Discovery of Cyclopentane-Based Phospholipids as Miltefosine Analogs with Superior Potency and Enhanced Selectivity Against Naegleria fowleri.
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| Title: | Discovery of Cyclopentane-Based Phospholipids as Miltefosine Analogs with Superior Potency and Enhanced Selectivity Against Naegleria fowleri. |
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| Authors: | Hassan AHE; Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.; Department of Pharmacy, College of Pharmacy, Kyung Hee University, 26 Kyungheedae-ro, Seoul 02447, Republic of Korea., Lê HG; Department of Parasitology and Tropical Medicine, Department of Convergence Medical Science, Gyeongsang National University College of Medicine, Jinju 52727, Republic of Korea.; Institute of Health Science, Gyeongsang National University College of Medicine, Jinju 52727, Republic of Korea., Võ TC; Department of Parasitology and Tropical Medicine, Department of Convergence Medical Science, Gyeongsang National University College of Medicine, Jinju 52727, Republic of Korea.; Institute of Health Science, Gyeongsang National University College of Medicine, Jinju 52727, Republic of Korea., Kim M; Department of Fundamental Pharmaceutical Science, Graduate School, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea., No JH; Chemical and Structural Biology of Pathogens, Institut Pasteur Korea, Seongnam-si 13488, Republic of Korea., Aboutaleb MH; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Horus University, New Damietta 34518, Egypt., Sim J; Department of Pharmacy, College of Pharmacy, Kyung Hee University, 26 Kyungheedae-ro, Seoul 02447, Republic of Korea.; Department of Regulatory Science, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea.; Institute of Regulatory Innovation through Science, Kyung Hee University, Seoul 02447, Republic of Korea., Na BK; Department of Parasitology and Tropical Medicine, Department of Convergence Medical Science, Gyeongsang National University College of Medicine, Jinju 52727, Republic of Korea.; Institute of Health Science, Gyeongsang National University College of Medicine, Jinju 52727, Republic of Korea., Lee YS; Department of Pharmacy, College of Pharmacy, Kyung Hee University, 26 Kyungheedae-ro, Seoul 02447, Republic of Korea.; Department of Fundamental Pharmaceutical Science, Graduate School, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea. |
| Source: | Pharmaceuticals (Basel, Switzerland) [Pharmaceuticals (Basel)] 2025 Jun 30; Vol. 18 (7). Date of Electronic Publication: 2025 Jun 30. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101238453 Publication Model: Electronic Cited Medium: Print ISSN: 1424-8247 (Print) Linking ISSN: 14248247 NLM ISO Abbreviation: Pharmaceuticals (Basel) Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
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