Crystallizing the Uncrystallizable: Insights from Extensive Screening of PROTACs.

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Bibliographic Details
Title: Crystallizing the Uncrystallizable: Insights from Extensive Screening of PROTACs.
Authors: Screen MA; Department of Chemistry, Durham University, South Road, Durham DH1 3LE, U.K., McCabe JF; Early Pharmaceutical Development & Manufacture, Pharmaceutical Sciences, R&D, AstraZeneca, Macclesfield SK10 2NA, U.K., Askin S; Advanced Drug Delivery, Pharmaceutical Sciences, R&D, AstraZeneca, Cambridge CB2 0AA, U.K., Guest JL; Department of Chemistry, Durham University, South Road, Durham DH1 3LE, U.K., Hodgkinson P; Department of Chemistry, Durham University, South Road, Durham DH1 3LE, U.K., Cruz-Cabeza AJ; Department of Chemistry, Durham University, South Road, Durham DH1 3LE, U.K., Blundell TJ; Department of Chemistry, Durham University, South Road, Durham DH1 3LE, U.K., Rainer DN; School of Chemistry and Chemical Engineering, University of Southampton, Highfield Campus, Southampton SO17 1BJ, U.K., Coles SJ; School of Chemistry and Chemical Engineering, University of Southampton, Highfield Campus, Southampton SO17 1BJ, U.K., Longcake A; School of Natural and Environmental Sciences, Bedson Building, Newcastle University, Kings Road, Newcastle upon Tyne NE1 7RU, U.K., Probert MR; School of Natural and Environmental Sciences, Bedson Building, Newcastle University, Kings Road, Newcastle upon Tyne NE1 7RU, U.K., Mahon CS; Department of Chemistry, Durham University, South Road, Durham DH1 3LE, U.K., Wilson MR; Department of Chemistry, Durham University, South Road, Durham DH1 3LE, U.K., Steed JW; Department of Chemistry, Durham University, South Road, Durham DH1 3LE, U.K.
Source: Journal of the American Chemical Society [J Am Chem Soc] 2025 Aug 06; Vol. 147 (31), pp. 28056-28072. Date of Electronic Publication: 2025 Jul 23.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 7503056 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5126 (Electronic) Linking ISSN: 00027863 NLM ISO Abbreviation: J Am Chem Soc Subsets: MEDLINE; PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1520-5126
DOI:10.1021/jacs.5c07977