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Comparative Effectiveness of Tofacitinib vs Upadacitinib for the Treatment of Acute Severe Ulcerative Colitis.

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Title: Comparative Effectiveness of Tofacitinib vs Upadacitinib for the Treatment of Acute Severe Ulcerative Colitis.
Authors: Honap S; School of Immunology and Microbial Sciences, King's College London, United Kingdom; Department of Gastroenterology, St George's University Hospitals NHS Foundation Trust, London, United Kingdom. Electronic address: sailish.honap@kcl.ac.uk., St-Pierre J; Division of Gastroenterology and Hepatology, Department of Medicine, University of Calgary, Calgary, Alberta, Canada., Colwill M; Department of Gastroenterology, St George's University Hospitals NHS Foundation Trust, London, United Kingdom; Institute of Infection and Immunity, City St George's, University of London, London, United Kingdom., Patel K; Department of Gastroenterology, St George's University Hospitals NHS Foundation Trust, London, United Kingdom., Le Berre C; CHU Nantes, Institut des Maladies de l'Appareil Digestif, CIC Inserm 1413, Université de Nantes, Nantes, France., Caron B; Université de Lorraine, CHRU, Inserm, NGERE, Nancy, France., Nogami A; Center for Advanced IBD Research and Treatment, Kitasato University Kitasato Institute Hospital, Tokyo, Japan., Kobayashi T; Center for Advanced IBD Research and Treatment, Kitasato University Kitasato Institute Hospital, Tokyo, Japan., Altwegg R; Department of Hepatogastroenterology, CHU St Eloi Montpellier, Montpellier, France., Laharie D; CHU de Bordeaux, Hôpital Haut-Lévêque, Service d'Hépato-gastroentérologie et Oncologie Digestive, Université de Bordeaux, Bordeaux, France., Hebuterne X; Department of Gastroenterology and Clinical Nutrition, CHU of Nice and University Côte d'Azur, Nice, France., Nachury M; Université Lille, Inserm, CHU Lille, U1286 - INFINITE - Institute for Translational Research in Inflammation, Lille, France., Roblin X; Department of Gastroenterology, University Hospital of Saint-Etienne, Saint-Etienne, France., Uzzan M; Department of Gastroenterology, Hopital Henri Mondor, APHP, Créteil, France., Kotze PG; Colorectal Surgery Unit, Pontificia Universidade Católica do Paraná, Curitiba, Brazil., Lukáš M; Clinical and Research Center for Inflammatory Bowel Diseases, ISCARE Clinical Centre, Prague, Czech Republic., Vieujean S; Department of Gastroenterology, St George's University Hospitals NHS Foundation Trust, London, United Kingdom; Hepato-Gastroenterology and Digestive Oncology, University Hospital CHU of Liège, Liège, Belgium., D'Amico F; Department of Gastroenterology and Endoscopy, IRCCS San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy., Albshesh A; Division of Gastroenterology, Sheba Medical Center, Ramat Gan, Israel., Guillo L; Department of Gastroenterology, University Hospital of Marseille Nord, University of Aix-Marseille, Marseille, France., Fumery M; Hepato-Gastro-Enterology Department, CHU Amiens Picardie, and Peritox UMIR I-O1, Université de Picardie Jules Verne, Amiens, France., Nancey S; Department of Gastroenterology, Lyon Sud Hospital, Hospices Civils de Lyon and INSERM U1111, CIRI, Lyon, France., Ye BD; Department of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea., Bergemalm D; Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden., Halfvarson J; Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden., Buisson A; Gastroenterology Unit, Clermont Ferrand University Hospital, Clermont Ferrand, France., Karmiris K; Department of Gastroenterology, Venizeleio General Hospital, Heraklion, Greece., Rubin DT; University of Chicago Medicine Inflammatory Bowel Disease Center, Chicago, Illinois., Vicaut E; Assistance Publique-Hopitaux de Paris, Lariboisiere Fernand-Widal Hospital, Paris, France., Peyrin-Biroulet L; Department of Gastroenterology, CHRU Nancy, INSERM NGERE, Université de Lorraine, Vandœuvre-lès-Nancy, France.
Corporate Authors: ATTRACT Study Group
Source: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association [Clin Gastroenterol Hepatol] 2026 Mar; Vol. 24 (3), pp. 784-793. Date of Electronic Publication: 2025 Jul 26.
Publication Type: Journal Article; Multicenter Study; Comparative Study
Journal Info: Publisher: W.B. Saunders for the American Gastroenterological Association Country of Publication: United States NLM ID: 101160775 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1542-7714 (Electronic) Linking ISSN: 15423565 NLM ISO Abbreviation: Clin Gastroenterol Hepatol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Comparative Effectiveness of Tofacitinib vs Upadacitinib for the Treatment of Acute Severe Ulcerative Colitis.
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  Data: <searchLink fieldCode="AU" term="%22Honap+S%22">Honap S</searchLink>; School of Immunology and Microbial Sciences, King's College London, United Kingdom; Department of Gastroenterology, St George's University Hospitals NHS Foundation Trust, London, United Kingdom. Electronic address: sailish.honap@kcl.ac.uk.<br /><searchLink fieldCode="AU" term="%22St-Pierre+J%22">St-Pierre J</searchLink>; Division of Gastroenterology and Hepatology, Department of Medicine, University of Calgary, Calgary, Alberta, Canada.<br /><searchLink fieldCode="AU" term="%22Colwill+M%22">Colwill M</searchLink>; Department of Gastroenterology, St George's University Hospitals NHS Foundation Trust, London, United Kingdom; Institute of Infection and Immunity, City St George's, University of London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Patel+K%22">Patel K</searchLink>; Department of Gastroenterology, St George's University Hospitals NHS Foundation Trust, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Le+Berre+C%22">Le Berre C</searchLink>; CHU Nantes, Institut des Maladies de l'Appareil Digestif, CIC Inserm 1413, Université de Nantes, Nantes, France.<br /><searchLink fieldCode="AU" term="%22Caron+B%22">Caron B</searchLink>; Université de Lorraine, CHRU, Inserm, NGERE, Nancy, France.<br /><searchLink fieldCode="AU" term="%22Nogami+A%22">Nogami A</searchLink>; Center for Advanced IBD Research and Treatment, Kitasato University Kitasato Institute Hospital, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Kobayashi+T%22">Kobayashi T</searchLink>; Center for Advanced IBD Research and Treatment, Kitasato University Kitasato Institute Hospital, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Altwegg+R%22">Altwegg R</searchLink>; Department of Hepatogastroenterology, CHU St Eloi Montpellier, Montpellier, France.<br /><searchLink fieldCode="AU" term="%22Laharie+D%22">Laharie D</searchLink>; CHU de Bordeaux, Hôpital Haut-Lévêque, Service d'Hépato-gastroentérologie et Oncologie Digestive, Université de Bordeaux, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Hebuterne+X%22">Hebuterne X</searchLink>; Department of Gastroenterology and Clinical Nutrition, CHU of Nice and University Côte d'Azur, Nice, France.<br /><searchLink fieldCode="AU" term="%22Nachury+M%22">Nachury M</searchLink>; Université Lille, Inserm, CHU Lille, U1286 - INFINITE - Institute for Translational Research in Inflammation, Lille, France.<br /><searchLink fieldCode="AU" term="%22Roblin+X%22">Roblin X</searchLink>; Department of Gastroenterology, University Hospital of Saint-Etienne, Saint-Etienne, France.<br /><searchLink fieldCode="AU" term="%22Uzzan+M%22">Uzzan M</searchLink>; Department of Gastroenterology, Hopital Henri Mondor, APHP, Créteil, France.<br /><searchLink fieldCode="AU" term="%22Kotze+PG%22">Kotze PG</searchLink>; Colorectal Surgery Unit, Pontificia Universidade Católica do Paraná, Curitiba, Brazil.<br /><searchLink fieldCode="AU" term="%22Lukáš+M%22">Lukáš M</searchLink>; Clinical and Research Center for Inflammatory Bowel Diseases, ISCARE Clinical Centre, Prague, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Vieujean+S%22">Vieujean S</searchLink>; Department of Gastroenterology, St George's University Hospitals NHS Foundation Trust, London, United Kingdom; Hepato-Gastroenterology and Digestive Oncology, University Hospital CHU of Liège, Liège, Belgium.<br /><searchLink fieldCode="AU" term="%22D'Amico+F%22">D'Amico F</searchLink>; Department of Gastroenterology and Endoscopy, IRCCS San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Albshesh+A%22">Albshesh A</searchLink>; Division of Gastroenterology, Sheba Medical Center, Ramat Gan, Israel.<br /><searchLink fieldCode="AU" term="%22Guillo+L%22">Guillo L</searchLink>; Department of Gastroenterology, University Hospital of Marseille Nord, University of Aix-Marseille, Marseille, France.<br /><searchLink fieldCode="AU" term="%22Fumery+M%22">Fumery M</searchLink>; Hepato-Gastro-Enterology Department, CHU Amiens Picardie, and Peritox UMIR I-O1, Université de Picardie Jules Verne, Amiens, France.<br /><searchLink fieldCode="AU" term="%22Nancey+S%22">Nancey S</searchLink>; Department of Gastroenterology, Lyon Sud Hospital, Hospices Civils de Lyon and INSERM U1111, CIRI, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Ye+BD%22">Ye BD</searchLink>; Department of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.<br /><searchLink fieldCode="AU" term="%22Bergemalm+D%22">Bergemalm D</searchLink>; Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.<br /><searchLink fieldCode="AU" term="%22Halfvarson+J%22">Halfvarson J</searchLink>; Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.<br /><searchLink fieldCode="AU" term="%22Buisson+A%22">Buisson A</searchLink>; Gastroenterology Unit, Clermont Ferrand University Hospital, Clermont Ferrand, France.<br /><searchLink fieldCode="AU" term="%22Karmiris+K%22">Karmiris K</searchLink>; Department of Gastroenterology, Venizeleio General Hospital, Heraklion, Greece.<br /><searchLink fieldCode="AU" term="%22Rubin+DT%22">Rubin DT</searchLink>; University of Chicago Medicine Inflammatory Bowel Disease Center, Chicago, Illinois.<br /><searchLink fieldCode="AU" term="%22Vicaut+E%22">Vicaut E</searchLink>; Assistance Publique-Hopitaux de Paris, Lariboisiere Fernand-Widal Hospital, Paris, France.<br /><searchLink fieldCode="AU" term="%22Peyrin-Biroulet+L%22">Peyrin-Biroulet L</searchLink>; Department of Gastroenterology, CHRU Nancy, INSERM NGERE, Université de Lorraine, Vandœuvre-lès-Nancy, France.
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