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Integrated multiomics of pressure overload in the human heart prioritizes targets relevant to heart failure.

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Title: Integrated multiomics of pressure overload in the human heart prioritizes targets relevant to heart failure.
Authors: Lindman BR; Vanderbilt Translational and Clinical Cardiovascular Research Center, Vanderbilt University School of Medicine, Nashville, TN, USA. brian.r.lindman@vumc.org., Perry AS; Vanderbilt Translational and Clinical Cardiovascular Research Center, Vanderbilt University School of Medicine, Nashville, TN, USA., Lance ML; Masonic Medical Research Institute, Utica, NY, USA., Amancherla K; Vanderbilt Translational and Clinical Cardiovascular Research Center, Vanderbilt University School of Medicine, Nashville, TN, USA., Kim N; Vanderbilt Translational and Clinical Cardiovascular Research Center, Vanderbilt University School of Medicine, Nashville, TN, USA., Sheng Q; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA., Lin P; Vanderbilt Translational and Clinical Cardiovascular Research Center, Vanderbilt University School of Medicine, Nashville, TN, USA., Pfeiffer RD; Masonic Medical Research Institute, Utica, NY, USA., Farber-Eger E; Vanderbilt Translational and Clinical Cardiovascular Research Center, Vanderbilt University School of Medicine, Nashville, TN, USA., Fearon WF; Department of Medicine, Division of Cardiology, Stanford Medical Center, Palo Alto, CA, USA., Kapadia S; Department of Medicine, Division of Cardiology, Cleveland Clinic Foundation, Cleveland, OH, USA., Kumbhani DJ; Department of Medicine, Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, TX, USA., Gillam L; Department of Cardiovascular Medicine, Morristown Medical Center, Morristown, NJ, USA., Mallugari RR; Vanderbilt Translational and Clinical Cardiovascular Research Center, Vanderbilt University School of Medicine, Nashville, TN, USA., Gupta DK; Vanderbilt Translational and Clinical Cardiovascular Research Center, Vanderbilt University School of Medicine, Nashville, TN, USA., Miller FJ; Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN, USA.; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Vatterott A; Vanderbilt Translational and Clinical Cardiovascular Research Center, Vanderbilt University School of Medicine, Nashville, TN, USA., Jackson N; Vanderbilt Translational and Clinical Cardiovascular Research Center, Vanderbilt University School of Medicine, Nashville, TN, USA., Su YR; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Tomasek K; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Absi T; Department of Cardiac Surgery, Vanderbilt University Medical Center, Nashville, TN, USA., Freedman JE; Vanderbilt Translational and Clinical Cardiovascular Research Center, Vanderbilt University School of Medicine, Nashville, TN, USA., Nayor M; Department of Cardiovascular Medicine, Boston University, Boston, MA, USA., Das S; Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Wells QS; Vanderbilt Translational and Clinical Cardiovascular Research Center, Vanderbilt University School of Medicine, Nashville, TN, USA., Dweck MR; BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK., Gerszten RE; Cardiovascular Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Gamazon ER; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Tucker NR; Masonic Medical Research Institute, Utica, NY, USA. tuckern@upstate.edu., Shah R; Vanderbilt Translational and Clinical Cardiovascular Research Center, Vanderbilt University School of Medicine, Nashville, TN, USA. ravi.shah@vumc.org., Elmariah S; Department of Medicine, Division of Cardiology, University of California, San Francisco, CA, USA. Sammy.Elmariah@ucsf.edu.
Source: Nature communications [Nat Commun] 2025 Jul 26; Vol. 16 (1), pp. 6889. Date of Electronic Publication: 2025 Jul 26.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Lindman+BR%22">Lindman BR</searchLink>; Vanderbilt Translational and Clinical Cardiovascular Research Center, Vanderbilt University School of Medicine, Nashville, TN, USA. brian.r.lindman@vumc.org.<br /><searchLink fieldCode="AU" term="%22Perry+AS%22">Perry AS</searchLink>; Vanderbilt Translational and Clinical Cardiovascular Research Center, Vanderbilt University School of Medicine, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Lance+ML%22">Lance ML</searchLink>; Masonic Medical Research Institute, Utica, NY, USA.<br /><searchLink fieldCode="AU" term="%22Amancherla+K%22">Amancherla K</searchLink>; Vanderbilt Translational and Clinical Cardiovascular Research Center, Vanderbilt University School of Medicine, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Kim+N%22">Kim N</searchLink>; Vanderbilt Translational and Clinical Cardiovascular Research Center, Vanderbilt University School of Medicine, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Sheng+Q%22">Sheng Q</searchLink>; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Lin+P%22">Lin P</searchLink>; Vanderbilt Translational and Clinical Cardiovascular Research Center, Vanderbilt University School of Medicine, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Pfeiffer+RD%22">Pfeiffer RD</searchLink>; Masonic Medical Research Institute, Utica, NY, USA.<br /><searchLink fieldCode="AU" term="%22Farber-Eger+E%22">Farber-Eger E</searchLink>; Vanderbilt Translational and Clinical Cardiovascular Research Center, Vanderbilt University School of Medicine, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Fearon+WF%22">Fearon WF</searchLink>; Department of Medicine, Division of Cardiology, Stanford Medical Center, Palo Alto, CA, USA.<br /><searchLink fieldCode="AU" term="%22Kapadia+S%22">Kapadia S</searchLink>; Department of Medicine, Division of Cardiology, Cleveland Clinic Foundation, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Kumbhani+DJ%22">Kumbhani DJ</searchLink>; 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Vanderbilt Translational and Clinical Cardiovascular Research Center, Vanderbilt University School of Medicine, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Jackson+N%22">Jackson N</searchLink>; Vanderbilt Translational and Clinical Cardiovascular Research Center, Vanderbilt University School of Medicine, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Su+YR%22">Su YR</searchLink>; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Tomasek+K%22">Tomasek K</searchLink>; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Absi+T%22">Absi T</searchLink>; Department of Cardiac Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Freedman+JE%22">Freedman JE</searchLink>; Vanderbilt Translational and Clinical Cardiovascular Research Center, Vanderbilt University School of Medicine, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Nayor+M%22">Nayor M</searchLink>; 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Masonic Medical Research Institute, Utica, NY, USA. tuckern@upstate.edu.<br /><searchLink fieldCode="AU" term="%22Shah+R%22">Shah R</searchLink>; Vanderbilt Translational and Clinical Cardiovascular Research Center, Vanderbilt University School of Medicine, Nashville, TN, USA. ravi.shah@vumc.org.<br /><searchLink fieldCode="AU" term="%22Elmariah+S%22">Elmariah S</searchLink>; Department of Medicine, Division of Cardiology, University of California, San Francisco, CA, USA. Sammy.Elmariah@ucsf.edu.
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