The transcription complex p52-ETS1 is essential for germinal center formation.

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Title: The transcription complex p52-ETS1 is essential for germinal center formation.
Authors: Morgan D; Laboratory of NF-κB Signalling, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore, Singapore.; Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Zhang B; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR)Immunos, Singapore, Singapore., Fidan K; Laboratory of NF-κB Signalling, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore, Singapore., Pan W; Faculty of Health Sciences, University of Macau, Taipa, China., Vaiyapuri TS; Laboratory of NF-κB Signalling, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore, Singapore., Raju A; Laboratory of NF-κB Signalling, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore, Singapore., Hei D; Laboratory of NF-κB Signalling, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore, Singapore., See TY; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR)Immunos, Singapore, Singapore., Sari IN; Laboratory of NF-κB Signalling, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore, Singapore., Chan JW; Laboratory of NF-κB Signalling, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore, Singapore., Majee P; Laboratory of NF-κB Signalling, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore, Singapore., Balachander A; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR)Immunos, Singapore, Singapore., Yu J; Department of Microbiology and Immunology, Immunology Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Immunology Programme, Life Science Institute, National University of Singapore, Singapore, Singapore., Wong AH; Laboratory of NF-κB Signalling, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore, Singapore., Mok MMH; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore., Foo SH; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR)Immunos, Singapore, Singapore., Tang WL; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR)Immunos, Singapore, Singapore., Ang N; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR)Immunos, Singapore, Singapore., Tan I; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR)Immunos, Singapore, Singapore., Peng YF; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore., Jaynes P; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore., Xu S; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR)Immunos, Singapore, Singapore.; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Ghosh G; Department of Chemistry & Biochemistry, University of California, San Diego, La Jolla, CA, USA., Shahabi S; Department of Chemistry & Biochemistry, University of California, San Diego, La Jolla, CA, USA., Jeyasekharan AD; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.; NUS Centre for Cancer Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Department of Haematology-Oncology, National University Hospital, Singapore, Singapore., Ikawa M; Research Institute for Microbial Diseases, Osaka University, Osaka, Japan., Zhang Y; Department of Microbiology and Immunology, Immunology Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Immunology Programme, Life Science Institute, National University of Singapore, Singapore, Singapore., Howland SW; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR)Immunos, Singapore, Singapore., Lau MC; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR)Immunos, Singapore, Singapore.; Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Wang VY; Faculty of Health Sciences, University of Macau, Taipa, China.; MoE Frontiers Science Center for Precision Oncology, University of Macau, Taipa, China.; Cancer Centre, Faculty of Health Sciences, University of Macau, Taipa, China., Lam KP; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR)Immunos, Singapore, Singapore. lamkp@a-star.edu.sg.; Department of Microbiology and Immunology, Immunology Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. lamkp@a-star.edu.sg.; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore. lamkp@a-star.edu.sg., Tergaonkar V; Laboratory of NF-κB Signalling, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore, Singapore. vinayt@imcb.a-star.edu.sg.; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. vinayt@imcb.a-star.edu.sg.
Source: Nature immunology [Nat Immunol] 2025 Sep; Vol. 26 (9), pp. 1553-1566. Date of Electronic Publication: 2025 Jul 25.
Publication Type: Journal Article
Journal Info: Publisher: Nature America Inc Country of Publication: United States NLM ID: 100941354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1529-2916 (Electronic) Linking ISSN: 15292908 NLM ISO Abbreviation: Nat Immunol Subsets: MEDLINE
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  Data: The transcription complex p52-ETS1 is essential for germinal center formation.
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  Data: <searchLink fieldCode="AU" term="%22Morgan+D%22">Morgan D</searchLink>; Laboratory of NF-κB Signalling, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore, Singapore.; Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Zhang+B%22">Zhang B</searchLink>; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR)Immunos, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Fidan+K%22">Fidan K</searchLink>; Laboratory of NF-κB Signalling, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Pan+W%22">Pan W</searchLink>; Faculty of Health Sciences, University of Macau, Taipa, China.<br /><searchLink fieldCode="AU" term="%22Vaiyapuri+TS%22">Vaiyapuri TS</searchLink>; Laboratory of NF-κB Signalling, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Raju+A%22">Raju A</searchLink>; Laboratory of NF-κB Signalling, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Hei+D%22">Hei D</searchLink>; Laboratory of NF-κB Signalling, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22See+TY%22">See TY</searchLink>; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR)Immunos, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Sari+IN%22">Sari IN</searchLink>; Laboratory of NF-κB Signalling, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Chan+JW%22">Chan JW</searchLink>; Laboratory of NF-κB Signalling, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Majee+P%22">Majee P</searchLink>; Laboratory of NF-κB Signalling, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Balachander+A%22">Balachander A</searchLink>; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR)Immunos, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Yu+J%22">Yu J</searchLink>; Department of Microbiology and Immunology, Immunology Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Immunology Programme, Life Science Institute, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Wong+AH%22">Wong AH</searchLink>; Laboratory of NF-κB Signalling, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Mok+MMH%22">Mok MMH</searchLink>; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Foo+SH%22">Foo SH</searchLink>; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR)Immunos, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Tang+WL%22">Tang WL</searchLink>; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR)Immunos, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Ang+N%22">Ang N</searchLink>; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR)Immunos, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Tan+I%22">Tan I</searchLink>; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR)Immunos, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Peng+YF%22">Peng YF</searchLink>; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Jaynes+P%22">Jaynes P</searchLink>; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Xu+S%22">Xu S</searchLink>; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR)Immunos, Singapore, Singapore.; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Ghosh+G%22">Ghosh G</searchLink>; Department of Chemistry & Biochemistry, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Shahabi+S%22">Shahabi S</searchLink>; Department of Chemistry & Biochemistry, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Jeyasekharan+AD%22">Jeyasekharan AD</searchLink>; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.; NUS Centre for Cancer Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Department of Haematology-Oncology, National University Hospital, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Ikawa+M%22">Ikawa M</searchLink>; Research Institute for Microbial Diseases, Osaka University, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Department of Microbiology and Immunology, Immunology Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Immunology Programme, Life Science Institute, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Howland+SW%22">Howland SW</searchLink>; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR)Immunos, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Lau+MC%22">Lau MC</searchLink>; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR)Immunos, Singapore, Singapore.; Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Wang+VY%22">Wang VY</searchLink>; Faculty of Health Sciences, University of Macau, Taipa, China.; MoE Frontiers Science Center for Precision Oncology, University of Macau, Taipa, China.; Cancer Centre, Faculty of Health Sciences, University of Macau, Taipa, China.<br /><searchLink fieldCode="AU" term="%22Lam+KP%22">Lam KP</searchLink>; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR)Immunos, Singapore, Singapore. lamkp@a-star.edu.sg.; Department of Microbiology and Immunology, Immunology Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. lamkp@a-star.edu.sg.; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore. lamkp@a-star.edu.sg.<br /><searchLink fieldCode="AU" term="%22Tergaonkar+V%22">Tergaonkar V</searchLink>; Laboratory of NF-κB Signalling, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore, Singapore. vinayt@imcb.a-star.edu.sg.; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. vinayt@imcb.a-star.edu.sg.
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