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Autocrine interferon poisoning mediates ADAR1-dependent synthetic lethality in BRCA1/2-mutant cancers.

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Title: Autocrine interferon poisoning mediates ADAR1-dependent synthetic lethality in BRCA1/2-mutant cancers.
Authors: Chabanon RM; The ERC (Epi)Genetic Vulnerabilities in Solid Tumors and Sarcoma Laboratory, Inserm Unit UMR981, Gustave Roussy, Villejuif, France. roman.chabanon@gustaveroussy.fr.; Faculté de Médecine, Université Paris-Saclay, Le Kremlin Bicêtre, France. roman.chabanon@gustaveroussy.fr.; The CRUK Gene Function Laboratory, The Institute of Cancer Research, London, UK. roman.chabanon@gustaveroussy.fr.; The Breast Cancer Now Toby Robins Breast Cancer Research Centre, London, UK. roman.chabanon@gustaveroussy.fr., Shcherbakova L; The ERC (Epi)Genetic Vulnerabilities in Solid Tumors and Sarcoma Laboratory, Inserm Unit UMR981, Gustave Roussy, Villejuif, France.; Faculté de Médecine, Université Paris-Saclay, Le Kremlin Bicêtre, France., Lacroix-Triki M; Molecular Characterization of Breast and Gynecological Cancers Laboratory, Inserm Unit UMR981, Gustave Roussy, Villejuif, France.; Department of Pathology, Gustave Roussy, Villejuif, France., Aglave M; Bioinformatics (BiGR) Platform, Gustave Roussy, Villejuif, France., Zeghondy J; Department of Medical Oncology, Gustave Roussy, Villejuif, France., Kriaa V; Inserm Unit U1195, University Paris-Saclay, Le Kremlin Bicêtre, France., Gougé A; The ERC (Epi)Genetic Vulnerabilities in Solid Tumors and Sarcoma Laboratory, Inserm Unit UMR981, Gustave Roussy, Villejuif, France.; Faculté de Médecine, Université Paris-Saclay, Le Kremlin Bicêtre, France., Garrido M; The ERC (Epi)Genetic Vulnerabilities in Solid Tumors and Sarcoma Laboratory, Inserm Unit UMR981, Gustave Roussy, Villejuif, France.; Faculté de Médecine, Université Paris-Saclay, Le Kremlin Bicêtre, France., Edmond E; Experimental and Translational Pathology (PETRA) Platform, AMMICa Unit (CNRS Unit UMS3655, Inserm Unit US23), Gustave Roussy, Villejuif, France., Bigot L; Adaptive Resistance to Anti-Cancer Therapies Laboratory, Inserm Unit UMR981, Gustave Roussy, Villejuif, France., Krastev DB; The CRUK Gene Function Laboratory, The Institute of Cancer Research, London, UK.; The Breast Cancer Now Toby Robins Breast Cancer Research Centre, London, UK., Brough R; The CRUK Gene Function Laboratory, The Institute of Cancer Research, London, UK.; The Breast Cancer Now Toby Robins Breast Cancer Research Centre, London, UK., Pettitt SJ; The CRUK Gene Function Laboratory, The Institute of Cancer Research, London, UK.; The Breast Cancer Now Toby Robins Breast Cancer Research Centre, London, UK., Thomas-Bonafos T; The ERC (Epi)Genetic Vulnerabilities in Solid Tumors and Sarcoma Laboratory, Inserm Unit UMR981, Gustave Roussy, Villejuif, France.; Faculté de Médecine, Université Paris-Saclay, Le Kremlin Bicêtre, France.; Drug Development Department (DITEP), Gustave Roussy, Villejuif, France., Samstein R; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, USA.; Department of Radiation Oncology, Mount Sinai Hospital, New York, USA.; Precision Immunology Institute at Icahn School of Medicine at Mount Sinai, New York, USA., Massard C; Drug Development Department (DITEP), Gustave Roussy, Villejuif, France., Deloger M; Bioinformatics (BiGR) Platform, Gustave Roussy, Villejuif, France., Tutt AN; The Breast Cancer Now Toby Robins Breast Cancer Research Centre, London, UK.; The Breast Cancer Now Research Unit, Guy's Hospital Cancer Centre, King's College London, London, UK., Barlesi F; Department of Medical Oncology, Gustave Roussy, Villejuif, France., Loriot Y; Adaptive Resistance to Anti-Cancer Therapies Laboratory, Inserm Unit UMR981, Gustave Roussy, Villejuif, France.; Drug Development Department (DITEP), Gustave Roussy, Villejuif, France., Delaloge S; Department of Medical Oncology, Gustave Roussy, Villejuif, France., Tawk M; Inserm Unit U1195, University Paris-Saclay, Le Kremlin Bicêtre, France., Degerny C; Inserm Unit U1195, University Paris-Saclay, Le Kremlin Bicêtre, France., Lin YL; The Ligue Contre Le Cancer Maintenance of Genome Integrity during DNA Replication Laboratory, CNRS Unit UMR9002, Institut de Génétique Humaine, Montpellier, France.; Université de Montpellier, Montpellier, France., Pistilli B; Department of Medical Oncology, Gustave Roussy, Villejuif, France., Pasero P; The Ligue Contre Le Cancer Maintenance of Genome Integrity during DNA Replication Laboratory, CNRS Unit UMR9002, Institut de Génétique Humaine, Montpellier, France.; Université de Montpellier, Montpellier, France., Lord CJ; The CRUK Gene Function Laboratory, The Institute of Cancer Research, London, UK. chris.lord@icr.ac.uk.; The Breast Cancer Now Toby Robins Breast Cancer Research Centre, London, UK. chris.lord@icr.ac.uk., Postel-Vinay S; The ERC (Epi)Genetic Vulnerabilities in Solid Tumors and Sarcoma Laboratory, Inserm Unit UMR981, Gustave Roussy, Villejuif, France. sophie.postel-vinay@gustaveroussy.fr.; Faculté de Médecine, Université Paris-Saclay, Le Kremlin Bicêtre, France. sophie.postel-vinay@gustaveroussy.fr.; Drug Development Department (DITEP), Gustave Roussy, Villejuif, France. sophie.postel-vinay@gustaveroussy.fr.; The University College of London Cancer Institute, University College of London, London, UK. sophie.postel-vinay@gustaveroussy.fr.
Source: Nature communications [Nat Commun] 2025 Jul 29; Vol. 16 (1), pp. 6972. Date of Electronic Publication: 2025 Jul 29.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: Autocrine interferon poisoning mediates ADAR1-dependent synthetic lethality in BRCA1/2-mutant cancers.
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The ERC (Epi)Genetic Vulnerabilities in Solid Tumors and Sarcoma Laboratory, Inserm Unit UMR981, Gustave Roussy, Villejuif, France.; Faculté de Médecine, Université Paris-Saclay, Le Kremlin Bicêtre, France.; Drug Development Department (DITEP), Gustave Roussy, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Samstein+R%22">Samstein R</searchLink>; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, USA.; Department of Radiation Oncology, Mount Sinai Hospital, New York, USA.; Precision Immunology Institute at Icahn School of Medicine at Mount Sinai, New York, USA.<br /><searchLink fieldCode="AU" term="%22Massard+C%22">Massard C</searchLink>; Drug Development Department (DITEP), Gustave Roussy, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Deloger+M%22">Deloger M</searchLink>; Bioinformatics (BiGR) Platform, Gustave Roussy, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Tutt+AN%22">Tutt AN</searchLink>; The Breast Cancer Now Toby Robins Breast Cancer Research Centre, London, UK.; 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