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Central memory T cells with key TCR repertoires and gene expression profiles dominate influenza CD8+ T cell pools across the human lifespan.

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Title: Central memory T cells with key TCR repertoires and gene expression profiles dominate influenza CD8+ T cell pools across the human lifespan.
Authors: Menon T; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute, Parkville, VIC 3000, Australia., McQuilten HA; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute, Parkville, VIC 3000, Australia., Samir J; School of Biomedical Sciences, University of New South Wales, Sydney, NSW 2052, Australia., Nguyen THO; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute, Parkville, VIC 3000, Australia., Lim R; Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, VIC 3000, Australia., Kaur J; School of Health Sciences and School of Medicine, University of Tasmania, Launceston, TAS 7248, Australia., Rizzetto S; School of Biomedical Sciences, University of New South Wales, Sydney, NSW 2052, Australia., Eltahla A; School of Biomedical Sciences, University of New South Wales, Sydney, NSW 2052, Australia., Thomas PG; Department of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN 38105., Lappas M; Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, VIC 3000, Australia., Rossjohn J; Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.; Institute of Infection and Immunity, Cardiff University School of Medicine, Cardiff CF14 4XN, United Kingdom., Gras S; Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.; Viral and Structural Immunology Laboratory, Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, VIC 3083, Australia., Crowe J; Deepdene Surgery, Deepdene, VIC 3103, Australia., Flanagan KL; School of Health Sciences and School of Medicine, University of Tasmania, Launceston, TAS 7248, Australia.; School of Health and Biomedical Science, Royal Melbourne Institute of Technology, Melbourne, VIC 3000, Australia.; Tasmanian Vaccine Trial Centre, Clifford Craig Foundation, Launceston General Hospital, Launceston, TAS 7248, Australia., Luciani F; School of Biomedical Sciences, University of New South Wales, Sydney, NSW 2052, Australia., Doherty PC; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute, Parkville, VIC 3000, Australia., van de Sandt CE; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute, Parkville, VIC 3000, Australia., Kedzierska K; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute, Parkville, VIC 3000, Australia.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 Jul 29; Vol. 122 (30), pp. e2501167122. Date of Electronic Publication: 2025 Jul 22.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Central memory T cells with key TCR repertoires and gene expression profiles dominate influenza CD8+ T cell pools across the human lifespan.
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  Data: <searchLink fieldCode="AU" term="%22Menon+T%22">Menon T</searchLink>; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute, Parkville, VIC 3000, Australia.<br /><searchLink fieldCode="AU" term="%22McQuilten+HA%22">McQuilten HA</searchLink>; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute, Parkville, VIC 3000, Australia.<br /><searchLink fieldCode="AU" term="%22Samir+J%22">Samir J</searchLink>; School of Biomedical Sciences, University of New South Wales, Sydney, NSW 2052, Australia.<br /><searchLink fieldCode="AU" term="%22Nguyen+THO%22">Nguyen THO</searchLink>; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute, Parkville, VIC 3000, Australia.<br /><searchLink fieldCode="AU" term="%22Lim+R%22">Lim R</searchLink>; Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, VIC 3000, Australia.<br /><searchLink fieldCode="AU" term="%22Kaur+J%22">Kaur J</searchLink>; School of Health Sciences and School of Medicine, University of Tasmania, Launceston, TAS 7248, Australia.<br /><searchLink fieldCode="AU" term="%22Rizzetto+S%22">Rizzetto S</searchLink>; School of Biomedical Sciences, University of New South Wales, Sydney, NSW 2052, Australia.<br /><searchLink fieldCode="AU" term="%22Eltahla+A%22">Eltahla A</searchLink>; School of Biomedical Sciences, University of New South Wales, Sydney, NSW 2052, Australia.<br /><searchLink fieldCode="AU" term="%22Thomas+PG%22">Thomas PG</searchLink>; Department of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN 38105.<br /><searchLink fieldCode="AU" term="%22Lappas+M%22">Lappas M</searchLink>; Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, VIC 3000, Australia.<br /><searchLink fieldCode="AU" term="%22Rossjohn+J%22">Rossjohn J</searchLink>; Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.; Institute of Infection and Immunity, Cardiff University School of Medicine, Cardiff CF14 4XN, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Gras+S%22">Gras S</searchLink>; Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.; Viral and Structural Immunology Laboratory, Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, VIC 3083, Australia.<br /><searchLink fieldCode="AU" term="%22Crowe+J%22">Crowe J</searchLink>; Deepdene Surgery, Deepdene, VIC 3103, Australia.<br /><searchLink fieldCode="AU" term="%22Flanagan+KL%22">Flanagan KL</searchLink>; School of Health Sciences and School of Medicine, University of Tasmania, Launceston, TAS 7248, Australia.; School of Health and Biomedical Science, Royal Melbourne Institute of Technology, Melbourne, VIC 3000, Australia.; Tasmanian Vaccine Trial Centre, Clifford Craig Foundation, Launceston General Hospital, Launceston, TAS 7248, Australia.<br /><searchLink fieldCode="AU" term="%22Luciani+F%22">Luciani F</searchLink>; School of Biomedical Sciences, University of New South Wales, Sydney, NSW 2052, Australia.<br /><searchLink fieldCode="AU" term="%22Doherty+PC%22">Doherty PC</searchLink>; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute, Parkville, VIC 3000, Australia.<br /><searchLink fieldCode="AU" term="%22van+de+Sandt+CE%22">van de Sandt CE</searchLink>; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute, Parkville, VIC 3000, Australia.<br /><searchLink fieldCode="AU" term="%22Kedzierska+K%22">Kedzierska K</searchLink>; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute, Parkville, VIC 3000, Australia.
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  Data: <searchLink fieldCode="JN" term="%227505876%22">Proceedings of the National Academy of Sciences of the United States of America</searchLink> [Proc Natl Acad Sci U S A] 2025 Jul 29; Vol. 122 (30), pp. e2501167122. <i>Date of Electronic Publication: </i>2025 Jul 22.
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