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Spinocerebellar ataxia type 3: from pathogenesis to promising therapeutics.

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Title: Spinocerebellar ataxia type 3: from pathogenesis to promising therapeutics.
Authors: Silva AC; CNC-UC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal; CIBB - Center for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal; Institute for Interdisciplinary Research, Doctoral Programme in Experimental Biology and Biomedicine (PDBEB), University of Coimbra, Coimbra, Portugal; GeneT - Gene Therapy Center of Excellence, University of Coimbra, Coimbra, Portugal., Lopes MM; CNC-UC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal; CIBB - Center for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal; Institute for Interdisciplinary Research, Doctoral Programme in Experimental Biology and Biomedicine (PDBEB), University of Coimbra, Coimbra, Portugal; GeneT - Gene Therapy Center of Excellence, University of Coimbra, Coimbra, Portugal., Lobo DD; CNC-UC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal; CIBB - Center for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal; Institute for Interdisciplinary Research, Doctoral Programme in Experimental Biology and Biomedicine (PDBEB), University of Coimbra, Coimbra, Portugal; GeneT - Gene Therapy Center of Excellence, University of Coimbra, Coimbra, Portugal., Henriques C; CNC-UC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal; CIBB - Center for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal; GeneT - Gene Therapy Center of Excellence, University of Coimbra, Coimbra, Portugal; FFUC - Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal., Pereira de Almeida L; CNC-UC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal; CIBB - Center for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal; GeneT - Gene Therapy Center of Excellence, University of Coimbra, Coimbra, Portugal; FFUC - Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal; ViraVector - Viral Vector for Gene Transfer Core Facility, University of Coimbra, Coimbra, Portugal. Electronic address: luispa@cnc.uc.pt., Nobre RJ; CNC-UC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal; CIBB - Center for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal; GeneT - Gene Therapy Center of Excellence, University of Coimbra, Coimbra, Portugal; ViraVector - Viral Vector for Gene Transfer Core Facility, University of Coimbra, Coimbra, Portugal; III-UC - Institute for Interdisciplinary Research, University of Coimbra, Coimbra, Portugal. Electronic address: rui.nobre@cnc.uc.pt.
Source: Trends in molecular medicine [Trends Mol Med] 2025 Nov; Vol. 31 (11), pp. 1065-1066. Date of Electronic Publication: 2025 Jul 23.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 100966035 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1471-499X (Electronic) Linking ISSN: 14714914 NLM ISO Abbreviation: Trends Mol Med Subsets: MEDLINE; In Process
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  Data: Spinocerebellar ataxia type 3: from pathogenesis to promising therapeutics.
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  Data: <searchLink fieldCode="AU" term="%22Silva+AC%22">Silva AC</searchLink>; CNC-UC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal; CIBB - Center for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal; Institute for Interdisciplinary Research, Doctoral Programme in Experimental Biology and Biomedicine (PDBEB), University of Coimbra, Coimbra, Portugal; GeneT - Gene Therapy Center of Excellence, University of Coimbra, Coimbra, Portugal.<br /><searchLink fieldCode="AU" term="%22Lopes+MM%22">Lopes MM</searchLink>; CNC-UC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal; CIBB - Center for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal; Institute for Interdisciplinary Research, Doctoral Programme in Experimental Biology and Biomedicine (PDBEB), University of Coimbra, Coimbra, Portugal; GeneT - Gene Therapy Center of Excellence, University of Coimbra, Coimbra, Portugal.<br /><searchLink fieldCode="AU" term="%22Lobo+DD%22">Lobo DD</searchLink>; CNC-UC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal; CIBB - Center for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal; Institute for Interdisciplinary Research, Doctoral Programme in Experimental Biology and Biomedicine (PDBEB), University of Coimbra, Coimbra, Portugal; GeneT - Gene Therapy Center of Excellence, University of Coimbra, Coimbra, Portugal.<br /><searchLink fieldCode="AU" term="%22Henriques+C%22">Henriques C</searchLink>; CNC-UC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal; CIBB - Center for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal; GeneT - Gene Therapy Center of Excellence, University of Coimbra, Coimbra, Portugal; FFUC - Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal.<br /><searchLink fieldCode="AU" term="%22Pereira+de+Almeida+L%22">Pereira de Almeida L</searchLink>; CNC-UC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal; CIBB - Center for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal; GeneT - Gene Therapy Center of Excellence, University of Coimbra, Coimbra, Portugal; FFUC - Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal; ViraVector - Viral Vector for Gene Transfer Core Facility, University of Coimbra, Coimbra, Portugal. Electronic address: luispa@cnc.uc.pt.<br /><searchLink fieldCode="AU" term="%22Nobre+RJ%22">Nobre RJ</searchLink>; CNC-UC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal; CIBB - Center for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal; GeneT - Gene Therapy Center of Excellence, University of Coimbra, Coimbra, Portugal; ViraVector - Viral Vector for Gene Transfer Core Facility, University of Coimbra, Coimbra, Portugal; III-UC - Institute for Interdisciplinary Research, University of Coimbra, Coimbra, Portugal. Electronic address: rui.nobre@cnc.uc.pt.
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              Text: 2025 Nov
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