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Long-Term Cardiovascular Safety of Testosterone-Replacement Therapy in Middle-Aged and Older Men: A Meta-analysis of Randomized Controlled Trials.

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Title: Long-Term Cardiovascular Safety of Testosterone-Replacement Therapy in Middle-Aged and Older Men: A Meta-analysis of Randomized Controlled Trials.
Authors: Braga MAP; Department of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. braga.marceloantonio0@gmail.com., Rivera A; Department of Medicine, Nove de Julho University, São Bernardo do Campo, Brazil., Marinheiro G; Department of Medicine, Federal University of Ceará, Sobral, Brazil., Felix N; Department of Medicine, Federal University of Campina Grande, Campina Grande, Brazil., Carvalho PEP; Center for Coronary Artery Disease, Minneapolis Heart Institute Foundation, Minneapolis, USA., Gewehr DM; Curitiba Heart Institute, Curitiba, Brazil., Teixeira L; Department of Medicine, Federal University of Campina Grande, Campina Grande, Brazil., Clemente MRC; Department of Medicine, Petrópolis School of Medicine, Petrópolis, Brazil., Reis PCA; Department of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., de Amorim LGCR; Department of Medicine, Federal University of Minas Gerais, Minas Gerais, Brazil., Marinho AD; Department of Medicine, Federal University of the State of Rio de Janeiro, Rio de Janeiro, Brazil., Mendes TB; Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Mesquita FC; Department of Urology, São José do Rio Preto School of Medicine, São Paulo, Brazil., Pozzi E; Desai Sethi Urology Institute, University of Miami Miller School of Medicine, Miami, USA.; Division of Urology, University Vita-Salute San Raffaele, Milan, Italy., Ramasamy R; Jumeirah American Clinic, Dubai, UAE.
Source: American journal of cardiovascular drugs : drugs, devices, and other interventions [Am J Cardiovasc Drugs] 2025 Nov; Vol. 25 (6), pp. 767-777. Date of Electronic Publication: 2025 Jul 22.
Publication Type: Journal Article; Meta-Analysis; Systematic Review
Journal Info: Publisher: Adis, Springer International Country of Publication: New Zealand NLM ID: 100967755 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1179-187X (Electronic) Linking ISSN: 11753277 NLM ISO Abbreviation: Am J Cardiovasc Drugs Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Braga+MAP%22">Braga MAP</searchLink>; Department of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. braga.marceloantonio0@gmail.com.<br /><searchLink fieldCode="AU" term="%22Rivera+A%22">Rivera A</searchLink>; Department of Medicine, Nove de Julho University, São Bernardo do Campo, Brazil.<br /><searchLink fieldCode="AU" term="%22Marinheiro+G%22">Marinheiro G</searchLink>; Department of Medicine, Federal University of Ceará, Sobral, Brazil.<br /><searchLink fieldCode="AU" term="%22Felix+N%22">Felix N</searchLink>; Department of Medicine, Federal University of Campina Grande, Campina Grande, Brazil.<br /><searchLink fieldCode="AU" term="%22Carvalho+PEP%22">Carvalho PEP</searchLink>; Center for Coronary Artery Disease, Minneapolis Heart Institute Foundation, Minneapolis, USA.<br /><searchLink fieldCode="AU" term="%22Gewehr+DM%22">Gewehr DM</searchLink>; Curitiba Heart Institute, Curitiba, Brazil.<br /><searchLink fieldCode="AU" term="%22Teixeira+L%22">Teixeira L</searchLink>; Department of Medicine, Federal University of Campina Grande, Campina Grande, Brazil.<br /><searchLink fieldCode="AU" term="%22Clemente+MRC%22">Clemente MRC</searchLink>; Department of Medicine, Petrópolis School of Medicine, Petrópolis, Brazil.<br /><searchLink fieldCode="AU" term="%22Reis+PCA%22">Reis PCA</searchLink>; Department of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Amorim+LGCR%22">de Amorim LGCR</searchLink>; Department of Medicine, Federal University of Minas Gerais, Minas Gerais, Brazil.<br /><searchLink fieldCode="AU" term="%22Marinho+AD%22">Marinho AD</searchLink>; Department of Medicine, Federal University of the State of Rio de Janeiro, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Mendes+TB%22">Mendes TB</searchLink>; Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Mesquita+FC%22">Mesquita FC</searchLink>; Department of Urology, São José do Rio Preto School of Medicine, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Pozzi+E%22">Pozzi E</searchLink>; Desai Sethi Urology Institute, University of Miami Miller School of Medicine, Miami, USA.; Division of Urology, University Vita-Salute San Raffaele, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Ramasamy+R%22">Ramasamy R</searchLink>; Jumeirah American Clinic, Dubai, UAE.
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