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Modulation of immunoglobulin G oligomerization by variable domain glycans: A mechanism to regulate complement activation.

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Title: Modulation of immunoglobulin G oligomerization by variable domain glycans: A mechanism to regulate complement activation.
Authors: Biersteker R; Department of Rheumatology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands., Abendstein L; Department of Cell and Chemical Biology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands., van de Bovenkamp S; Department of Immunology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands., van Dooren HJ; Department of Rheumatology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands., Hamers SMWR; Department of Cell and Chemical Biology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands., Kwekkeboom JC; Department of Rheumatology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands., Stork EM; Department of Rheumatology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands., Drijfhout JW; Department of Immunology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands., Rispens T; Sanquin Research and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam, 1066 CX Amsterdam, The Netherlands.; Amsterdam Institute for Infection and Immunity, 1105 AZ, 1081 HV Amsterdam, The Netherlands., Koeleman CAM; Center for Proteomics and Metabolomics, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands., Wuhrer M; Center for Proteomics and Metabolomics, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands., Trouw LA; Department of Immunology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands., Sharp TH; Department of Cell and Chemical Biology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.; School of Biochemistry, University of Bristol, Bristol BS8 1TD, United Kingdom., Toes REM; Department of Rheumatology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands., Kissel T; Department of Rheumatology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
Source: PNAS nexus [PNAS Nexus] 2025 Jul 16; Vol. 4 (7), pp. pgaf216. Date of Electronic Publication: 2025 Jul 16 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press on behalf of the National Academy of Sciences Country of Publication: England NLM ID: 9918367777906676 Publication Model: eCollection Cited Medium: Internet ISSN: 2752-6542 (Electronic) Linking ISSN: 27526542 NLM ISO Abbreviation: PNAS Nexus Subsets: PubMed not MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Biersteker+R%22">Biersteker R</searchLink>; Department of Rheumatology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Abendstein+L%22">Abendstein L</searchLink>; Department of Cell and Chemical Biology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+de+Bovenkamp+S%22">van de Bovenkamp S</searchLink>; Department of Immunology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Dooren+HJ%22">van Dooren HJ</searchLink>; Department of Rheumatology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Hamers+SMWR%22">Hamers SMWR</searchLink>; Department of Cell and Chemical Biology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Kwekkeboom+JC%22">Kwekkeboom JC</searchLink>; Department of Rheumatology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Stork+EM%22">Stork EM</searchLink>; Department of Rheumatology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Drijfhout+JW%22">Drijfhout JW</searchLink>; Department of Immunology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Rispens+T%22">Rispens T</searchLink>; Sanquin Research and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam, 1066 CX Amsterdam, The Netherlands.; Amsterdam Institute for Infection and Immunity, 1105 AZ, 1081 HV Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Koeleman+CAM%22">Koeleman CAM</searchLink>; Center for Proteomics and Metabolomics, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Wuhrer+M%22">Wuhrer M</searchLink>; Center for Proteomics and Metabolomics, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Trouw+LA%22">Trouw LA</searchLink>; Department of Immunology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Sharp+TH%22">Sharp TH</searchLink>; Department of Cell and Chemical Biology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.; School of Biochemistry, University of Bristol, Bristol BS8 1TD, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Toes+REM%22">Toes REM</searchLink>; Department of Rheumatology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Kissel+T%22">Kissel T</searchLink>; Department of Rheumatology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
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