Medical Center, Tel Aviv, Israel.<br /><searchLink fieldCode="AU" term="%22Weisz+B%22">Weisz B</searchLink>; Gray Faculty of Medical & Health Sciences, Tel Aviv University, Ramat Aviv, Tel Aviv, 69978, Israel.; Institute of Obstetrical and Gynecological Imaging, Department of Obstetrics and Gynecology, Sheba Medical Center, Tel HaShomer, Israel.<br /><searchLink fieldCode="AU" term="%22Vaknin+Z%22">Vaknin Z</searchLink>; Department of Obstetrics and Gynecology, Assaf Harofeh Medical Center, Zerifin, Israel.<br /><searchLink fieldCode="AU" term="%22Freedman+BS%22">Freedman BS</searchLink>; Department of Medicine, Division of Nephrology, Institute for Stem Cells and Regenerative Medicine, and Kidney Research Institute, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Dekel+B%22">Dekel B</searchLink>; The Pediatric Stem Cell Research Institute and Pediatric Nephrology Division, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel HaShomer, Israel. binyamin.dekel@sheba.health.gov.il.; Gray Faculty of Medical & Health Sciences, Tel Aviv University, Ramat Aviv, Tel Aviv, 69978, Israel. binyamin.dekel@sheba.health.gov.il.; Sagol Center for Regenerative Medicine (SCRM), Tel Aviv University, Ramat Aviv, Tel Aviv, Israel. binyamin.dekel@sheba.health.gov.il.
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