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CD40 blockade hampers IgG class-switch while enhancing Granzyme B production by transitional B cells.

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Title: CD40 blockade hampers IgG class-switch while enhancing Granzyme B production by transitional B cells.
Authors: Werner F; Department of Paediatrics and Adolescent Medicine, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany., Wittner J; Division of Molecular Immunology, Department of Medicine III, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany., Lehmann CHK; Department of Paediatrics and Adolescent Medicine, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.; Profile Center Immunomedicine (I-MED), Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.; Deutsches Zentrum Immuntherapie, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany., Wahlbuhl M; Department of Paediatrics and Adolescent Medicine, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany., Allabauer I; Department of Paediatrics and Adolescent Medicine, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany., Hoffmann A; Division of Molecular Immunology, Department of Medicine III, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany., Schnell A; Department of Paediatrics and Adolescent Medicine, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany., Krickau T; Department of Paediatrics and Adolescent Medicine, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.; Profile Center Immunomedicine (I-MED), Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.; Deutsches Zentrum Immuntherapie, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany., Hackstein H; Division of Transfusion Medicine, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany., Dietel-Schor B; Department of Medicine II, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany., Rush JS; Novartis Institutes for BioMedical Research Autoimmunity, Transplantation, Inflammation, Basel, Switzerland., Regnier CH; Novartis Institutes for BioMedical Research Autoimmunity, Transplantation, Inflammation, Basel, Switzerland., Jäck HM; Division of Molecular Immunology, Department of Medicine III, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany., Woelfle J; Department of Paediatrics and Adolescent Medicine, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany., Schuh W; Division of Molecular Immunology, Department of Medicine III, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany., Hoerning A; Department of Paediatrics and Adolescent Medicine, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.; Profile Center Immunomedicine (I-MED), Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.; Deutsches Zentrum Immuntherapie, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.
Source: Clinical and experimental immunology [Clin Exp Immunol] 2025 Jan 21; Vol. 219 (1).
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0057202 Publication Model: Print Cited Medium: Internet ISSN: 1365-2249 (Electronic) Linking ISSN: 00099104 NLM ISO Abbreviation: Clin Exp Immunol Subsets: MEDLINE
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  Data: CD40 blockade hampers IgG class-switch while enhancing Granzyme B production by transitional B cells.
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  Data: <searchLink fieldCode="AU" term="%22Werner+F%22">Werner F</searchLink>; Department of Paediatrics and Adolescent Medicine, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Wittner+J%22">Wittner J</searchLink>; Division of Molecular Immunology, Department of Medicine III, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Lehmann+CHK%22">Lehmann CHK</searchLink>; Department of Paediatrics and Adolescent Medicine, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.; Profile Center Immunomedicine (I-MED), Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.; Deutsches Zentrum Immuntherapie, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Wahlbuhl+M%22">Wahlbuhl M</searchLink>; Department of Paediatrics and Adolescent Medicine, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Allabauer+I%22">Allabauer I</searchLink>; Department of Paediatrics and Adolescent Medicine, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Hoffmann+A%22">Hoffmann A</searchLink>; Division of Molecular Immunology, Department of Medicine III, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Schnell+A%22">Schnell A</searchLink>; Department of Paediatrics and Adolescent Medicine, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Krickau+T%22">Krickau T</searchLink>; Department of Paediatrics and Adolescent Medicine, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.; Profile Center Immunomedicine (I-MED), Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.; Deutsches Zentrum Immuntherapie, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Hackstein+H%22">Hackstein H</searchLink>; Division of Transfusion Medicine, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Dietel-Schor+B%22">Dietel-Schor B</searchLink>; Department of Medicine II, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Rush+JS%22">Rush JS</searchLink>; Novartis Institutes for BioMedical Research Autoimmunity, Transplantation, Inflammation, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Regnier+CH%22">Regnier CH</searchLink>; Novartis Institutes for BioMedical Research Autoimmunity, Transplantation, Inflammation, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Jäck+HM%22">Jäck HM</searchLink>; Division of Molecular Immunology, Department of Medicine III, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Woelfle+J%22">Woelfle J</searchLink>; Department of Paediatrics and Adolescent Medicine, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Schuh+W%22">Schuh W</searchLink>; Division of Molecular Immunology, Department of Medicine III, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Hoerning+A%22">Hoerning A</searchLink>; Department of Paediatrics and Adolescent Medicine, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.; Profile Center Immunomedicine (I-MED), Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.; Deutsches Zentrum Immuntherapie, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.
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