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Personalized tobramycin dosing in children with cystic fibrosis: an AUC24-guided approach.

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Title: Personalized tobramycin dosing in children with cystic fibrosis: an AUC24-guided approach.
Authors: Harwood KH; Department of Paediatrics, The University of Melbourne, , Parkville, Victoria, Australia.; Antimicrobials Group, Murdoch Children's Research Institute, Parkville, Victoria, Australia., Duffull S; Certara, Princeton, New Jersey, USA., Shanthikumar S; Department of Paediatrics, The University of Melbourne, , Parkville, Victoria, Australia.; Department of Respiratory and Sleep Medicine, Royal Children's Hospital, Parkville, Victoria, Australia.; Respiratory Diseases Group, Murdoch Children's Research Institute, Parkville, Victoria, Australia., Lei A; Antimicrobials Group, Murdoch Children's Research Institute, Parkville, Victoria, Australia., Ranganathan S; Department of Paediatrics, The University of Melbourne, , Parkville, Victoria, Australia.; Department of Respiratory and Sleep Medicine, Royal Children's Hospital, Parkville, Victoria, Australia.; Respiratory Diseases Group, Murdoch Children's Research Institute, Parkville, Victoria, Australia., Robinson P; Department of Paediatrics, The University of Melbourne, , Parkville, Victoria, Australia.; Department of Respiratory and Sleep Medicine, Royal Children's Hospital, Parkville, Victoria, Australia.; Respiratory Diseases Group, Murdoch Children's Research Institute, Parkville, Victoria, Australia., Sandaradura I; The Children's Hospital at Westmead, Sydney, New South Wales, Australia.; University of Sydney, Sydney, New South Wales, Australia., Lai T; The Children's Hospital at Westmead, Sydney, New South Wales, Australia.; University of Sydney, Sydney, New South Wales, Australia., Gwee A; Department of Paediatrics, The University of Melbourne, , Parkville, Victoria, Australia.; Antimicrobials Group, Murdoch Children's Research Institute, Parkville, Victoria, Australia.; Department of General Medicine, Royal Children's Hospital, Parkville, Victoria, Australia.
Source: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2025 Sep 03; Vol. 69 (9), pp. e0027825. Date of Electronic Publication: 2025 Jul 23.
Publication Type: Journal Article; Observational Study; Multicenter Study
Journal Info: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 0315061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-6596 (Electronic) Linking ISSN: 00664804 NLM ISO Abbreviation: Antimicrob Agents Chemother Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Personalized tobramycin dosing in children with cystic fibrosis: an AUC<subscript>24</subscript>-guided approach.
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  Data: <searchLink fieldCode="AU" term="%22Harwood+KH%22">Harwood KH</searchLink>; Department of Paediatrics, The University of Melbourne, , Parkville, Victoria, Australia.; Antimicrobials Group, Murdoch Children's Research Institute, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Duffull+S%22">Duffull S</searchLink>; Certara, Princeton, New Jersey, USA.<br /><searchLink fieldCode="AU" term="%22Shanthikumar+S%22">Shanthikumar S</searchLink>; Department of Paediatrics, The University of Melbourne, , Parkville, Victoria, Australia.; Department of Respiratory and Sleep Medicine, Royal Children's Hospital, Parkville, Victoria, Australia.; Respiratory Diseases Group, Murdoch Children's Research Institute, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Lei+A%22">Lei A</searchLink>; Antimicrobials Group, Murdoch Children's Research Institute, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Ranganathan+S%22">Ranganathan S</searchLink>; Department of Paediatrics, The University of Melbourne, , Parkville, Victoria, Australia.; Department of Respiratory and Sleep Medicine, Royal Children's Hospital, Parkville, Victoria, Australia.; Respiratory Diseases Group, Murdoch Children's Research Institute, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Robinson+P%22">Robinson P</searchLink>; Department of Paediatrics, The University of Melbourne, , Parkville, Victoria, Australia.; Department of Respiratory and Sleep Medicine, Royal Children's Hospital, Parkville, Victoria, Australia.; Respiratory Diseases Group, Murdoch Children's Research Institute, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Sandaradura+I%22">Sandaradura I</searchLink>; The Children's Hospital at Westmead, Sydney, New South Wales, Australia.; University of Sydney, Sydney, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Lai+T%22">Lai T</searchLink>; The Children's Hospital at Westmead, Sydney, New South Wales, Australia.; University of Sydney, Sydney, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Gwee+A%22">Gwee A</searchLink>; Department of Paediatrics, The University of Melbourne, , Parkville, Victoria, Australia.; Antimicrobials Group, Murdoch Children's Research Institute, Parkville, Victoria, Australia.; Department of General Medicine, Royal Children's Hospital, Parkville, Victoria, Australia.
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  Data: <searchLink fieldCode="JN" term="%220315061%22">Antimicrobial agents and chemotherapy</searchLink> [Antimicrob Agents Chemother] 2025 Sep 03; Vol. 69 (9), pp. e0027825. <i>Date of Electronic Publication: </i>2025 Jul 23.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Society+for+Microbiology%22">American Society for Microbiology </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0315061 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1098-6596 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200664804%22">00664804 </searchLink><i>NLM ISO Abbreviation: </i>Antimicrob Agents Chemother <i>Subsets: </i>MEDLINE
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        Value: 10.1128/aac.00278-25
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              M: 09
              Text: 2025 Sep 03
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