Synaptic and intrinsic plasticity mediated by CCK-type signaling coordinates behavioral changes during motivational state shifts.

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Title: Synaptic and intrinsic plasticity mediated by CCK-type signaling coordinates behavioral changes during motivational state shifts.
Authors: Zhang G; State Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology and Medical Psychology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Institute for Brain Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China. Electronic address: zhangguonanda@nju.edu.cn., Ding XY; State Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology and Medical Psychology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Institute for Brain Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China., Romanova EV; Department of Chemistry and the Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, USA., Liu CP; State Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology and Medical Psychology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Institute for Brain Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China., Barry MA; Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Doda A; Department of Chemistry, University of Nebraska-Lincoln, Lincoln, NE, USA., Chen QX; Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Reaver C; Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Jin QC; State Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology and Medical Psychology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Institute for Brain Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China., Rubakhin SS; Department of Chemistry and the Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, USA., Li F; State Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology and Medical Psychology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Institute for Brain Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China., Jin YF; State Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology and Medical Psychology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Institute for Brain Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China., Kan YS; State Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology and Medical Psychology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Institute for Brain Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China., Liu YL; State Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology and Medical Psychology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Institute for Brain Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China., Guo SQ; State Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology and Medical Psychology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Institute for Brain Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China., Xue YY; State Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology and Medical Psychology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Institute for Brain Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China., Mei YS; State Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology and Medical Psychology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Institute for Brain Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China., Fu P; State Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology and Medical Psychology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Institute for Brain Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China., Xu JP; State Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology and Medical Psychology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Institute for Brain Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China., Mao RT; State Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology and Medical Psychology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Institute for Brain Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China., Liu CY; State Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology and Medical Psychology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Institute for Brain Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China., Zhang YC; State Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology and Medical Psychology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Institute for Brain Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China., Zhang YL; State Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology and Medical Psychology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Institute for Brain Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China., Chang JH; State Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology and Medical Psychology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Institute for Brain Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China., Wu SQ; State Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology and Medical Psychology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Institute for Brain Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China., Wang HY; State Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology and Medical Psychology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Institute for Brain Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China., Liu WJ; State Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology and Medical Psychology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Institute for Brain Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China., Chen P; State Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology and Medical Psychology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Institute for Brain Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China., Zhou Z; State Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology and Medical Psychology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Institute for Brain Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China., Zhou HB; School of Electronic Science and Engineering, Nanjing University, Nanjing, Jiangsu, China; Peng Cheng Laboratory, Shenzhen, China. Electronic address: haibozhou@nju.edu.cn., Yu Q; Peng Cheng Laboratory, Shenzhen, China. Electronic address: yuq@pcl.ac.cn., Checco JW; Department of Chemistry, University of Nebraska-Lincoln, Lincoln, NE, USA; The Nebraska Center for Integrated Biomolecular Communication (NCIBC), University of Nebraska-Lincoln, Lincoln, NE, USA., Sweedler JV; Department of Chemistry and the Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, USA., Cropper EC; Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Jing J; State Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology and Medical Psychology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Institute for Brain Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China; Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Peng Cheng Laboratory, Shenzhen, China. Electronic address: jingj01@live.com.
Source: Cell reports [Cell Rep] 2025 Aug 26; Vol. 44 (8), pp. 116049. Date of Electronic Publication: 2025 Jul 22.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
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  Data: Synaptic and intrinsic plasticity mediated by CCK-type signaling coordinates behavioral changes during motivational state shifts.
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  Data: <searchLink fieldCode="AU" term="%22Zhang+G%22">Zhang G</searchLink>; State Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology and Medical Psychology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Institute for Brain Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China. Electronic address: zhangguonanda@nju.edu.cn.<br /><searchLink fieldCode="AU" term="%22Ding+XY%22">Ding XY</searchLink>; State Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology and Medical Psychology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Institute for Brain Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China.<br /><searchLink fieldCode="AU" term="%22Romanova+EV%22">Romanova EV</searchLink>; Department of Chemistry and the Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.<br /><searchLink fieldCode="AU" term="%22Liu+CP%22">Liu CP</searchLink>; State Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology and Medical Psychology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Institute for Brain Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China.<br /><searchLink fieldCode="AU" term="%22Barry+MA%22">Barry MA</searchLink>; 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Department of Chemistry and the Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.<br /><searchLink fieldCode="AU" term="%22Li+F%22">Li F</searchLink>; State Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology and Medical Psychology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Institute for Brain Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China.<br /><searchLink fieldCode="AU" term="%22Jin+YF%22">Jin YF</searchLink>; State Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology and Medical Psychology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Institute for Brain Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China.<br /><searchLink fieldCode="AU" term="%22Kan+YS%22">Kan YS</searchLink>; State Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology and Medical Psychology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Institute for Brain Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China.<br /><searchLink fieldCode="AU" term="%22Liu+YL%22">Liu YL</searchLink>; State Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology and Medical Psychology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Institute for Brain Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China.<br /><searchLink fieldCode="AU" term="%22Guo+SQ%22">Guo SQ</searchLink>; State Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology and Medical Psychology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Institute for Brain Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China.<br /><searchLink fieldCode="AU" term="%22Xue+YY%22">Xue YY</searchLink>; State Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology and Medical Psychology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Institute for Brain Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China.<br /><searchLink fieldCode="AU" term="%22Mei+YS%22">Mei YS</searchLink>; State Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology and Medical Psychology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Institute for Brain Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China.<br /><searchLink fieldCode="AU" term="%22Fu+P%22">Fu P</searchLink>; State Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology and Medical Psychology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Institute for Brain Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China.<br /><searchLink fieldCode="AU" term="%22Xu+JP%22">Xu JP</searchLink>; State Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology and Medical Psychology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Institute for Brain Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China.<br /><searchLink fieldCode="AU" term="%22Mao+RT%22">Mao RT</searchLink>; State Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology and Medical Psychology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Institute for Brain Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China.<br /><searchLink fieldCode="AU" term="%22Liu+CY%22">Liu CY</searchLink>; State Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology and Medical Psychology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Institute for Brain Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China.<br /><searchLink fieldCode="AU" term="%22Zhang+YC%22">Zhang YC</searchLink>; State Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology and Medical Psychology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Institute for Brain Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China.<br /><searchLink fieldCode="AU" term="%22Zhang+YL%22">Zhang YL</searchLink>; State Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology and Medical Psychology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Institute for Brain Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China.<br /><searchLink fieldCode="AU" term="%22Chang+JH%22">Chang JH</searchLink>; State Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology and Medical Psychology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Institute for Brain Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China.<br /><searchLink fieldCode="AU" term="%22Wu+SQ%22">Wu SQ</searchLink>; State Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology and Medical Psychology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Institute for Brain Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China.<br /><searchLink fieldCode="AU" term="%22Wang+HY%22">Wang HY</searchLink>; State Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology and Medical Psychology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Institute for Brain Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China.<br /><searchLink fieldCode="AU" term="%22Liu+WJ%22">Liu WJ</searchLink>; State Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology and Medical Psychology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Institute for Brain Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China.<br /><searchLink fieldCode="AU" term="%22Chen+P%22">Chen P</searchLink>; State Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology and Medical Psychology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Institute for Brain Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China.<br /><searchLink fieldCode="AU" term="%22Zhou+Z%22">Zhou Z</searchLink>; State Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology and Medical Psychology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Institute for Brain Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China.<br /><searchLink fieldCode="AU" term="%22Zhou+HB%22">Zhou HB</searchLink>; School of Electronic Science and Engineering, Nanjing University, Nanjing, Jiangsu, China; Peng Cheng Laboratory, Shenzhen, China. Electronic address: haibozhou@nju.edu.cn.<br /><searchLink fieldCode="AU" term="%22Yu+Q%22">Yu Q</searchLink>; Peng Cheng Laboratory, Shenzhen, China. Electronic address: yuq@pcl.ac.cn.<br /><searchLink fieldCode="AU" term="%22Checco+JW%22">Checco JW</searchLink>; Department of Chemistry, University of Nebraska-Lincoln, Lincoln, NE, USA; The Nebraska Center for Integrated Biomolecular Communication (NCIBC), University of Nebraska-Lincoln, Lincoln, NE, USA.<br /><searchLink fieldCode="AU" term="%22Sweedler+JV%22">Sweedler JV</searchLink>; Department of Chemistry and the Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.<br /><searchLink fieldCode="AU" term="%22Cropper+EC%22">Cropper EC</searchLink>; Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Jing+J%22">Jing J</searchLink>; State Key Laboratory of Pharmaceutical Biotechnology, Department of Neurology and Medical Psychology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Institute for Brain Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China; Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Peng Cheng Laboratory, Shenzhen, China. 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