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Early Infliximab Levels and Clearance Predict Outcomes After Infliximab Rescue in Acute Severe Ulcerative Colitis: Results From PREDICT-UC.

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Title: Early Infliximab Levels and Clearance Predict Outcomes After Infliximab Rescue in Acute Severe Ulcerative Colitis: Results From PREDICT-UC.
Authors: Li Wai Suen CFD; Austin Health, Department of Gastroenterology, Melbourne, Australia; St Vincent's Hospital Melbourne, Immunology Research Centre, Melbourne, Australia; University of Melbourne, Department of Medicine (Austin Health), Melbourne, Australia., Choy MC; Austin Health, Department of Gastroenterology, Melbourne, Australia; University of Melbourne, Department of Medicine (Austin Health), Melbourne, Australia., Con D; Austin Health, Department of Gastroenterology, Melbourne, Australia; University of Melbourne, Department of Medicine (Austin Health), Melbourne, Australia., Cheng K; St Vincent's Hospital Melbourne, Immunology Research Centre, Melbourne, Australia., Nigro J; St Vincent's Hospital Melbourne, Immunology Research Centre, Melbourne, Australia., Breheney K; St Vincent's Hospital Melbourne, Immunology Research Centre, Melbourne, Australia., Boyd K; Austin Health, Department of Gastroenterology, Melbourne, Australia., Pena R; Austin Health, Department of Gastroenterology, Melbourne, Australia., Burrell K; Austin Health, Department of Gastroenterology, Melbourne, Australia., Rosella O; Austin Health, Department of Gastroenterology, Melbourne, Australia., Proud D; Austin Health, Department of Colorectal Surgery, Melbourne, Australia., Brouwer R; Austin Health, Department of Colorectal Surgery, Melbourne, Australia., Gorelik A; Monash University, School of Public Health and Preventive Medicine, Melbourne, Australia., Liew D; University of Adelaide, Department of Medicine, Adelaide, Australia., Connell WR; St Vincent's Hospital Melbourne, Department of Gastroenterology, Melbourne, Australia., Wright EK; St Vincent's Hospital Melbourne, Department of Gastroenterology, Melbourne, Australia; University of Melbourne, Department of Medicine (St Vincent's Hospital), Melbourne, Australia., Taylor KM; Alfred Health, Department of Gastroenterology, Melbourne, Australia., Pudipeddi A; Concord Hospital, Department of Gastroenterology, Sydney, Australia., Sawers M; Barwon Health, Department of Gastroenterology, Geelong, Australia., Christensen B; University of Melbourne, Department of Medicine (Royal Melbourne Hospital), Melbourne, Australia., Ng W; Liverpool Hospital, Department of Gastroenterology, Sydney, Australia., Begun J; Mater Hospital, Department of Gastroenterology, Brisbane, Australia., Radford-Smith GL; Royal Brisbane and Women's Hospital, Department of Gastroenterology, Brisbane, Australia; University of Queensland Faculty of Medicine, Brisbane, Australia; QIMR Berghofer Medical Research Institute, Brisbane, Australia., Garg M; Northern Health, Department of Gastroenterology, Melbourne, Australia., Martin N; Princess Alexandra Hospital, Department of Gastroenterology, Brisbane, Australia., van Langenberg DR; Eastern Health, Department of Gastroenterology, Melbourne, Australia., Ding NS; St Vincent's Hospital Melbourne, Department of Gastroenterology, Melbourne, Australia., Beswick L; Barwon Health, Department of Gastroenterology, Geelong, Australia., Leong RW; Concord Hospital, Department of Gastroenterology, Sydney, Australia., Sparrow MP; Alfred Health, Department of Gastroenterology, Melbourne, Australia., Grosserichter-Wagener C; Essange Reagents, Amsterdam, the Netherlands., Te Velthuis H; Essange Reagents, Amsterdam, the Netherlands., Visvanathan K; St Vincent's Hospital Melbourne, Immunology Research Centre, Melbourne, Australia; University of Melbourne, Department of Medicine (St Vincent's Hospital), Melbourne, Australia., De Cruz P; Austin Health, Department of Gastroenterology, Melbourne, Australia; University of Melbourne, Department of Medicine (Austin Health), Melbourne, Australia. Electronic address: ppdecruz@gmail.com.
Source: Gastroenterology [Gastroenterology] 2026 Jan; Vol. 170 (1), pp. 118-131. Date of Electronic Publication: 2025 Jul 21.
Publication Type: Journal Article; Randomized Controlled Trial; Multicenter Study
Journal Info: Publisher: W.B. Saunders Country of Publication: United States NLM ID: 0374630 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-0012 (Electronic) Linking ISSN: 00165085 NLM ISO Abbreviation: Gastroenterology Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Early Infliximab Levels and Clearance Predict Outcomes After Infliximab Rescue in Acute Severe Ulcerative Colitis: Results From PREDICT-UC.
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  Data: <searchLink fieldCode="AU" term="%22Li+Wai+Suen+CFD%22">Li Wai Suen CFD</searchLink>; Austin Health, Department of Gastroenterology, Melbourne, Australia; St Vincent's Hospital Melbourne, Immunology Research Centre, Melbourne, Australia; University of Melbourne, Department of Medicine (Austin Health), Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Choy+MC%22">Choy MC</searchLink>; Austin Health, Department of Gastroenterology, Melbourne, Australia; University of Melbourne, Department of Medicine (Austin Health), Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Con+D%22">Con D</searchLink>; Austin Health, Department of Gastroenterology, Melbourne, Australia; University of Melbourne, Department of Medicine (Austin Health), Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Cheng+K%22">Cheng K</searchLink>; St Vincent's Hospital Melbourne, Immunology Research Centre, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Nigro+J%22">Nigro J</searchLink>; St Vincent's Hospital Melbourne, Immunology Research Centre, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Breheney+K%22">Breheney K</searchLink>; St Vincent's Hospital Melbourne, Immunology Research Centre, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Boyd+K%22">Boyd K</searchLink>; Austin Health, Department of Gastroenterology, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Pena+R%22">Pena R</searchLink>; Austin Health, Department of Gastroenterology, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Burrell+K%22">Burrell K</searchLink>; Austin Health, Department of Gastroenterology, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Rosella+O%22">Rosella O</searchLink>; Austin Health, Department of Gastroenterology, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Proud+D%22">Proud D</searchLink>; Austin Health, Department of Colorectal Surgery, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Brouwer+R%22">Brouwer R</searchLink>; Austin Health, Department of Colorectal Surgery, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Gorelik+A%22">Gorelik A</searchLink>; Monash University, School of Public Health and Preventive Medicine, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Liew+D%22">Liew D</searchLink>; University of Adelaide, Department of Medicine, Adelaide, Australia.<br /><searchLink fieldCode="AU" term="%22Connell+WR%22">Connell WR</searchLink>; St Vincent's Hospital Melbourne, Department of Gastroenterology, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Wright+EK%22">Wright EK</searchLink>; St Vincent's Hospital Melbourne, Department of Gastroenterology, Melbourne, Australia; University of Melbourne, Department of Medicine (St Vincent's Hospital), Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Taylor+KM%22">Taylor KM</searchLink>; Alfred Health, Department of Gastroenterology, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Pudipeddi+A%22">Pudipeddi A</searchLink>; Concord Hospital, Department of Gastroenterology, Sydney, Australia.<br /><searchLink fieldCode="AU" term="%22Sawers+M%22">Sawers M</searchLink>; Barwon Health, Department of Gastroenterology, Geelong, Australia.<br /><searchLink fieldCode="AU" term="%22Christensen+B%22">Christensen B</searchLink>; University of Melbourne, Department of Medicine (Royal Melbourne Hospital), Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Ng+W%22">Ng W</searchLink>; Liverpool Hospital, Department of Gastroenterology, Sydney, Australia.<br /><searchLink fieldCode="AU" term="%22Begun+J%22">Begun J</searchLink>; Mater Hospital, Department of Gastroenterology, Brisbane, Australia.<br /><searchLink fieldCode="AU" term="%22Radford-Smith+GL%22">Radford-Smith GL</searchLink>; Royal Brisbane and Women's Hospital, Department of Gastroenterology, Brisbane, Australia; University of Queensland Faculty of Medicine, Brisbane, Australia; QIMR Berghofer Medical Research Institute, Brisbane, Australia.<br /><searchLink fieldCode="AU" term="%22Garg+M%22">Garg M</searchLink>; Northern Health, Department of Gastroenterology, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Martin+N%22">Martin N</searchLink>; Princess Alexandra Hospital, Department of Gastroenterology, Brisbane, Australia.<br /><searchLink fieldCode="AU" term="%22van+Langenberg+DR%22">van Langenberg DR</searchLink>; Eastern Health, Department of Gastroenterology, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Ding+NS%22">Ding NS</searchLink>; St Vincent's Hospital Melbourne, Department of Gastroenterology, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Beswick+L%22">Beswick L</searchLink>; Barwon Health, Department of Gastroenterology, Geelong, Australia.<br /><searchLink fieldCode="AU" term="%22Leong+RW%22">Leong RW</searchLink>; Concord Hospital, Department of Gastroenterology, Sydney, Australia.<br /><searchLink fieldCode="AU" term="%22Sparrow+MP%22">Sparrow MP</searchLink>; Alfred Health, Department of Gastroenterology, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Grosserichter-Wagener+C%22">Grosserichter-Wagener C</searchLink>; Essange Reagents, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Te+Velthuis+H%22">Te Velthuis H</searchLink>; Essange Reagents, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Visvanathan+K%22">Visvanathan K</searchLink>; St Vincent's Hospital Melbourne, Immunology Research Centre, Melbourne, Australia; University of Melbourne, Department of Medicine (St Vincent's Hospital), Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22De+Cruz+P%22">De Cruz P</searchLink>; Austin Health, Department of Gastroenterology, Melbourne, Australia; University of Melbourne, Department of Medicine (Austin Health), Melbourne, Australia. Electronic address: ppdecruz@gmail.com.
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  Data: <searchLink fieldCode="JN" term="%220374630%22">Gastroenterology</searchLink> [Gastroenterology] 2026 Jan; Vol. 170 (1), pp. 118-131. <i>Date of Electronic Publication: </i>2025 Jul 21.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22W%2EB%2E+Saunders%22">W.B. Saunders </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0374630 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1528-0012 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200165085%22">00165085 </searchLink><i>NLM ISO Abbreviation: </i>Gastroenterology <i>Subsets: </i>MEDLINE
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        Value: 10.1053/j.gastro.2025.07.020
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