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Inhibition of HDAC6 alters fumarate hydratase activity and mitochondrial structure.

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Title: Inhibition of HDAC6 alters fumarate hydratase activity and mitochondrial structure.
Authors: Roe A; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland., Dowling CM; Department of Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland., D'Arcy C; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland., Alencar Rodrigues D; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland., Wang Y; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland., Hiller M; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland., Keogh C; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland., Hollinshead KER; Department of Radiation Oncology, Laura and Isaac Perlmutter Cancer Center, New York University Langone Medical Center, New York, NY, USA., Garre M; Super Resolution Imaging Consortium (SRIC), Department of Chemistry, Royal College of Surgeons in Ireland, Dublin, Ireland., Cavanagh B; Cellular & Molecular Imaging Core, Royal College of Surgeons in Ireland, Dublin, Ireland., Wynne K; Systems Biology Ireland, School of Medicine, University College Dublin, Belfield, Dublin, Ireland.; UCD Conway Institute, University College Dublin, Dublin, Ireland., Liu T; College of Future Technology, Peking University, Beijing, China., Chen Z; College of Future Technology, Peking University, Beijing, China., Kerr E; Patrick G Johnson Centre for Cancer Research, Queen's University, Belfast, N, Ireland., McIlroy M; Department of Surgery, Royal College of Surgeons in Ireland, Dublin, Ireland., H M Prehn J; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland., Schoen I; School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland., Chonghaile TN; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland. tnichonghaile@rcsi.ie.
Source: Nature communications [Nat Commun] 2025 Jul 28; Vol. 16 (1), pp. 6923. Date of Electronic Publication: 2025 Jul 28.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Roe+A%22">Roe A</searchLink>; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Dowling+CM%22">Dowling CM</searchLink>; Department of Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22D'Arcy+C%22">D'Arcy C</searchLink>; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Alencar+Rodrigues+D%22">Alencar Rodrigues D</searchLink>; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Hiller+M%22">Hiller M</searchLink>; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Keogh+C%22">Keogh C</searchLink>; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Hollinshead+KER%22">Hollinshead KER</searchLink>; Department of Radiation Oncology, Laura and Isaac Perlmutter Cancer Center, New York University Langone Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Garre+M%22">Garre M</searchLink>; Super Resolution Imaging Consortium (SRIC), Department of Chemistry, Royal College of Surgeons in Ireland, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Cavanagh+B%22">Cavanagh B</searchLink>; Cellular & Molecular Imaging Core, Royal College of Surgeons in Ireland, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Wynne+K%22">Wynne K</searchLink>; Systems Biology Ireland, School of Medicine, University College Dublin, Belfield, Dublin, Ireland.; UCD Conway Institute, University College Dublin, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Liu+T%22">Liu T</searchLink>; College of Future Technology, Peking University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Chen+Z%22">Chen Z</searchLink>; College of Future Technology, Peking University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Kerr+E%22">Kerr E</searchLink>; Patrick G Johnson Centre for Cancer Research, Queen's University, Belfast, N, Ireland.<br /><searchLink fieldCode="AU" term="%22McIlroy+M%22">McIlroy M</searchLink>; Department of Surgery, Royal College of Surgeons in Ireland, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22H+M+Prehn+J%22">H M Prehn J</searchLink>; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Schoen+I%22">Schoen I</searchLink>; School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Chonghaile+TN%22">Chonghaile TN</searchLink>; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland. tnichonghaile@rcsi.ie.
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