View in EDS

PD-1 regulates tumor-infiltrating CD8+ T cells in both a cell-intrinsic and a cell-extrinsic fashion.

Saved in:
Bibliographic Details
Title: PD-1 regulates tumor-infiltrating CD8+ T cells in both a cell-intrinsic and a cell-extrinsic fashion.
Authors: Pauken KE; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School , Boston, MA, USA., Markson SC; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School , Boston, MA, USA.; Broad Institute of MIT and Harvard , Cambridge, MA, USA., Conway TS; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School , Boston, MA, USA., Juneja VR; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School , Boston, MA, USA.; Harvard-MIT Division of Health Sciences and Technology , Cambridge, MA, USA., Shahid O; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School , Boston, MA, USA.; Department of Data Sciences, Dana-Farber Cancer Institute, Boston, MA, USA., Burke KP; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School , Boston, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA., Rowe JH; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School , Boston, MA, USA.; Division of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Nguyen TH; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School , Boston, MA, USA., Collier JL; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School , Boston, MA, USA., Walsh JML; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School , Boston, MA, USA.; Broad Institute of MIT and Harvard , Cambridge, MA, USA.; Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Fung ME; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School , Boston, MA, USA., Luber JM; Broad Institute of MIT and Harvard , Cambridge, MA, USA.; Department of Data Sciences, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA., Ringel AE; Department of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA., Schenkel JM; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology , Cambridge, MA, USA.; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA., Freeman GJ; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA., Haigis MC; Department of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA., Singer M; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard , Cambridge, MA, USA.; Department of Data Sciences, Dana-Farber Cancer Institute, Boston, MA, USA., Sharpe AH; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School , Boston, MA, USA.; Broad Institute of MIT and Harvard , Cambridge, MA, USA.; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.
Source: The Journal of experimental medicine [J Exp Med] 2025 Oct 06; Vol. 222 (10). Date of Electronic Publication: 2025 Jul 24.
Publication Type: Journal Article
Journal Info: Publisher: Rockefeller University Press Country of Publication: United States NLM ID: 2985109R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1540-9538 (Electronic) Linking ISSN: 00221007 NLM ISO Abbreviation: J Exp Med Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 40705010
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: PD-1 regulates tumor-infiltrating CD8+ T cells in both a cell-intrinsic and a cell-extrinsic fashion.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Pauken+KE%22">Pauken KE</searchLink>; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School , Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Markson+SC%22">Markson SC</searchLink>; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School , Boston, MA, USA.; Broad Institute of MIT and Harvard , Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Conway+TS%22">Conway TS</searchLink>; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School , Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Juneja+VR%22">Juneja VR</searchLink>; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School , Boston, MA, USA.; Harvard-MIT Division of Health Sciences and Technology , Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Shahid+O%22">Shahid O</searchLink>; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School , Boston, MA, USA.; Department of Data Sciences, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Burke+KP%22">Burke KP</searchLink>; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School , Boston, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Rowe+JH%22">Rowe JH</searchLink>; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School , Boston, MA, USA.; Division of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Nguyen+TH%22">Nguyen TH</searchLink>; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School , Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Collier+JL%22">Collier JL</searchLink>; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School , Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Walsh+JML%22">Walsh JML</searchLink>; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School , Boston, MA, USA.; Broad Institute of MIT and Harvard , Cambridge, MA, USA.; Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Fung+ME%22">Fung ME</searchLink>; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School , Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Luber+JM%22">Luber JM</searchLink>; Broad Institute of MIT and Harvard , Cambridge, MA, USA.; Department of Data Sciences, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ringel+AE%22">Ringel AE</searchLink>; Department of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Schenkel+JM%22">Schenkel JM</searchLink>; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology , Cambridge, MA, USA.; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Freeman+GJ%22">Freeman GJ</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Haigis+MC%22">Haigis MC</searchLink>; Department of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Singer+M%22">Singer M</searchLink>; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard , Cambridge, MA, USA.; Department of Data Sciences, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Sharpe+AH%22">Sharpe AH</searchLink>; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School , Boston, MA, USA.; Broad Institute of MIT and Harvard , Cambridge, MA, USA.; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%222985109R%22">The Journal of experimental medicine</searchLink> [J Exp Med] 2025 Oct 06; Vol. 222 (10). <i>Date of Electronic Publication: </i>2025 Jul 24.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Rockefeller+University+Press%22">Rockefeller University Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>2985109R <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1540-9538 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200221007%22">00221007 </searchLink><i>NLM ISO Abbreviation: </i>J Exp Med <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=40705010
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1084/jem.20230542
    Languages:
      – Code: eng
        Text: English
    Titles:
      – TitleFull: PD-1 regulates tumor-infiltrating CD8+ T cells in both a cell-intrinsic and a cell-extrinsic fashion.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Pauken KE
      – PersonEntity:
          Name:
            NameFull: Markson SC
      – PersonEntity:
          Name:
            NameFull: Conway TS
      – PersonEntity:
          Name:
            NameFull: Juneja VR
      – PersonEntity:
          Name:
            NameFull: Shahid O
      – PersonEntity:
          Name:
            NameFull: Burke KP
      – PersonEntity:
          Name:
            NameFull: Rowe JH
      – PersonEntity:
          Name:
            NameFull: Nguyen TH
      – PersonEntity:
          Name:
            NameFull: Collier JL
      – PersonEntity:
          Name:
            NameFull: Walsh JML
      – PersonEntity:
          Name:
            NameFull: Fung ME
      – PersonEntity:
          Name:
            NameFull: Luber JM
      – PersonEntity:
          Name:
            NameFull: Ringel AE
      – PersonEntity:
          Name:
            NameFull: Schenkel JM
      – PersonEntity:
          Name:
            NameFull: Freeman GJ
      – PersonEntity:
          Name:
            NameFull: Haigis MC
      – PersonEntity:
          Name:
            NameFull: Singer M
      – PersonEntity:
          Name:
            NameFull: Sharpe AH
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 06
              M: 10
              Text: 2025 Oct 06
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-electronic
              Value: 1540-9538
          Numbering:
            – Type: volume
              Value: 222
            – Type: issue
              Value: 10
          Titles:
            – TitleFull: The Journal of experimental medicine
              Type: main
ResultId 1