Lowering Cardiac Branched-Chain Keto Acid Levels Enhances Cardiac Glucose Oxidation and Cardiac Efficiency via Enhancing Mitochondrial Insulin Signaling in Heart Failure.
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| Title: | Lowering Cardiac Branched-Chain Keto Acid Levels Enhances Cardiac Glucose Oxidation and Cardiac Efficiency via Enhancing Mitochondrial Insulin Signaling in Heart Failure. |
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| Authors: | Karwi QG; Department of Pharmacology, College of Medicine, University of Diyala, Baqubaa, Iraq (Q.G.K.).; Cardiovascular Research Centre (Q.G.K., L.Z., C.S.W., K.L.H., Q.S., S.P., K.P., B.A., S.D., E.K., J.L., J.R.B.D., G.D.L.), University of Alberta, Edmonton, AB, Canada.; Division of BioMedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, Saint John's, NL, Canada (Q.G.K.)., Zhang L; Cardiovascular Research Centre (Q.G.K., L.Z., C.S.W., K.L.H., Q.S., S.P., K.P., B.A., S.D., E.K., J.L., J.R.B.D., G.D.L.), University of Alberta, Edmonton, AB, Canada., Gopal K; Faculty of Pharmacy and Pharmaceutical Sciences (K.G., J.R.U.), University of Alberta, Edmonton, AB, Canada.; Mazankowski Alberta Heart Institute (K.G., J.R.U., G.D.L.), University of Alberta, Edmonton, AB, Canada.; Alberta Diabetes Institute (K.G., J.R.U., G.D.L.), University of Alberta, Edmonton, AB, Canada., Wagg CS; Cardiovascular Research Centre (Q.G.K., L.Z., C.S.W., K.L.H., Q.S., S.P., K.P., B.A., S.D., E.K., J.L., J.R.B.D., G.D.L.), University of Alberta, Edmonton, AB, Canada., Ho KL; Cardiovascular Research Centre (Q.G.K., L.Z., C.S.W., K.L.H., Q.S., S.P., K.P., B.A., S.D., E.K., J.L., J.R.B.D., G.D.L.), University of Alberta, Edmonton, AB, Canada., Sun Q; Cardiovascular Research Centre (Q.G.K., L.Z., C.S.W., K.L.H., Q.S., S.P., K.P., B.A., S.D., E.K., J.L., J.R.B.D., G.D.L.), University of Alberta, Edmonton, AB, Canada., Panidarapu S; Cardiovascular Research Centre (Q.G.K., L.Z., C.S.W., K.L.H., Q.S., S.P., K.P., B.A., S.D., E.K., J.L., J.R.B.D., G.D.L.), University of Alberta, Edmonton, AB, Canada., Persad K; Cardiovascular Research Centre (Q.G.K., L.Z., C.S.W., K.L.H., Q.S., S.P., K.P., B.A., S.D., E.K., J.L., J.R.B.D., G.D.L.), University of Alberta, Edmonton, AB, Canada., Altuany B; Cardiovascular Research Centre (Q.G.K., L.Z., C.S.W., K.L.H., Q.S., S.P., K.P., B.A., S.D., E.K., J.L., J.R.B.D., G.D.L.), University of Alberta, Edmonton, AB, Canada., Damen S; Cardiovascular Research Centre (Q.G.K., L.Z., C.S.W., K.L.H., Q.S., S.P., K.P., B.A., S.D., E.K., J.L., J.R.B.D., G.D.L.), University of Alberta, Edmonton, AB, Canada., Ketema E; Cardiovascular Research Centre (Q.G.K., L.Z., C.S.W., K.L.H., Q.S., S.P., K.P., B.A., S.D., E.K., J.L., J.R.B.D., G.D.L.), University of Alberta, Edmonton, AB, Canada., Levasseur J; Cardiovascular Research Centre (Q.G.K., L.Z., C.S.W., K.L.H., Q.S., S.P., K.P., B.A., S.D., E.K., J.L., J.R.B.D., G.D.L.), University of Alberta, Edmonton, AB, Canada., Pulinilkunnil T; Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, NS, Canada (T.P.)., Ussher JR; Faculty of Pharmacy and Pharmaceutical Sciences (K.G., J.R.U.), University of Alberta, Edmonton, AB, Canada.; Mazankowski Alberta Heart Institute (K.G., J.R.U., G.D.L.), University of Alberta, Edmonton, AB, Canada.; Alberta Diabetes Institute (K.G., J.R.U., G.D.L.), University of Alberta, Edmonton, AB, Canada., Dyck JRB; Cardiovascular Research Centre (Q.G.K., L.Z., C.S.W., K.L.H., Q.S., S.P., K.P., B.A., S.D., E.K., J.L., J.R.B.D., G.D.L.), University of Alberta, Edmonton, AB, Canada., Lopaschuk GD; Cardiovascular Research Centre (Q.G.K., L.Z., C.S.W., K.L.H., Q.S., S.P., K.P., B.A., S.D., E.K., J.L., J.R.B.D., G.D.L.), University of Alberta, Edmonton, AB, Canada.; Mazankowski Alberta Heart Institute (K.G., J.R.U., G.D.L.), University of Alberta, Edmonton, AB, Canada.; Alberta Diabetes Institute (K.G., J.R.U., G.D.L.), University of Alberta, Edmonton, AB, Canada. |
| Source: | Circulation. Heart failure [Circ Heart Fail] 2025 Sep; Vol. 18 (9), pp. e012012. Date of Electronic Publication: 2025 Jul 25. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 101479941 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1941-3297 (Electronic) Linking ISSN: 19413289 NLM ISO Abbreviation: Circ Heart Fail Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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