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CAR-engineered lymphocyte persistence is governed by a FAS ligand-FAS autoregulatory circuit.

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Title: CAR-engineered lymphocyte persistence is governed by a FAS ligand-FAS autoregulatory circuit.
Authors: Yi F; Immuno-Oncology Program, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY, USA., Cohen T; Immuno-Oncology Program, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY, USA.; Department of Pediatric Hematology/Oncology, Weill Cornell Medical College, New York, NY, USA., Zimmerman N; Immuno-Oncology Program, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY, USA., Dündar F; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.; Applied Bioinformatics Core, Weill Cornell Medicine, New York, NY, USA.; Catenion, Berlin, Germany., Zumbo P; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.; Applied Bioinformatics Core, Weill Cornell Medicine, New York, NY, USA., Eltilib R; Immuno-Oncology Program, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY, USA., Brophy EJ; Immuno-Oncology Program, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY, USA., Arkin H; Immuno-Oncology Program, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY, USA., Feucht J; Center for Cell Engineering, MSKCC, New York, NY, USA.; Cluster of Excellence iFIT, University Children's Hospital Tübingen, Tübingen, Germany., Gormally MV; Immuno-Oncology Program, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY, USA.; Cell Therapy Service, Department of Medicine, MSKCC, New York, NY, USA., Hackett CS; Department of Medicine, Weill Cornell Medicine, New York, NY, USA., Kropp KN; Immuno-Oncology Program, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY, USA., Etxeberria I; Immuno-Oncology Program, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY, USA., Chandran SS; Immuno-Oncology Program, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY, USA., Zhao Z; Center for Cell Engineering, MSKCC, New York, NY, USA.; Columbia Initiative in Cell Engineering and Therapy, Columbia University, New York, NY, USA., Cai W; Molecular Pharmacology Program, MSKCC, New York, NY, USA., Daniyan AF; Cell Therapy Service, Department of Medicine, MSKCC, New York, NY, USA.; Department of Medicine, Weill Cornell Medicine, New York, NY, USA.; Leukemia Service, Department of Medicine, MSKCC, New York, NY, USA., Park JH; Center for Cell Engineering, MSKCC, New York, NY, USA.; Cell Therapy Service, Department of Medicine, MSKCC, New York, NY, USA.; Department of Medicine, Weill Cornell Medicine, New York, NY, USA.; Leukemia Service, Department of Medicine, MSKCC, New York, NY, USA., Lareau CA; Computational and Systems Biology Program, MSKCC, New York, NY, USA., Hsu KC; Immuno-Oncology Program, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY, USA.; Center for Cell Engineering, MSKCC, New York, NY, USA.; Department of Medicine, Weill Cornell Medicine, New York, NY, USA.; Adult Bone Marrow Transplantation Service, MSKCC, New York, NY, USA.; Immunology Program, Sloan Kettering Institute, MSKCC, New York, NY, USA., Sadelain M; Center for Cell Engineering, MSKCC, New York, NY, USA.; Columbia Initiative in Cell Engineering and Therapy, Columbia University, New York, NY, USA., Betel D; Applied Bioinformatics Core, Weill Cornell Medicine, New York, NY, USA.; Department of Medicine, Weill Cornell Medicine, New York, NY, USA.; Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA., Klebanoff CA; Immuno-Oncology Program, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY, USA. klebanoc@mskcc.org.; Center for Cell Engineering, MSKCC, New York, NY, USA. klebanoc@mskcc.org.; Cell Therapy Service, Department of Medicine, MSKCC, New York, NY, USA. klebanoc@mskcc.org.; Department of Medicine, Weill Cornell Medicine, New York, NY, USA. klebanoc@mskcc.org.; Parker Institute for Cancer Immunotherapy, New York, NY, USA. klebanoc@mskcc.org.
Source: Nature cancer [Nat Cancer] 2025 Oct; Vol. 6 (10), pp. 1638-1655. Date of Electronic Publication: 2025 Jul 22.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101761119 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2662-1347 (Electronic) Linking ISSN: 26621347 NLM ISO Abbreviation: Nat Cancer Subsets: MEDLINE
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  Data: CAR-engineered lymphocyte persistence is governed by a FAS ligand-FAS autoregulatory circuit.
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  Data: <searchLink fieldCode="AU" term="%22Yi+F%22">Yi F</searchLink>; Immuno-Oncology Program, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Cohen+T%22">Cohen T</searchLink>; Immuno-Oncology Program, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY, USA.; Department of Pediatric Hematology/Oncology, Weill Cornell Medical College, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Zimmerman+N%22">Zimmerman N</searchLink>; Immuno-Oncology Program, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Dündar+F%22">Dündar F</searchLink>; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.; Applied Bioinformatics Core, Weill Cornell Medicine, New York, NY, USA.; Catenion, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Zumbo+P%22">Zumbo P</searchLink>; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.; Applied Bioinformatics Core, Weill Cornell Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Eltilib+R%22">Eltilib R</searchLink>; Immuno-Oncology Program, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Brophy+EJ%22">Brophy EJ</searchLink>; Immuno-Oncology Program, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Arkin+H%22">Arkin H</searchLink>; Immuno-Oncology Program, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Feucht+J%22">Feucht J</searchLink>; Center for Cell Engineering, MSKCC, New York, NY, USA.; Cluster of Excellence iFIT, University Children's Hospital Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Gormally+MV%22">Gormally MV</searchLink>; Immuno-Oncology Program, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY, USA.; Cell Therapy Service, Department of Medicine, MSKCC, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Hackett+CS%22">Hackett CS</searchLink>; Department of Medicine, Weill Cornell Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Kropp+KN%22">Kropp KN</searchLink>; Immuno-Oncology Program, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Etxeberria+I%22">Etxeberria I</searchLink>; Immuno-Oncology Program, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Chandran+SS%22">Chandran SS</searchLink>; Immuno-Oncology Program, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Zhao+Z%22">Zhao Z</searchLink>; Center for Cell Engineering, MSKCC, New York, NY, USA.; Columbia Initiative in Cell Engineering and Therapy, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Cai+W%22">Cai W</searchLink>; Molecular Pharmacology Program, MSKCC, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Daniyan+AF%22">Daniyan AF</searchLink>; Cell Therapy Service, Department of Medicine, MSKCC, New York, NY, USA.; Department of Medicine, Weill Cornell Medicine, New York, NY, USA.; Leukemia Service, Department of Medicine, MSKCC, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Park+JH%22">Park JH</searchLink>; Center for Cell Engineering, MSKCC, New York, NY, USA.; Cell Therapy Service, Department of Medicine, MSKCC, New York, NY, USA.; Department of Medicine, Weill Cornell Medicine, New York, NY, USA.; Leukemia Service, Department of Medicine, MSKCC, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Lareau+CA%22">Lareau CA</searchLink>; Computational and Systems Biology Program, MSKCC, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Hsu+KC%22">Hsu KC</searchLink>; Immuno-Oncology Program, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY, USA.; Center for Cell Engineering, MSKCC, New York, NY, USA.; Department of Medicine, Weill Cornell Medicine, New York, NY, USA.; Adult Bone Marrow Transplantation Service, MSKCC, New York, NY, USA.; Immunology Program, Sloan Kettering Institute, MSKCC, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Sadelain+M%22">Sadelain M</searchLink>; Center for Cell Engineering, MSKCC, New York, NY, USA.; Columbia Initiative in Cell Engineering and Therapy, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Betel+D%22">Betel D</searchLink>; Applied Bioinformatics Core, Weill Cornell Medicine, New York, NY, USA.; Department of Medicine, Weill Cornell Medicine, New York, NY, USA.; Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Klebanoff+CA%22">Klebanoff CA</searchLink>; Immuno-Oncology Program, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY, USA. klebanoc@mskcc.org.; Center for Cell Engineering, MSKCC, New York, NY, USA. klebanoc@mskcc.org.; Cell Therapy Service, Department of Medicine, MSKCC, New York, NY, USA. klebanoc@mskcc.org.; Department of Medicine, Weill Cornell Medicine, New York, NY, USA. klebanoc@mskcc.org.; Parker Institute for Cancer Immunotherapy, New York, NY, USA. klebanoc@mskcc.org.
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  Data: <searchLink fieldCode="JN" term="%22101761119%22">Nature cancer</searchLink> [Nat Cancer] 2025 Oct; Vol. 6 (10), pp. 1638-1655. <i>Date of Electronic Publication: </i>2025 Jul 22.
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