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Insulin-like peptide 5 is released in response to bile acid in the rectum and is associated with diarrhoea severity in patients with bile acid diarrhoea.

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Title: Insulin-like peptide 5 is released in response to bile acid in the rectum and is associated with diarrhoea severity in patients with bile acid diarrhoea.
Authors: Bannon CA; Institute of Metabolic Science, Cambridge, UK., Walters JRF; Division of Digestive Diseases, Imperial College London, London, UK.; Imperial College Healthcare Trust, London, UK., Wu T; Adelaide Medical School and Centre of Research Excellence in Translating Nutritional Science to Good Health, The University of Adelaide, Adelaide, South Australia, Australia., Kay RG; Institute of Metabolic Science, Cambridge, UK., Punnoose A; Institute of Metabolic Science, Cambridge, UK., Spiller RC; Nottingham Digestive Diseases Centre, University of Nottingham, Nottingham, UK.; NIHR Nottingham Biomedical Research Centre, Nottingham, UK., Wilson J; Eli Lilly and Company, Indianapolis, Indiana, USA., Verdino P; Eli Lilly and Company, Lilly Biotechnology Center, San Diego, California, USA., Barker P; Institute of Metabolic Science, Cambridge, UK., Burling K; Institute of Metabolic Science, Cambridge, UK., Horowitz M; Adelaide Medical School and Centre of Research Excellence in Translating Nutritional Science to Good Health, The University of Adelaide, Adelaide, South Australia, Australia., Rayner CK; Adelaide Medical School and Centre of Research Excellence in Translating Nutritional Science to Good Health, The University of Adelaide, Adelaide, South Australia, Australia., Ford AC; Leeds Institute of Medical Research at St. James's, University of Leeds, Leeds, UK.; Leeds Gastroenterology Institute, Leeds Teaching Hospitals NHS Trust, Leeds, UK., Reimann F; Institute of Metabolic Science, Cambridge, UK fmg23@cam.ac.uk fr222@cam.ac.uk., Gribble FM; Institute of Metabolic Science, Cambridge, UK fmg23@cam.ac.uk fr222@cam.ac.uk.
Source: Gut [Gut] 2026 Jan 08; Vol. 75 (2), pp. 278-288. Date of Electronic Publication: 2026 Jan 08.
Publication Type: Journal Article
Journal Info: Publisher: British Medical Assn Country of Publication: England NLM ID: 2985108R Publication Model: Electronic Cited Medium: Internet ISSN: 1468-3288 (Electronic) Linking ISSN: 00175749 NLM ISO Abbreviation: Gut Subsets: MEDLINE
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  Data: Insulin-like peptide 5 is released in response to bile acid in the rectum and is associated with diarrhoea severity in patients with bile acid diarrhoea.
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  Data: <searchLink fieldCode="AU" term="%22Bannon+CA%22">Bannon CA</searchLink>; Institute of Metabolic Science, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Walters+JRF%22">Walters JRF</searchLink>; Division of Digestive Diseases, Imperial College London, London, UK.; Imperial College Healthcare Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Wu+T%22">Wu T</searchLink>; Adelaide Medical School and Centre of Research Excellence in Translating Nutritional Science to Good Health, The University of Adelaide, Adelaide, South Australia, Australia.<br /><searchLink fieldCode="AU" term="%22Kay+RG%22">Kay RG</searchLink>; Institute of Metabolic Science, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Punnoose+A%22">Punnoose A</searchLink>; Institute of Metabolic Science, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Spiller+RC%22">Spiller RC</searchLink>; Nottingham Digestive Diseases Centre, University of Nottingham, Nottingham, UK.; NIHR Nottingham Biomedical Research Centre, Nottingham, UK.<br /><searchLink fieldCode="AU" term="%22Wilson+J%22">Wilson J</searchLink>; Eli Lilly and Company, Indianapolis, Indiana, USA.<br /><searchLink fieldCode="AU" term="%22Verdino+P%22">Verdino P</searchLink>; Eli Lilly and Company, Lilly Biotechnology Center, San Diego, California, USA.<br /><searchLink fieldCode="AU" term="%22Barker+P%22">Barker P</searchLink>; Institute of Metabolic Science, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Burling+K%22">Burling K</searchLink>; Institute of Metabolic Science, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Horowitz+M%22">Horowitz M</searchLink>; Adelaide Medical School and Centre of Research Excellence in Translating Nutritional Science to Good Health, The University of Adelaide, Adelaide, South Australia, Australia.<br /><searchLink fieldCode="AU" term="%22Rayner+CK%22">Rayner CK</searchLink>; Adelaide Medical School and Centre of Research Excellence in Translating Nutritional Science to Good Health, The University of Adelaide, Adelaide, South Australia, Australia.<br /><searchLink fieldCode="AU" term="%22Ford+AC%22">Ford AC</searchLink>; Leeds Institute of Medical Research at St. James's, University of Leeds, Leeds, UK.; Leeds Gastroenterology Institute, Leeds Teaching Hospitals NHS Trust, Leeds, UK.<br /><searchLink fieldCode="AU" term="%22Reimann+F%22">Reimann F</searchLink>; Institute of Metabolic Science, Cambridge, UK fmg23@cam.ac.uk fr222@cam.ac.uk.<br /><searchLink fieldCode="AU" term="%22Gribble+FM%22">Gribble FM</searchLink>; Institute of Metabolic Science, Cambridge, UK fmg23@cam.ac.uk fr222@cam.ac.uk.
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  Data: <searchLink fieldCode="JN" term="%222985108R%22">Gut</searchLink> [Gut] 2026 Jan 08; Vol. 75 (2), pp. 278-288. <i>Date of Electronic Publication: </i>2026 Jan 08.
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        Value: 10.1136/gutjnl-2025-335393
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              Text: 2026 Jan 08
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