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2-Hydroxybenzylamine for Treatment of Atrial Fibrillation: A First-in-Human Clinical Pilot Trial.

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Title: 2-Hydroxybenzylamine for Treatment of Atrial Fibrillation: A First-in-Human Clinical Pilot Trial.
Authors: Yoneda ZT; Department of Medicine, Division of Cardiovascular Medicine (Z.T.Y., D.M.C., M.A.E.-H., J.M., S.T.S., J.C.E., P.J.S., C.R.E., T.R., A.K., G.H.C., M.B.S.), Vanderbilt University Medical Center, Nashville, TN., O'Neill M; Vanderbilt University School of Medicine, Nashville, TN (M.O.N.)., Crawford DM; Department of Medicine, Division of Cardiovascular Medicine (Z.T.Y., D.M.C., M.A.E.-H., J.M., S.T.S., J.C.E., P.J.S., C.R.E., T.R., A.K., G.H.C., M.B.S.), Vanderbilt University Medical Center, Nashville, TN., Ao M; Department of Pharmacology (M.A.), Vanderbilt University Medical Center, Nashville, TN., Sun L; Department of Biostatistics (L.S., F.Y.), Vanderbilt University Medical Center, Nashville, TN., El-Harasis MA; Department of Medicine, Division of Cardiovascular Medicine (Z.T.Y., D.M.C., M.A.E.-H., J.M., S.T.S., J.C.E., P.J.S., C.R.E., T.R., A.K., G.H.C., M.B.S.), Vanderbilt University Medical Center, Nashville, TN., Pitchford L; MTI Biotech, Inc, Iowa State University Research Park, Ames (L.P., J.A.R.)., Rathmacher JA; MTI Biotech, Inc, Iowa State University Research Park, Ames (L.P., J.A.R.)., Montgomery J; Department of Medicine, Division of Cardiovascular Medicine (Z.T.Y., D.M.C., M.A.E.-H., J.M., S.T.S., J.C.E., P.J.S., C.R.E., T.R., A.K., G.H.C., M.B.S.), Vanderbilt University Medical Center, Nashville, TN., Shen ST; Department of Medicine, Division of Cardiovascular Medicine (Z.T.Y., D.M.C., M.A.E.-H., J.M., S.T.S., J.C.E., P.J.S., C.R.E., T.R., A.K., G.H.C., M.B.S.), Vanderbilt University Medical Center, Nashville, TN., Estrada JC; Department of Medicine, Division of Cardiovascular Medicine (Z.T.Y., D.M.C., M.A.E.-H., J.M., S.T.S., J.C.E., P.J.S., C.R.E., T.R., A.K., G.H.C., M.B.S.), Vanderbilt University Medical Center, Nashville, TN., Saavedra PJ; Department of Medicine, Division of Cardiovascular Medicine (Z.T.Y., D.M.C., M.A.E.-H., J.M., S.T.S., J.C.E., P.J.S., C.R.E., T.R., A.K., G.H.C., M.B.S.), Vanderbilt University Medical Center, Nashville, TN., Ellis CR; Department of Medicine, Division of Cardiovascular Medicine (Z.T.Y., D.M.C., M.A.E.-H., J.M., S.T.S., J.C.E., P.J.S., C.R.E., T.R., A.K., G.H.C., M.B.S.), Vanderbilt University Medical Center, Nashville, TN., Richardson T; Department of Medicine, Division of Cardiovascular Medicine (Z.T.Y., D.M.C., M.A.E.-H., J.M., S.T.S., J.C.E., P.J.S., C.R.E., T.R., A.K., G.H.C., M.B.S.), Vanderbilt University Medical Center, Nashville, TN., Kangasundram A; Department of Medicine, Division of Cardiovascular Medicine (Z.T.Y., D.M.C., M.A.E.-H., J.M., S.T.S., J.C.E., P.J.S., C.R.E., T.R., A.K., G.H.C., M.B.S.), Vanderbilt University Medical Center, Nashville, TN., Crossley GH; Department of Medicine, Division of Cardiovascular Medicine (Z.T.Y., D.M.C., M.A.E.-H., J.M., S.T.S., J.C.E., P.J.S., C.R.E., T.R., A.K., G.H.C., M.B.S.), Vanderbilt University Medical Center, Nashville, TN., Akers WS; Department of Pharmaceutical Science, Lipscomb University, Nashville, TN (W.S.A.)., Ye F; Department of Biostatistics (L.S., F.Y.), Vanderbilt University Medical Center, Nashville, TN., Roden DM; Departments of Medicine, Pharmacology, and Biomedical Informatics, Divisions of Cardiovascular Medicine and Clinical Pharmacology (D.M.R.), Vanderbilt University Medical Center, Nashville, TN., Michaud GF; Beth Israel Deaconess Medical Center, Boston, MA (G.F.M.)., Shoemaker MB; Department of Medicine, Division of Cardiovascular Medicine (Z.T.Y., D.M.C., M.A.E.-H., J.M., S.T.S., J.C.E., P.J.S., C.R.E., T.R., A.K., G.H.C., M.B.S.), Vanderbilt University Medical Center, Nashville, TN.
Source: Circulation. Arrhythmia and electrophysiology [Circ Arrhythm Electrophysiol] 2025 Aug; Vol. 18 (8), pp. e013378. Date of Electronic Publication: 2025 Jul 25.
Publication Type: Journal Article; Randomized Controlled Trial
Journal Info: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 101474365 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1941-3084 (Electronic) Linking ISSN: 19413084 NLM ISO Abbreviation: Circ Arrhythm Electrophysiol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: 2-Hydroxybenzylamine for Treatment of Atrial Fibrillation: A First-in-Human Clinical Pilot Trial.
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  Data: <searchLink fieldCode="AU" term="%22Yoneda+ZT%22">Yoneda ZT</searchLink>; Department of Medicine, Division of Cardiovascular Medicine (Z.T.Y., D.M.C., M.A.E.-H., J.M., S.T.S., J.C.E., P.J.S., C.R.E., T.R., A.K., G.H.C., M.B.S.), Vanderbilt University Medical Center, Nashville, TN.<br /><searchLink fieldCode="AU" term="%22O'Neill+M%22">O'Neill M</searchLink>; Vanderbilt University School of Medicine, Nashville, TN (M.O.N.).<br /><searchLink fieldCode="AU" term="%22Crawford+DM%22">Crawford DM</searchLink>; Department of Medicine, Division of Cardiovascular Medicine (Z.T.Y., D.M.C., M.A.E.-H., J.M., S.T.S., J.C.E., P.J.S., C.R.E., T.R., A.K., G.H.C., M.B.S.), Vanderbilt University Medical Center, Nashville, TN.<br /><searchLink fieldCode="AU" term="%22Ao+M%22">Ao M</searchLink>; Department of Pharmacology (M.A.), Vanderbilt University Medical Center, Nashville, TN.<br /><searchLink fieldCode="AU" term="%22Sun+L%22">Sun L</searchLink>; Department of Biostatistics (L.S., F.Y.), Vanderbilt University Medical Center, Nashville, TN.<br /><searchLink fieldCode="AU" term="%22El-Harasis+MA%22">El-Harasis MA</searchLink>; Department of Medicine, Division of Cardiovascular Medicine (Z.T.Y., D.M.C., M.A.E.-H., J.M., S.T.S., J.C.E., P.J.S., C.R.E., T.R., A.K., G.H.C., M.B.S.), Vanderbilt University Medical Center, Nashville, TN.<br /><searchLink fieldCode="AU" term="%22Pitchford+L%22">Pitchford L</searchLink>; MTI Biotech, Inc, Iowa State University Research Park, Ames (L.P., J.A.R.).<br /><searchLink fieldCode="AU" term="%22Rathmacher+JA%22">Rathmacher JA</searchLink>; MTI Biotech, Inc, Iowa State University Research Park, Ames (L.P., J.A.R.).<br /><searchLink fieldCode="AU" term="%22Montgomery+J%22">Montgomery J</searchLink>; Department of Medicine, Division of Cardiovascular Medicine (Z.T.Y., D.M.C., M.A.E.-H., J.M., S.T.S., J.C.E., P.J.S., C.R.E., T.R., A.K., G.H.C., M.B.S.), Vanderbilt University Medical Center, Nashville, TN.<br /><searchLink fieldCode="AU" term="%22Shen+ST%22">Shen ST</searchLink>; Department of Medicine, Division of Cardiovascular Medicine (Z.T.Y., D.M.C., M.A.E.-H., J.M., S.T.S., J.C.E., P.J.S., C.R.E., T.R., A.K., G.H.C., M.B.S.), Vanderbilt University Medical Center, Nashville, TN.<br /><searchLink fieldCode="AU" term="%22Estrada+JC%22">Estrada JC</searchLink>; Department of Medicine, Division of Cardiovascular Medicine (Z.T.Y., D.M.C., M.A.E.-H., J.M., S.T.S., J.C.E., P.J.S., C.R.E., T.R., A.K., G.H.C., M.B.S.), Vanderbilt University Medical Center, Nashville, TN.<br /><searchLink fieldCode="AU" term="%22Saavedra+PJ%22">Saavedra PJ</searchLink>; Department of Medicine, Division of Cardiovascular Medicine (Z.T.Y., D.M.C., M.A.E.-H., J.M., S.T.S., J.C.E., P.J.S., C.R.E., T.R., A.K., G.H.C., M.B.S.), Vanderbilt University Medical Center, Nashville, TN.<br /><searchLink fieldCode="AU" term="%22Ellis+CR%22">Ellis CR</searchLink>; Department of Medicine, Division of Cardiovascular Medicine (Z.T.Y., D.M.C., M.A.E.-H., J.M., S.T.S., J.C.E., P.J.S., C.R.E., T.R., A.K., G.H.C., M.B.S.), Vanderbilt University Medical Center, Nashville, TN.<br /><searchLink fieldCode="AU" term="%22Richardson+T%22">Richardson T</searchLink>; Department of Medicine, Division of Cardiovascular Medicine (Z.T.Y., D.M.C., M.A.E.-H., J.M., S.T.S., J.C.E., P.J.S., C.R.E., T.R., A.K., G.H.C., M.B.S.), Vanderbilt University Medical Center, Nashville, TN.<br /><searchLink fieldCode="AU" term="%22Kangasundram+A%22">Kangasundram A</searchLink>; Department of Medicine, Division of Cardiovascular Medicine (Z.T.Y., D.M.C., M.A.E.-H., J.M., S.T.S., J.C.E., P.J.S., C.R.E., T.R., A.K., G.H.C., M.B.S.), Vanderbilt University Medical Center, Nashville, TN.<br /><searchLink fieldCode="AU" term="%22Crossley+GH%22">Crossley GH</searchLink>; Department of Medicine, Division of Cardiovascular Medicine (Z.T.Y., D.M.C., M.A.E.-H., J.M., S.T.S., J.C.E., P.J.S., C.R.E., T.R., A.K., G.H.C., M.B.S.), Vanderbilt University Medical Center, Nashville, TN.<br /><searchLink fieldCode="AU" term="%22Akers+WS%22">Akers WS</searchLink>; Department of Pharmaceutical Science, Lipscomb University, Nashville, TN (W.S.A.).<br /><searchLink fieldCode="AU" term="%22Ye+F%22">Ye F</searchLink>; Department of Biostatistics (L.S., F.Y.), Vanderbilt University Medical Center, Nashville, TN.<br /><searchLink fieldCode="AU" term="%22Roden+DM%22">Roden DM</searchLink>; Departments of Medicine, Pharmacology, and Biomedical Informatics, Divisions of Cardiovascular Medicine and Clinical Pharmacology (D.M.R.), Vanderbilt University Medical Center, Nashville, TN.<br /><searchLink fieldCode="AU" term="%22Michaud+GF%22">Michaud GF</searchLink>; Beth Israel Deaconess Medical Center, Boston, MA (G.F.M.).<br /><searchLink fieldCode="AU" term="%22Shoemaker+MB%22">Shoemaker MB</searchLink>; Department of Medicine, Division of Cardiovascular Medicine (Z.T.Y., D.M.C., M.A.E.-H., J.M., S.T.S., J.C.E., P.J.S., C.R.E., T.R., A.K., G.H.C., M.B.S.), Vanderbilt University Medical Center, Nashville, TN.
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  Data: <searchLink fieldCode="JN" term="%22101474365%22">Circulation. Arrhythmia and electrophysiology</searchLink> [Circ Arrhythm Electrophysiol] 2025 Aug; Vol. 18 (8), pp. e013378. <i>Date of Electronic Publication: </i>2025 Jul 25.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Lippincott+Williams+%26+Wilkins%22">Lippincott Williams & Wilkins </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101474365 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1941-3084 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2219413084%22">19413084 </searchLink><i>NLM ISO Abbreviation: </i>Circ Arrhythm Electrophysiol <i>Subsets: </i>MEDLINE
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