Central memory T cells with key TCR repertoires and gene expression profiles dominate influenza CD8+ T cell pools across the human lifespan.

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Title: Central memory T cells with key TCR repertoires and gene expression profiles dominate influenza CD8+ T cell pools across the human lifespan.
Authors: Menon T; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute, Parkville, VIC 3000, Australia., McQuilten HA; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute, Parkville, VIC 3000, Australia., Samir J; School of Biomedical Sciences, University of New South Wales, Sydney, NSW 2052, Australia., Nguyen THO; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute, Parkville, VIC 3000, Australia., Lim R; Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, VIC 3000, Australia., Kaur J; School of Health Sciences and School of Medicine, University of Tasmania, Launceston, TAS 7248, Australia., Rizzetto S; School of Biomedical Sciences, University of New South Wales, Sydney, NSW 2052, Australia., Eltahla A; School of Biomedical Sciences, University of New South Wales, Sydney, NSW 2052, Australia., Thomas PG; Department of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN 38105., Lappas M; Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, VIC 3000, Australia., Rossjohn J; Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.; Institute of Infection and Immunity, Cardiff University School of Medicine, Cardiff CF14 4XN, United Kingdom., Gras S; Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.; Viral and Structural Immunology Laboratory, Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, VIC 3083, Australia., Crowe J; Deepdene Surgery, Deepdene, VIC 3103, Australia., Flanagan KL; School of Health Sciences and School of Medicine, University of Tasmania, Launceston, TAS 7248, Australia.; School of Health and Biomedical Science, Royal Melbourne Institute of Technology, Melbourne, VIC 3000, Australia.; Tasmanian Vaccine Trial Centre, Clifford Craig Foundation, Launceston General Hospital, Launceston, TAS 7248, Australia., Luciani F; School of Biomedical Sciences, University of New South Wales, Sydney, NSW 2052, Australia., Doherty PC; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute, Parkville, VIC 3000, Australia., van de Sandt CE; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute, Parkville, VIC 3000, Australia., Kedzierska K; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute, Parkville, VIC 3000, Australia.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 Jul 29; Vol. 122 (30), pp. e2501167122. Date of Electronic Publication: 2025 Jul 22.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1091-6490
DOI:10.1073/pnas.2501167122