Inhibition of HDAC6 alters fumarate hydratase activity and mitochondrial structure.

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Title: Inhibition of HDAC6 alters fumarate hydratase activity and mitochondrial structure.
Authors: Roe A; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland., Dowling CM; Department of Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland., D'Arcy C; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland., Alencar Rodrigues D; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland., Wang Y; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland., Hiller M; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland., Keogh C; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland., Hollinshead KER; Department of Radiation Oncology, Laura and Isaac Perlmutter Cancer Center, New York University Langone Medical Center, New York, NY, USA., Garre M; Super Resolution Imaging Consortium (SRIC), Department of Chemistry, Royal College of Surgeons in Ireland, Dublin, Ireland., Cavanagh B; Cellular & Molecular Imaging Core, Royal College of Surgeons in Ireland, Dublin, Ireland., Wynne K; Systems Biology Ireland, School of Medicine, University College Dublin, Belfield, Dublin, Ireland.; UCD Conway Institute, University College Dublin, Dublin, Ireland., Liu T; College of Future Technology, Peking University, Beijing, China., Chen Z; College of Future Technology, Peking University, Beijing, China., Kerr E; Patrick G Johnson Centre for Cancer Research, Queen's University, Belfast, N, Ireland., McIlroy M; Department of Surgery, Royal College of Surgeons in Ireland, Dublin, Ireland., H M Prehn J; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland., Schoen I; School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland., Chonghaile TN; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland. tnichonghaile@rcsi.ie.
Source: Nature communications [Nat Commun] 2025 Jul 28; Vol. 16 (1), pp. 6923. Date of Electronic Publication: 2025 Jul 28.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2041-1723
DOI:10.1038/s41467-025-61897-6