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Structured vs Self-Guided Multidomain Lifestyle Interventions for Global Cognitive Function: The US POINTER Randomized Clinical Trial.

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Title: Structured vs Self-Guided Multidomain Lifestyle Interventions for Global Cognitive Function: The US POINTER Randomized Clinical Trial.
Authors: Baker LD; Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina., Espeland MA; Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina., Whitmer RA; Department of Public Health Sciences, University of California, Davis, Sacramento., Snyder HM; Division of Medical and Scientific Relations, Alzheimer's Association, Chicago, Illinois., Leng X; Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina., Lovato L; Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina., Papp KV; Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts.; Department of Neurology, Massachusetts General Hospital, Boston.; Department of Neurology, Harvard Medical School, Boston, Massachusetts., Yu M; Department of Neurology, Baylor College of Medicine, Houston, Texas., Kivipelto M; Division of Clinical Geriatrics, Center for Alzheimer Research, Karolinska Institute, Stockholm, Sweden.; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.; School of Public Health, Ageing Epidemiology Research Unit, Imperial College London, London, United Kingdom., Alexander AS; Kelsey Research Foundation, Houston, Texas., Antkowiak S; Rhode Island Chapter, Alzheimer's Association, Providence., Cleveland M; Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina., Day C; Northern California and Northern Nevada Chapter, Alzheimer's Association, San Jose., Elbein R; Houston and Southeast Texas Chapter, Alzheimer's Association, Houston., Tomaszewski Farias S; Department of Neurology, University of California, Davis, Sacramento., Felton D; Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina., Garcia KR; Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina., Gitelman DR; Advocate Memory Center and the Advocate Aurora Research Institute, Advocate Aurora Health, Downers Grove, Illinois., Graef S; Department of Clinical Nutrition, Rush University Medical Center, Chicago, Illinois., Howard M; Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina., Katula J; Department of Health and Exercise Science, Wake Forest University, Winston-Salem, North Carolina., Lambert K; Western Carolina Chapter, Alzheimer's Association, Charlotte, North Carolina., Matongo O; Illinois Chapter, Alzheimer's Association, Chicago., McDonald AM; Houston and Southeast Texas Chapter, Alzheimer's Association, Houston., Pavlik V; Department of Neurology, Baylor College of Medicine, Houston, Texas., Raman R; Alzheimer's Therapeutic Research Institute, University of Southern California, San Diego., Salloway S; Memory and Aging Program, Butler Hospital, and Warren Alpert Medical School of Brown University, Providence, Rhode Island.; Department of Psychiatry and Human Behavior, School of Medicine, Brown University, Providence, Rhode Island., Tangney C; Departments of Clinical Nutrition and Family and Preventive Medicine, Rush University Medical Center, Chicago, Illinois., Ventrelle J; Departments of Clinical Nutrition and Family and Preventive Medicine, Rush University Medical Center, Chicago, Illinois., Wilmoth S; Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina., Willliams BJ; Department of Neurology, Wake Forest University School of Medicine, Winston-Salem, North Carolina., Wing R; Memory and Aging Program, Butler Hospital, and Warren Alpert Medical School of Brown University, Providence, Rhode Island.; The Miriam Hospital, Providence, Rhode Island., Woolard N; Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina., Carrillo MC; Division of Medical and Scientific Relations, Alzheimer's Association, Chicago, Illinois.
Source: JAMA [JAMA] 2025 Aug 26; Vol. 334 (8), pp. 681-691.
Publication Type: Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Medical Association Country of Publication: United States NLM ID: 7501160 Publication Model: Print Cited Medium: Internet ISSN: 1538-3598 (Electronic) Linking ISSN: 00987484 NLM ISO Abbreviation: JAMA Subsets: MEDLINE
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  Data: Structured vs Self-Guided Multidomain Lifestyle Interventions for Global Cognitive Function: The US POINTER Randomized Clinical Trial.
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  Data: <searchLink fieldCode="AU" term="%22Baker+LD%22">Baker LD</searchLink>; Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina.<br /><searchLink fieldCode="AU" term="%22Espeland+MA%22">Espeland MA</searchLink>; Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina.<br /><searchLink fieldCode="AU" term="%22Whitmer+RA%22">Whitmer RA</searchLink>; Department of Public Health Sciences, University of California, Davis, Sacramento.<br /><searchLink fieldCode="AU" term="%22Snyder+HM%22">Snyder HM</searchLink>; Division of Medical and Scientific Relations, Alzheimer's Association, Chicago, Illinois.<br /><searchLink fieldCode="AU" term="%22Leng+X%22">Leng X</searchLink>; Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina.<br /><searchLink fieldCode="AU" term="%22Lovato+L%22">Lovato L</searchLink>; Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina.<br /><searchLink fieldCode="AU" term="%22Papp+KV%22">Papp KV</searchLink>; Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts.; Department of Neurology, Massachusetts General Hospital, Boston.; Department of Neurology, Harvard Medical School, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Yu+M%22">Yu M</searchLink>; Department of Neurology, Baylor College of Medicine, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Kivipelto+M%22">Kivipelto M</searchLink>; Division of Clinical Geriatrics, Center for Alzheimer Research, Karolinska Institute, Stockholm, Sweden.; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.; School of Public Health, Ageing Epidemiology Research Unit, Imperial College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Alexander+AS%22">Alexander AS</searchLink>; Kelsey Research Foundation, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Antkowiak+S%22">Antkowiak S</searchLink>; Rhode Island Chapter, Alzheimer's Association, Providence.<br /><searchLink fieldCode="AU" term="%22Cleveland+M%22">Cleveland M</searchLink>; Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina.<br /><searchLink fieldCode="AU" term="%22Day+C%22">Day C</searchLink>; Northern California and Northern Nevada Chapter, Alzheimer's Association, San Jose.<br /><searchLink fieldCode="AU" term="%22Elbein+R%22">Elbein R</searchLink>; Houston and Southeast Texas Chapter, Alzheimer's Association, Houston.<br /><searchLink fieldCode="AU" term="%22Tomaszewski+Farias+S%22">Tomaszewski Farias S</searchLink>; Department of Neurology, University of California, Davis, Sacramento.<br /><searchLink fieldCode="AU" term="%22Felton+D%22">Felton D</searchLink>; Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina.<br /><searchLink fieldCode="AU" term="%22Garcia+KR%22">Garcia KR</searchLink>; Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina.<br /><searchLink fieldCode="AU" term="%22Gitelman+DR%22">Gitelman DR</searchLink>; Advocate Memory Center and the Advocate Aurora Research Institute, Advocate Aurora Health, Downers Grove, Illinois.<br /><searchLink fieldCode="AU" term="%22Graef+S%22">Graef S</searchLink>; Department of Clinical Nutrition, Rush University Medical Center, Chicago, Illinois.<br /><searchLink fieldCode="AU" term="%22Howard+M%22">Howard M</searchLink>; Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina.<br /><searchLink fieldCode="AU" term="%22Katula+J%22">Katula J</searchLink>; Department of Health and Exercise Science, Wake Forest University, Winston-Salem, North Carolina.<br /><searchLink fieldCode="AU" term="%22Lambert+K%22">Lambert K</searchLink>; Western Carolina Chapter, Alzheimer's Association, Charlotte, North Carolina.<br /><searchLink fieldCode="AU" term="%22Matongo+O%22">Matongo O</searchLink>; Illinois Chapter, Alzheimer's Association, Chicago.<br /><searchLink fieldCode="AU" term="%22McDonald+AM%22">McDonald AM</searchLink>; Houston and Southeast Texas Chapter, Alzheimer's Association, Houston.<br /><searchLink fieldCode="AU" term="%22Pavlik+V%22">Pavlik V</searchLink>; Department of Neurology, Baylor College of Medicine, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Raman+R%22">Raman R</searchLink>; Alzheimer's Therapeutic Research Institute, University of Southern California, San Diego.<br /><searchLink fieldCode="AU" term="%22Salloway+S%22">Salloway S</searchLink>; Memory and Aging Program, Butler Hospital, and Warren Alpert Medical School of Brown University, Providence, Rhode Island.; Department of Psychiatry and Human Behavior, School of Medicine, Brown University, Providence, Rhode Island.<br /><searchLink fieldCode="AU" term="%22Tangney+C%22">Tangney C</searchLink>; Departments of Clinical Nutrition and Family and Preventive Medicine, Rush University Medical Center, Chicago, Illinois.<br /><searchLink fieldCode="AU" term="%22Ventrelle+J%22">Ventrelle J</searchLink>; Departments of Clinical Nutrition and Family and Preventive Medicine, Rush University Medical Center, Chicago, Illinois.<br /><searchLink fieldCode="AU" term="%22Wilmoth+S%22">Wilmoth S</searchLink>; Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina.<br /><searchLink fieldCode="AU" term="%22Willliams+BJ%22">Willliams BJ</searchLink>; Department of Neurology, Wake Forest University School of Medicine, Winston-Salem, North Carolina.<br /><searchLink fieldCode="AU" term="%22Wing+R%22">Wing R</searchLink>; Memory and Aging Program, Butler Hospital, and Warren Alpert Medical School of Brown University, Providence, Rhode Island.; The Miriam Hospital, Providence, Rhode Island.<br /><searchLink fieldCode="AU" term="%22Woolard+N%22">Woolard N</searchLink>; Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina.<br /><searchLink fieldCode="AU" term="%22Carrillo+MC%22">Carrillo MC</searchLink>; Division of Medical and Scientific Relations, Alzheimer's Association, Chicago, Illinois.
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