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Crystallizing the Uncrystallizable: Insights from Extensive Screening of PROTACs.

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Title: Crystallizing the Uncrystallizable: Insights from Extensive Screening of PROTACs.
Authors: Screen MA; Department of Chemistry, Durham University, South Road, Durham DH1 3LE, U.K., McCabe JF; Early Pharmaceutical Development & Manufacture, Pharmaceutical Sciences, R&D, AstraZeneca, Macclesfield SK10 2NA, U.K., Askin S; Advanced Drug Delivery, Pharmaceutical Sciences, R&D, AstraZeneca, Cambridge CB2 0AA, U.K., Guest JL; Department of Chemistry, Durham University, South Road, Durham DH1 3LE, U.K., Hodgkinson P; Department of Chemistry, Durham University, South Road, Durham DH1 3LE, U.K., Cruz-Cabeza AJ; Department of Chemistry, Durham University, South Road, Durham DH1 3LE, U.K., Blundell TJ; Department of Chemistry, Durham University, South Road, Durham DH1 3LE, U.K., Rainer DN; School of Chemistry and Chemical Engineering, University of Southampton, Highfield Campus, Southampton SO17 1BJ, U.K., Coles SJ; School of Chemistry and Chemical Engineering, University of Southampton, Highfield Campus, Southampton SO17 1BJ, U.K., Longcake A; School of Natural and Environmental Sciences, Bedson Building, Newcastle University, Kings Road, Newcastle upon Tyne NE1 7RU, U.K., Probert MR; School of Natural and Environmental Sciences, Bedson Building, Newcastle University, Kings Road, Newcastle upon Tyne NE1 7RU, U.K., Mahon CS; Department of Chemistry, Durham University, South Road, Durham DH1 3LE, U.K., Wilson MR; Department of Chemistry, Durham University, South Road, Durham DH1 3LE, U.K., Steed JW; Department of Chemistry, Durham University, South Road, Durham DH1 3LE, U.K.
Source: Journal of the American Chemical Society [J Am Chem Soc] 2025 Aug 06; Vol. 147 (31), pp. 28056-28072. Date of Electronic Publication: 2025 Jul 23.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 7503056 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5126 (Electronic) Linking ISSN: 00027863 NLM ISO Abbreviation: J Am Chem Soc Subsets: MEDLINE; PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Crystallizing the Uncrystallizable: Insights from Extensive Screening of PROTACs.
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  Data: <searchLink fieldCode="AU" term="%22Screen+MA%22">Screen MA</searchLink>; Department of Chemistry, Durham University, South Road, Durham DH1 3LE, U.K.<br /><searchLink fieldCode="AU" term="%22McCabe+JF%22">McCabe JF</searchLink>; Early Pharmaceutical Development & Manufacture, Pharmaceutical Sciences, R&D, AstraZeneca, Macclesfield SK10 2NA, U.K.<br /><searchLink fieldCode="AU" term="%22Askin+S%22">Askin S</searchLink>; Advanced Drug Delivery, Pharmaceutical Sciences, R&D, AstraZeneca, Cambridge CB2 0AA, U.K.<br /><searchLink fieldCode="AU" term="%22Guest+JL%22">Guest JL</searchLink>; Department of Chemistry, Durham University, South Road, Durham DH1 3LE, U.K.<br /><searchLink fieldCode="AU" term="%22Hodgkinson+P%22">Hodgkinson P</searchLink>; Department of Chemistry, Durham University, South Road, Durham DH1 3LE, U.K.<br /><searchLink fieldCode="AU" term="%22Cruz-Cabeza+AJ%22">Cruz-Cabeza AJ</searchLink>; Department of Chemistry, Durham University, South Road, Durham DH1 3LE, U.K.<br /><searchLink fieldCode="AU" term="%22Blundell+TJ%22">Blundell TJ</searchLink>; Department of Chemistry, Durham University, South Road, Durham DH1 3LE, U.K.<br /><searchLink fieldCode="AU" term="%22Rainer+DN%22">Rainer DN</searchLink>; School of Chemistry and Chemical Engineering, University of Southampton, Highfield Campus, Southampton SO17 1BJ, U.K.<br /><searchLink fieldCode="AU" term="%22Coles+SJ%22">Coles SJ</searchLink>; School of Chemistry and Chemical Engineering, University of Southampton, Highfield Campus, Southampton SO17 1BJ, U.K.<br /><searchLink fieldCode="AU" term="%22Longcake+A%22">Longcake A</searchLink>; School of Natural and Environmental Sciences, Bedson Building, Newcastle University, Kings Road, Newcastle upon Tyne NE1 7RU, U.K.<br /><searchLink fieldCode="AU" term="%22Probert+MR%22">Probert MR</searchLink>; School of Natural and Environmental Sciences, Bedson Building, Newcastle University, Kings Road, Newcastle upon Tyne NE1 7RU, U.K.<br /><searchLink fieldCode="AU" term="%22Mahon+CS%22">Mahon CS</searchLink>; Department of Chemistry, Durham University, South Road, Durham DH1 3LE, U.K.<br /><searchLink fieldCode="AU" term="%22Wilson+MR%22">Wilson MR</searchLink>; Department of Chemistry, Durham University, South Road, Durham DH1 3LE, U.K.<br /><searchLink fieldCode="AU" term="%22Steed+JW%22">Steed JW</searchLink>; Department of Chemistry, Durham University, South Road, Durham DH1 3LE, U.K.
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  Data: <searchLink fieldCode="JN" term="%227503056%22">Journal of the American Chemical Society</searchLink> [J Am Chem Soc] 2025 Aug 06; Vol. 147 (31), pp. 28056-28072. <i>Date of Electronic Publication: </i>2025 Jul 23.
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