The thiazolidinedione drug troglitazone inhibits Gq signaling through direct binding to the Gq alpha subunit through inhibition of GDP release. - Issa NT; Shen T; Vizurraga A; Pronin A; Henry T; Wang Q; Kwarcinski FE; Schürer S; Badiavas E; Tall GG; Slepak VZ (Molecular pharmacology, 2025)