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Polyamine Depletion by D,L-α-Difluoromethylornithine Inhibits Ewing Sarcoma Metastasis by Inducing Ferroptosis.

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Title: Polyamine Depletion by D,L-α-Difluoromethylornithine Inhibits Ewing Sarcoma Metastasis by Inducing Ferroptosis.
Authors: Offenbacher R; Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York.; Montefiore Einstein Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, New York., Jackson KW; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Department of Pediatrics, Indiana University, Indianapolis, Indiana., Hayashi M; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Department of Pediatrics-Hematology/Oncology and Bone Marrow Transplantation, University of Colorado, Aurora, Colorado., Zhang J; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York., Peng D; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland., Tan Y; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland.; Department of Microbiology and Immunology, Stanford University School of Medicine, Palo Alto, California., Stewart TM; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland., Ciero P; Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York.; Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York., Foley J; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland., Casero RA Jr; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland., Cahan P; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland., Loeb DM; Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York.; Montefiore Einstein Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, New York.; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York.; Cancer Dormancy Institute, Albert Einstein College of Medicine, Bronx, New York.; Marilyn and Stanley M. Katz Institute for Immunotherapy for Cancer and Inflammatory Disorders, Albert Einstein College of Medicine, Bronx, New York.
Source: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2025 Oct 01; Vol. 31 (19), pp. 4196-4210.
Publication Type: Journal Article
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 9502500 Publication Model: Print Cited Medium: Internet ISSN: 1557-3265 (Electronic) Linking ISSN: 10780432 NLM ISO Abbreviation: Clin Cancer Res Subsets: MEDLINE
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  Data: Polyamine Depletion by D,L-α-Difluoromethylornithine Inhibits Ewing Sarcoma Metastasis by Inducing Ferroptosis.
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  Data: <searchLink fieldCode="AU" term="%22Offenbacher+R%22">Offenbacher R</searchLink>; Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York.; Montefiore Einstein Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, New York.<br /><searchLink fieldCode="AU" term="%22Jackson+KW%22">Jackson KW</searchLink>; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Department of Pediatrics, Indiana University, Indianapolis, Indiana.<br /><searchLink fieldCode="AU" term="%22Hayashi+M%22">Hayashi M</searchLink>; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Department of Pediatrics-Hematology/Oncology and Bone Marrow Transplantation, University of Colorado, Aurora, Colorado.<br /><searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York.<br /><searchLink fieldCode="AU" term="%22Peng+D%22">Peng D</searchLink>; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland.<br /><searchLink fieldCode="AU" term="%22Tan+Y%22">Tan Y</searchLink>; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland.; Department of Microbiology and Immunology, Stanford University School of Medicine, Palo Alto, California.<br /><searchLink fieldCode="AU" term="%22Stewart+TM%22">Stewart TM</searchLink>; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.<br /><searchLink fieldCode="AU" term="%22Ciero+P%22">Ciero P</searchLink>; Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York.; Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York.<br /><searchLink fieldCode="AU" term="%22Foley+J%22">Foley J</searchLink>; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.<br /><searchLink fieldCode="AU" term="%22Casero+RA+Jr%22">Casero RA Jr</searchLink>; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.<br /><searchLink fieldCode="AU" term="%22Cahan+P%22">Cahan P</searchLink>; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland.<br /><searchLink fieldCode="AU" term="%22Loeb+DM%22">Loeb DM</searchLink>; Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York.; Montefiore Einstein Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, New York.; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York.; Cancer Dormancy Institute, Albert Einstein College of Medicine, Bronx, New York.; Marilyn and Stanley M. Katz Institute for Immunotherapy for Cancer and Inflammatory Disorders, Albert Einstein College of Medicine, Bronx, New York.
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