Anti-Cryptosporidium efficacy of BKI-1708, an inhibitor of Cryptosporidium calcium-dependent protein kinase 1.

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Title: Anti-Cryptosporidium efficacy of BKI-1708, an inhibitor of Cryptosporidium calcium-dependent protein kinase 1.
Authors: Choi R; Department of Medicine, Division of Allergy and Infectious Diseases, Center for Emerging and Re-emerging Infectious Disease (CERID), University of Washington, Seattle, Washington, United States of America., Hulverson MA; Department of Medicine, Division of Allergy and Infectious Diseases, Center for Emerging and Re-emerging Infectious Disease (CERID), University of Washington, Seattle, Washington, United States of America., Schaefer DA; School of Animal and Comparative Biomedical Sciences, College of Agriculture and Life Sciences, University of Arizona, Tucson, Arizona, United States of America., Betzer DP; School of Animal and Comparative Biomedical Sciences, College of Agriculture and Life Sciences, University of Arizona, Tucson, Arizona, United States of America., Riggs MW; School of Animal and Comparative Biomedical Sciences, College of Agriculture and Life Sciences, University of Arizona, Tucson, Arizona, United States of America., Huang W; Department of Biochemistry, University of Washington, Seattle, Washington United States of America., Sun V; Department of Pharmaceutics, University of Washington, Seattle, Washington United States of America., Whitman GR; Department of Medicine, Division of Allergy and Infectious Diseases, Center for Emerging and Re-emerging Infectious Disease (CERID), University of Washington, Seattle, Washington, United States of America., McCloskey MC; Department of Medicine, Division of Allergy and Infectious Diseases, Center for Emerging and Re-emerging Infectious Disease (CERID), University of Washington, Seattle, Washington, United States of America., Marsh K; Research and Development, AbbVie Inc, North Chicago, Illinois, United States of America., Buck WR; Research and Development, AbbVie Inc, North Chicago, Illinois, United States of America., Wagner DS; Research and Development, AbbVie Inc, North Chicago, Illinois, United States of America., Yang J; Research and Development, AbbVie Inc, North Chicago, Illinois, United States of America., Bowman AP; Research and Development, AbbVie Inc, North Chicago, Illinois, United States of America., Ciurlionis R; Research and Development, AbbVie Inc, North Chicago, Illinois, United States of America., Ajiboye J; Cellular, Molecular and Biomedical Sciences Graduate Program, University of Vermont, Burlington, Vermont United States of America.; Institute of Parasitology, Vetsuisse Faculty, University of Bern, Bern, Switzerland., Hemphill A; Institute of Parasitology, Vetsuisse Faculty, University of Bern, Bern, Switzerland., Sigalapalli DK; Department of Biochemistry, University of Washington, Seattle, Washington United States of America., Arnold SLM; Department of Pharmaceutics, University of Washington, Seattle, Washington United States of America., Barrett LK; Department of Medicine, Division of Allergy and Infectious Diseases, Center for Emerging and Re-emerging Infectious Disease (CERID), University of Washington, Seattle, Washington, United States of America., Ojo KK; Department of Medicine, Division of Allergy and Infectious Diseases, Center for Emerging and Re-emerging Infectious Disease (CERID), University of Washington, Seattle, Washington, United States of America., Fan E; Department of Biochemistry, University of Washington, Seattle, Washington United States of America., Van Voorhis WC; Department of Medicine, Division of Allergy and Infectious Diseases, Center for Emerging and Re-emerging Infectious Disease (CERID), University of Washington, Seattle, Washington, United States of America.
Source: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2025 Jul 30; Vol. 19 (7), pp. e0013263. Date of Electronic Publication: 2025 Jul 30 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101291488 Publication Model: eCollection Cited Medium: Internet ISSN: 1935-2735 (Electronic) Linking ISSN: 19352727 NLM ISO Abbreviation: PLoS Negl Trop Dis Subsets: MEDLINE
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  Data: Anti-Cryptosporidium efficacy of BKI-1708, an inhibitor of Cryptosporidium calcium-dependent protein kinase 1.
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  Data: <searchLink fieldCode="AU" term="%22Choi+R%22">Choi R</searchLink>; Department of Medicine, Division of Allergy and Infectious Diseases, Center for Emerging and Re-emerging Infectious Disease (CERID), University of Washington, Seattle, Washington, United States of America.<br /><searchLink fieldCode="AU" term="%22Hulverson+MA%22">Hulverson MA</searchLink>; Department of Medicine, Division of Allergy and Infectious Diseases, Center for Emerging and Re-emerging Infectious Disease (CERID), University of Washington, Seattle, Washington, United States of America.<br /><searchLink fieldCode="AU" term="%22Schaefer+DA%22">Schaefer DA</searchLink>; School of Animal and Comparative Biomedical Sciences, College of Agriculture and Life Sciences, University of Arizona, Tucson, Arizona, United States of America.<br /><searchLink fieldCode="AU" term="%22Betzer+DP%22">Betzer DP</searchLink>; School of Animal and Comparative Biomedical Sciences, College of Agriculture and Life Sciences, University of Arizona, Tucson, Arizona, United States of America.<br /><searchLink fieldCode="AU" term="%22Riggs+MW%22">Riggs MW</searchLink>; School of Animal and Comparative Biomedical Sciences, College of Agriculture and Life Sciences, University of Arizona, Tucson, Arizona, United States of America.<br /><searchLink fieldCode="AU" term="%22Huang+W%22">Huang W</searchLink>; Department of Biochemistry, University of Washington, Seattle, Washington United States of America.<br /><searchLink fieldCode="AU" term="%22Sun+V%22">Sun V</searchLink>; Department of Pharmaceutics, University of Washington, Seattle, Washington United States of America.<br /><searchLink fieldCode="AU" term="%22Whitman+GR%22">Whitman GR</searchLink>; Department of Medicine, Division of Allergy and Infectious Diseases, Center for Emerging and Re-emerging Infectious Disease (CERID), University of Washington, Seattle, Washington, United States of America.<br /><searchLink fieldCode="AU" term="%22McCloskey+MC%22">McCloskey MC</searchLink>; Department of Medicine, Division of Allergy and Infectious Diseases, Center for Emerging and Re-emerging Infectious Disease (CERID), University of Washington, Seattle, Washington, United States of America.<br /><searchLink fieldCode="AU" term="%22Marsh+K%22">Marsh K</searchLink>; Research and Development, AbbVie Inc, North Chicago, Illinois, United States of America.<br /><searchLink fieldCode="AU" term="%22Buck+WR%22">Buck WR</searchLink>; Research and Development, AbbVie Inc, North Chicago, Illinois, United States of America.<br /><searchLink fieldCode="AU" term="%22Wagner+DS%22">Wagner DS</searchLink>; Research and Development, AbbVie Inc, North Chicago, Illinois, United States of America.<br /><searchLink fieldCode="AU" term="%22Yang+J%22">Yang J</searchLink>; Research and Development, AbbVie Inc, North Chicago, Illinois, United States of America.<br /><searchLink fieldCode="AU" term="%22Bowman+AP%22">Bowman AP</searchLink>; Research and Development, AbbVie Inc, North Chicago, Illinois, United States of America.<br /><searchLink fieldCode="AU" term="%22Ciurlionis+R%22">Ciurlionis R</searchLink>; Research and Development, AbbVie Inc, North Chicago, Illinois, United States of America.<br /><searchLink fieldCode="AU" term="%22Ajiboye+J%22">Ajiboye J</searchLink>; Cellular, Molecular and Biomedical Sciences Graduate Program, University of Vermont, Burlington, Vermont United States of America.; Institute of Parasitology, Vetsuisse Faculty, University of Bern, Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Hemphill+A%22">Hemphill A</searchLink>; Institute of Parasitology, Vetsuisse Faculty, University of Bern, Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Sigalapalli+DK%22">Sigalapalli DK</searchLink>; Department of Biochemistry, University of Washington, Seattle, Washington United States of America.<br /><searchLink fieldCode="AU" term="%22Arnold+SLM%22">Arnold SLM</searchLink>; Department of Pharmaceutics, University of Washington, Seattle, Washington United States of America.<br /><searchLink fieldCode="AU" term="%22Barrett+LK%22">Barrett LK</searchLink>; Department of Medicine, Division of Allergy and Infectious Diseases, Center for Emerging and Re-emerging Infectious Disease (CERID), University of Washington, Seattle, Washington, United States of America.<br /><searchLink fieldCode="AU" term="%22Ojo+KK%22">Ojo KK</searchLink>; Department of Medicine, Division of Allergy and Infectious Diseases, Center for Emerging and Re-emerging Infectious Disease (CERID), University of Washington, Seattle, Washington, United States of America.<br /><searchLink fieldCode="AU" term="%22Fan+E%22">Fan E</searchLink>; Department of Biochemistry, University of Washington, Seattle, Washington United States of America.<br /><searchLink fieldCode="AU" term="%22Van+Voorhis+WC%22">Van Voorhis WC</searchLink>; Department of Medicine, Division of Allergy and Infectious Diseases, Center for Emerging and Re-emerging Infectious Disease (CERID), University of Washington, Seattle, Washington, United States of America.
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