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Inhibitor Affinity Differs among Clinical Variants of IMP Metallo-β-Lactamases: Analysis and Implications for Inhibitor Design.

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Title: Inhibitor Affinity Differs among Clinical Variants of IMP Metallo-β-Lactamases: Analysis and Implications for Inhibitor Design.
Authors: Thomas CA; Department of Chemistry and Biochemistry, Miami University, Oxford, Ohio 45056, United States., Alao JP; Department of Chemistry and Biochemistry, Miami University, Oxford, Ohio 45056, United States., Smisek T; Department of Molecular Biosciences, The University of Texas, Austin, Texas 78712, United States., Cheng Z; Department of Chemistry and Biochemistry, Miami University, Oxford, Ohio 45056, United States., Bethel CR; Medical Service, VA Northeast Ohio Health Care System Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio 44106, United States., Yang K; Department of Chemistry and Biochemistry, Miami University, Oxford, Ohio 45056, United States., Obaseki I; Department of Chemistry and Biochemistry, Miami University, Oxford, Ohio 45056, United States., Page RC; Department of Chemistry and Biochemistry, Miami University, Oxford, Ohio 45056, United States., Bonomo RA; Medical Service, VA Northeast Ohio Health Care System Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio 44106, United States.; Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio 45056, United States.; Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, United States.; Geriatric Research, Education and Clinical Center, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio 44106, United States.; Departments of Pharmacology, Molecular Biology & Microbiology, and Proteomics & Bioinformatics, Case Western Reserve University, Cleveland, Ohio 44106, United States.; CWRU-Cleveland VAMC Center for Antimicrobial Resistance and Epidemiology (Case VA CARES), Cleveland, Ohio 44106, United States., Oelschlaeger P; Department of Biotechnology and Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, California 91766, United States., Fast W; Department of Molecular Biosciences, The University of Texas, Austin, Texas 78712, United States., Kravats AN; Department of Chemistry and Biochemistry, Miami University, Oxford, Ohio 45056, United States., Crowder MW; Department of Chemistry and Biochemistry, Miami University, Oxford, Ohio 45056, United States.
Source: ACS infectious diseases [ACS Infect Dis] 2025 Aug 08; Vol. 11 (8), pp. 2157-2168. Date of Electronic Publication: 2025 Jul 24.
Publication Type: Journal Article
Journal Info: Publisher: ACS Publications Country of Publication: United States NLM ID: 101654580 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2373-8227 (Electronic) Linking ISSN: 23738227 NLM ISO Abbreviation: ACS Infect Dis Subsets: MEDLINE
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