Lowering Cardiac Branched-Chain Keto Acid Levels Enhances Cardiac Glucose Oxidation and Cardiac Efficiency via Enhancing Mitochondrial Insulin Signaling in Heart Failure.
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| Title: | Lowering Cardiac Branched-Chain Keto Acid Levels Enhances Cardiac Glucose Oxidation and Cardiac Efficiency via Enhancing Mitochondrial Insulin Signaling in Heart Failure. |
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| Authors: | Karwi QG; Department of Pharmacology, College of Medicine, University of Diyala, Baqubaa, Iraq (Q.G.K.).; Cardiovascular Research Centre (Q.G.K., L.Z., C.S.W., K.L.H., Q.S., S.P., K.P., B.A., S.D., E.K., J.L., J.R.B.D., G.D.L.), University of Alberta, Edmonton, AB, Canada.; Division of BioMedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, Saint John's, NL, Canada (Q.G.K.)., Zhang L; Cardiovascular Research Centre (Q.G.K., L.Z., C.S.W., K.L.H., Q.S., S.P., K.P., B.A., S.D., E.K., J.L., J.R.B.D., G.D.L.), University of Alberta, Edmonton, AB, Canada., Gopal K; Faculty of Pharmacy and Pharmaceutical Sciences (K.G., J.R.U.), University of Alberta, Edmonton, AB, Canada.; Mazankowski Alberta Heart Institute (K.G., J.R.U., G.D.L.), University of Alberta, Edmonton, AB, Canada.; Alberta Diabetes Institute (K.G., J.R.U., G.D.L.), University of Alberta, Edmonton, AB, Canada., Wagg CS; Cardiovascular Research Centre (Q.G.K., L.Z., C.S.W., K.L.H., Q.S., S.P., K.P., B.A., S.D., E.K., J.L., J.R.B.D., G.D.L.), University of Alberta, Edmonton, AB, Canada., Ho KL; Cardiovascular Research Centre (Q.G.K., L.Z., C.S.W., K.L.H., Q.S., S.P., K.P., B.A., S.D., E.K., J.L., J.R.B.D., G.D.L.), University of Alberta, Edmonton, AB, Canada., Sun Q; Cardiovascular Research Centre (Q.G.K., L.Z., C.S.W., K.L.H., Q.S., S.P., K.P., B.A., S.D., E.K., J.L., J.R.B.D., G.D.L.), University of Alberta, Edmonton, AB, Canada., Panidarapu S; Cardiovascular Research Centre (Q.G.K., L.Z., C.S.W., K.L.H., Q.S., S.P., K.P., B.A., S.D., E.K., J.L., J.R.B.D., G.D.L.), University of Alberta, Edmonton, AB, Canada., Persad K; Cardiovascular Research Centre (Q.G.K., L.Z., C.S.W., K.L.H., Q.S., S.P., K.P., B.A., S.D., E.K., J.L., J.R.B.D., G.D.L.), University of Alberta, Edmonton, AB, Canada., Altuany B; Cardiovascular Research Centre (Q.G.K., L.Z., C.S.W., K.L.H., Q.S., S.P., K.P., B.A., S.D., E.K., J.L., J.R.B.D., G.D.L.), University of Alberta, Edmonton, AB, Canada., Damen S; Cardiovascular Research Centre (Q.G.K., L.Z., C.S.W., K.L.H., Q.S., S.P., K.P., B.A., S.D., E.K., J.L., J.R.B.D., G.D.L.), University of Alberta, Edmonton, AB, Canada., Ketema E; Cardiovascular Research Centre (Q.G.K., L.Z., C.S.W., K.L.H., Q.S., S.P., K.P., B.A., S.D., E.K., J.L., J.R.B.D., G.D.L.), University of Alberta, Edmonton, AB, Canada., Levasseur J; Cardiovascular Research Centre (Q.G.K., L.Z., C.S.W., K.L.H., Q.S., S.P., K.P., B.A., S.D., E.K., J.L., J.R.B.D., G.D.L.), University of Alberta, Edmonton, AB, Canada., Pulinilkunnil T; Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, NS, Canada (T.P.)., Ussher JR; Faculty of Pharmacy and Pharmaceutical Sciences (K.G., J.R.U.), University of Alberta, Edmonton, AB, Canada.; Mazankowski Alberta Heart Institute (K.G., J.R.U., G.D.L.), University of Alberta, Edmonton, AB, Canada.; Alberta Diabetes Institute (K.G., J.R.U., G.D.L.), University of Alberta, Edmonton, AB, Canada., Dyck JRB; Cardiovascular Research Centre (Q.G.K., L.Z., C.S.W., K.L.H., Q.S., S.P., K.P., B.A., S.D., E.K., J.L., J.R.B.D., G.D.L.), University of Alberta, Edmonton, AB, Canada., Lopaschuk GD; Cardiovascular Research Centre (Q.G.K., L.Z., C.S.W., K.L.H., Q.S., S.P., K.P., B.A., S.D., E.K., J.L., J.R.B.D., G.D.L.), University of Alberta, Edmonton, AB, Canada.; Mazankowski Alberta Heart Institute (K.G., J.R.U., G.D.L.), University of Alberta, Edmonton, AB, Canada.; Alberta Diabetes Institute (K.G., J.R.U., G.D.L.), University of Alberta, Edmonton, AB, Canada. |
| Source: | Circulation. Heart failure [Circ Heart Fail] 2025 Sep; Vol. 18 (9), pp. e012012. Date of Electronic Publication: 2025 Jul 25. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 101479941 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1941-3297 (Electronic) Linking ISSN: 19413289 NLM ISO Abbreviation: Circ Heart Fail Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 40709461 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Lowering Cardiac Branched-Chain Keto Acid Levels Enhances Cardiac Glucose Oxidation and Cardiac Efficiency via Enhancing Mitochondrial Insulin Signaling in Heart Failure. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Karwi+QG%22">Karwi QG</searchLink>; Department of Pharmacology, College of Medicine, University of Diyala, Baqubaa, Iraq (Q.G.K.).; Cardiovascular Research Centre (Q.G.K., L.Z., C.S.W., K.L.H., Q.S., S.P., K.P., B.A., S.D., E.K., J.L., J.R.B.D., G.D.L.), University of Alberta, Edmonton, AB, Canada.; Division of BioMedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, Saint John's, NL, Canada (Q.G.K.).<br /><searchLink fieldCode="AU" term="%22Zhang+L%22">Zhang L</searchLink>; Cardiovascular Research Centre (Q.G.K., L.Z., C.S.W., K.L.H., Q.S., S.P., K.P., B.A., S.D., E.K., J.L., J.R.B.D., G.D.L.), University of Alberta, Edmonton, AB, Canada.<br /><searchLink fieldCode="AU" term="%22Gopal+K%22">Gopal K</searchLink>; Faculty of Pharmacy and Pharmaceutical Sciences (K.G., J.R.U.), University of Alberta, Edmonton, AB, Canada.; Mazankowski Alberta Heart Institute (K.G., J.R.U., G.D.L.), University of Alberta, Edmonton, AB, Canada.; Alberta Diabetes Institute (K.G., J.R.U., G.D.L.), University of Alberta, Edmonton, AB, Canada.<br /><searchLink fieldCode="AU" term="%22Wagg+CS%22">Wagg CS</searchLink>; Cardiovascular Research Centre (Q.G.K., L.Z., C.S.W., K.L.H., Q.S., S.P., K.P., B.A., S.D., E.K., J.L., J.R.B.D., G.D.L.), University of Alberta, Edmonton, AB, Canada.<br /><searchLink fieldCode="AU" term="%22Ho+KL%22">Ho KL</searchLink>; Cardiovascular Research Centre (Q.G.K., L.Z., C.S.W., K.L.H., Q.S., S.P., K.P., B.A., S.D., E.K., J.L., J.R.B.D., G.D.L.), University of Alberta, Edmonton, AB, Canada.<br /><searchLink fieldCode="AU" term="%22Sun+Q%22">Sun Q</searchLink>; Cardiovascular Research Centre (Q.G.K., L.Z., C.S.W., K.L.H., Q.S., S.P., K.P., B.A., S.D., E.K., J.L., J.R.B.D., G.D.L.), University of Alberta, Edmonton, AB, Canada.<br /><searchLink fieldCode="AU" term="%22Panidarapu+S%22">Panidarapu S</searchLink>; Cardiovascular Research Centre (Q.G.K., L.Z., C.S.W., K.L.H., Q.S., S.P., K.P., B.A., S.D., E.K., J.L., J.R.B.D., G.D.L.), University of Alberta, Edmonton, AB, Canada.<br /><searchLink fieldCode="AU" term="%22Persad+K%22">Persad K</searchLink>; Cardiovascular Research Centre (Q.G.K., L.Z., C.S.W., K.L.H., Q.S., S.P., K.P., B.A., S.D., E.K., J.L., J.R.B.D., G.D.L.), University of Alberta, Edmonton, AB, Canada.<br /><searchLink fieldCode="AU" term="%22Altuany+B%22">Altuany B</searchLink>; Cardiovascular Research Centre (Q.G.K., L.Z., C.S.W., K.L.H., Q.S., S.P., K.P., B.A., S.D., E.K., J.L., J.R.B.D., G.D.L.), University of Alberta, Edmonton, AB, Canada.<br /><searchLink fieldCode="AU" term="%22Damen+S%22">Damen S</searchLink>; Cardiovascular Research Centre (Q.G.K., L.Z., C.S.W., K.L.H., Q.S., S.P., K.P., B.A., S.D., E.K., J.L., J.R.B.D., G.D.L.), University of Alberta, Edmonton, AB, Canada.<br /><searchLink fieldCode="AU" term="%22Ketema+E%22">Ketema E</searchLink>; Cardiovascular Research Centre (Q.G.K., L.Z., C.S.W., K.L.H., Q.S., S.P., K.P., B.A., S.D., E.K., J.L., J.R.B.D., G.D.L.), University of Alberta, Edmonton, AB, Canada.<br /><searchLink fieldCode="AU" term="%22Levasseur+J%22">Levasseur J</searchLink>; Cardiovascular Research Centre (Q.G.K., L.Z., C.S.W., K.L.H., Q.S., S.P., K.P., B.A., S.D., E.K., J.L., J.R.B.D., G.D.L.), University of Alberta, Edmonton, AB, Canada.<br /><searchLink fieldCode="AU" term="%22Pulinilkunnil+T%22">Pulinilkunnil T</searchLink>; Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, NS, Canada (T.P.).<br /><searchLink fieldCode="AU" term="%22Ussher+JR%22">Ussher JR</searchLink>; Faculty of Pharmacy and Pharmaceutical Sciences (K.G., J.R.U.), University of Alberta, Edmonton, AB, Canada.; Mazankowski Alberta Heart Institute (K.G., J.R.U., G.D.L.), University of Alberta, Edmonton, AB, Canada.; Alberta Diabetes Institute (K.G., J.R.U., G.D.L.), University of Alberta, Edmonton, AB, Canada.<br /><searchLink fieldCode="AU" term="%22Dyck+JRB%22">Dyck JRB</searchLink>; Cardiovascular Research Centre (Q.G.K., L.Z., C.S.W., K.L.H., Q.S., S.P., K.P., B.A., S.D., E.K., J.L., J.R.B.D., G.D.L.), University of Alberta, Edmonton, AB, Canada.<br /><searchLink fieldCode="AU" term="%22Lopaschuk+GD%22">Lopaschuk GD</searchLink>; Cardiovascular Research Centre (Q.G.K., L.Z., C.S.W., K.L.H., Q.S., S.P., K.P., B.A., S.D., E.K., J.L., J.R.B.D., G.D.L.), University of Alberta, Edmonton, AB, Canada.; Mazankowski Alberta Heart Institute (K.G., J.R.U., G.D.L.), University of Alberta, Edmonton, AB, Canada.; Alberta Diabetes Institute (K.G., J.R.U., G.D.L.), University of Alberta, Edmonton, AB, Canada. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101479941%22">Circulation. Heart failure</searchLink> [Circ Heart Fail] 2025 Sep; Vol. 18 (9), pp. e012012. <i>Date of Electronic Publication: </i>2025 Jul 25. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Lippincott+Williams+%26+Wilkins%22">Lippincott Williams & Wilkins </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101479941 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1941-3297 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2219413289%22">19413289 </searchLink><i>NLM ISO Abbreviation: </i>Circ Heart Fail <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=40709461 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1161/CIRCHEARTFAILURE.124.012012 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: e012012 Titles: – TitleFull: Lowering Cardiac Branched-Chain Keto Acid Levels Enhances Cardiac Glucose Oxidation and Cardiac Efficiency via Enhancing Mitochondrial Insulin Signaling in Heart Failure. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Karwi QG – PersonEntity: Name: NameFull: Zhang L – PersonEntity: Name: NameFull: Gopal K – PersonEntity: Name: NameFull: Wagg CS – PersonEntity: Name: NameFull: Ho KL – PersonEntity: Name: NameFull: Sun Q – PersonEntity: Name: NameFull: Panidarapu S – PersonEntity: Name: NameFull: Persad K – PersonEntity: Name: NameFull: Altuany B – PersonEntity: Name: NameFull: Damen S – PersonEntity: Name: NameFull: Ketema E – PersonEntity: Name: NameFull: Levasseur J – PersonEntity: Name: NameFull: Pulinilkunnil T – PersonEntity: Name: NameFull: Ussher JR – PersonEntity: Name: NameFull: Dyck JRB – PersonEntity: Name: NameFull: Lopaschuk GD IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 09 Text: 2025 Sep Type: published Y: 2025 Identifiers: – Type: issn-electronic Value: 1941-3297 Numbering: – Type: volume Value: 18 – Type: issue Value: 9 Titles: – TitleFull: Circulation. Heart failure Type: main |
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